EA200702579A1 - Способ получения розувастатина - Google Patents

Способ получения розувастатина

Info

Publication number
EA200702579A1
EA200702579A1 EA200702579A EA200702579A EA200702579A1 EA 200702579 A1 EA200702579 A1 EA 200702579A1 EA 200702579 A EA200702579 A EA 200702579A EA 200702579 A EA200702579 A EA 200702579A EA 200702579 A1 EA200702579 A1 EA 200702579A1
Authority
EA
Eurasian Patent Office
Prior art keywords
reaction
compound
organic
present
formula iii
Prior art date
Application number
EA200702579A
Other languages
English (en)
Other versions
EA013304B1 (ru
Inventor
Янош Фишер
Аттила Семзё
Кристина Вукич
Петер Эрдельи
Каталин Сёке
Андреа Донат
Original Assignee
Рихтер Гедеон Ведьесети Дьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Ведьесети Дьяр Рт. filed Critical Рихтер Гедеон Ведьесети Дьяр Рт.
Publication of EA200702579A1 publication Critical patent/EA200702579A1/ru
Publication of EA013304B1 publication Critical patent/EA013304B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Объектом настоящего изобретения является способ получения розувастатина посредством превращения соединения формулы IIпутем щелочного гидролиза с получением соединения формулы IIIс последующим взаимодействием с органическим или неорганическим основанием с образованием соли, отщепление ацетонидной группы, и взаимодействием с хлоридом кальция в основании. Дополнительным объектом настоящего изобретения является соединение формулы III и его соли, полученные взаимодействием с органическим или неорганическим основанием.
EA200702579A 2005-05-26 2006-05-26 Способ получения розувастатина EA013304B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0500537A HU227120B1 (hu) 2005-05-26 2005-05-26 Eljárás rosuvastatin kalciumsójának elõállítására új intermediereken keresztül
PCT/HU2006/000049 WO2006126035A2 (en) 2005-05-26 2006-05-26 Process for the preparation of rosuvastatin

Publications (2)

Publication Number Publication Date
EA200702579A1 true EA200702579A1 (ru) 2008-04-28
EA013304B1 EA013304B1 (ru) 2010-04-30

Family

ID=89986052

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702579A EA013304B1 (ru) 2005-05-26 2006-05-26 Способ получения розувастатина

Country Status (13)

Country Link
EP (1) EP1902036B1 (ru)
AT (1) ATE461924T1 (ru)
DE (1) DE602006013136D1 (ru)
DK (1) DK1902036T3 (ru)
EA (1) EA013304B1 (ru)
ES (1) ES2342788T3 (ru)
HR (1) HRP20100290T1 (ru)
HU (1) HU227120B1 (ru)
ME (1) ME01781B (ru)
PL (1) PL1902036T3 (ru)
RS (1) RS51205B (ru)
SI (1) SI1902036T1 (ru)
WO (1) WO2006126035A2 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539278A (ja) * 2006-09-18 2008-11-13 テバ ファーマシューティカル インダストリーズ リミティド 結晶性ロスバスタチンカルシウム
WO2009157014A2 (en) * 2008-01-30 2009-12-30 Cadila Healthcare Limited A process for preparing hmg-coa reductase inhibitors and intermediates
US20110245285A1 (en) * 2008-09-09 2011-10-06 Biocon Limited Process for preparation of rosuvastatin acetonide calcium
MX2011007478A (es) 2009-01-15 2011-09-15 Sag Egis Gyogyszergyar Nylvanosan Muekoedoe Reszvenytarsa Proceso para la preparacion de sales de rosuvastatina.
WO2011104725A2 (en) 2010-02-23 2011-09-01 Cadila Healthcare Limited Hmg-coa reductase inhibitors and process for the preparation thereof
WO2012038785A1 (en) * 2010-09-21 2012-03-29 Biocon Limited Polymorphs of rosuvastatin acetonide calcium ((3r,5s,6e)-7-[4-(4- fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimn)in-5- yl)vinyl)-2,2-dimethyl-l,3-dioxan-4-yl) acetic acid calcium salt
MX2010011006A (es) * 2010-10-06 2012-04-18 Senosiain S A De C V Lab Nueva sal de un derivado de pirimidina.
WO2012073256A1 (en) * 2010-11-29 2012-06-07 Cadila Healthcare Limited Salts of rosuvastatin
CN102358747B (zh) * 2011-08-30 2012-09-19 浙江宏元药业有限公司 瑞舒伐他汀钙中间体及制备瑞舒伐他汀钙中间体和瑞舒伐他汀钙的方法
CN102796036B (zh) * 2012-09-12 2014-06-04 江苏阿尔法药业有限公司 一种阿托伐他汀钙的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9903472D0 (en) * 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
GB0011163D0 (en) * 2000-05-10 2000-06-28 Astrazeneca Ab Chemical compound
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process

Also Published As

Publication number Publication date
WO2006126035A3 (en) 2007-06-14
PL1902036T3 (pl) 2010-08-31
WO2006126035A2 (en) 2006-11-30
DE602006013136D1 (de) 2010-05-06
ME01781B (me) 2010-12-31
EP1902036B1 (en) 2010-03-24
HRP20100290T1 (hr) 2010-06-30
SI1902036T1 (sl) 2010-05-31
EA013304B1 (ru) 2010-04-30
HUP0500537A2 (en) 2007-05-02
EP1902036A2 (en) 2008-03-26
HU0500537D0 (en) 2005-08-29
HUP0500537A3 (en) 2008-04-28
RS51205B (sr) 2010-12-31
DK1902036T3 (da) 2010-06-28
HU227120B1 (hu) 2010-07-28
ATE461924T1 (de) 2010-04-15
ES2342788T3 (es) 2010-07-14

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