EA200702558A1 - Способ получения производных сульфамида - Google Patents
Способ получения производных сульфамидаInfo
- Publication number
- EA200702558A1 EA200702558A1 EA200702558A EA200702558A EA200702558A1 EA 200702558 A1 EA200702558 A1 EA 200702558A1 EA 200702558 A EA200702558 A EA 200702558A EA 200702558 A EA200702558 A EA 200702558A EA 200702558 A1 EA200702558 A1 EA 200702558A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sulfamide
- derivatives
- sulfonylimine
- producing derivatives
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Настоящее изобретение направлено на способ получения производных сульфонилимина, в частности, производных формулы (XII), и производных сульфамида, в частности производных формулы (I). Способ включает в себя взаимодействие альдегида с замещенным или незамещенным сульфамидом в присутствии кислоты или TMSCI с получением соответствующего сульфонилимина и необязательным восстановлением или гидрированием сульфонилимина с получением соответствующего производного сульфамида.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68315105P | 2005-05-20 | 2005-05-20 | |
PCT/US2006/014766 WO2006127184A1 (en) | 2005-05-20 | 2006-04-19 | Process for preparation of sulfamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200702558A1 true EA200702558A1 (ru) | 2008-06-30 |
Family
ID=36716875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200702558A EA200702558A1 (ru) | 2005-05-20 | 2006-04-19 | Способ получения производных сульфамида |
Country Status (16)
Country | Link |
---|---|
US (1) | US8283478B2 (ru) |
EP (1) | EP1881959A1 (ru) |
JP (1) | JP2008545650A (ru) |
KR (1) | KR20080012360A (ru) |
CN (1) | CN101754947A (ru) |
AR (1) | AR057305A1 (ru) |
AU (1) | AU2006249577A1 (ru) |
BR (1) | BRPI0610864A2 (ru) |
CA (1) | CA2609185A1 (ru) |
EA (1) | EA200702558A1 (ru) |
IL (1) | IL187458A0 (ru) |
MX (1) | MX2007014613A (ru) |
NO (1) | NO20076462L (ru) |
PE (1) | PE20061450A1 (ru) |
TW (1) | TW200716525A (ru) |
WO (1) | WO2006127184A1 (ru) |
Families Citing this family (23)
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TW200612905A (en) * | 2004-06-16 | 2006-05-01 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
MY142329A (en) * | 2004-08-24 | 2010-11-15 | Janssen Pharmaceutica Nv | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents. |
KR20080012360A (ko) | 2005-05-20 | 2008-02-11 | 얀센 파마슈티카 엔.브이. | 설파미드 유도체의 제조 방법 |
US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8716231B2 (en) * | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
US8492431B2 (en) * | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
US20070191449A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression |
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TW200812573A (en) | 2006-05-19 | 2008-03-16 | Janssen Pharmaceutica Nv | Co-therapy for the treatment of epilepsy and related disorders |
CN100548979C (zh) * | 2007-01-12 | 2009-10-14 | 中国科学院上海有机化学研究所 | 一种合成3-甲氨基吲哚化合物的方法 |
US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
US8809385B2 (en) | 2008-06-23 | 2014-08-19 | Janssen Pharmaceutica Nv | Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide |
US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
CN102976953A (zh) * | 2011-09-05 | 2013-03-20 | 上海药明康德新药开发有限公司 | 手性α-二氟甲基苯基乙胺的制备方法 |
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-
2006
- 2006-04-19 KR KR1020077029126A patent/KR20080012360A/ko not_active Application Discontinuation
- 2006-04-19 CN CN200680026669A patent/CN101754947A/zh active Pending
- 2006-04-19 WO PCT/US2006/014766 patent/WO2006127184A1/en active Application Filing
- 2006-04-19 BR BRPI0610864-4A patent/BRPI0610864A2/pt not_active Application Discontinuation
- 2006-04-19 JP JP2008512290A patent/JP2008545650A/ja not_active Withdrawn
- 2006-04-19 EA EA200702558A patent/EA200702558A1/ru unknown
- 2006-04-19 MX MX2007014613A patent/MX2007014613A/es not_active Application Discontinuation
- 2006-04-19 EP EP06750739A patent/EP1881959A1/en not_active Withdrawn
- 2006-04-19 US US11/406,794 patent/US8283478B2/en not_active Expired - Fee Related
- 2006-04-19 AU AU2006249577A patent/AU2006249577A1/en not_active Abandoned
- 2006-04-19 CA CA002609185A patent/CA2609185A1/en not_active Abandoned
- 2006-05-19 AR ARP060102055A patent/AR057305A1/es not_active Application Discontinuation
- 2006-05-19 PE PE2006000529A patent/PE20061450A1/es not_active Application Discontinuation
- 2006-05-19 TW TW095117749A patent/TW200716525A/zh unknown
-
2007
- 2007-11-18 IL IL187458A patent/IL187458A0/en unknown
- 2007-12-14 NO NO20076462A patent/NO20076462L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2007014613A (es) | 2008-04-02 |
CN101754947A (zh) | 2010-06-23 |
AU2006249577A1 (en) | 2006-11-30 |
TW200716525A (en) | 2007-05-01 |
WO2006127184A1 (en) | 2006-11-30 |
AR057305A1 (es) | 2007-11-28 |
EP1881959A1 (en) | 2008-01-30 |
CA2609185A1 (en) | 2006-11-30 |
JP2008545650A (ja) | 2008-12-18 |
PE20061450A1 (es) | 2007-01-16 |
KR20080012360A (ko) | 2008-02-11 |
IL187458A0 (en) | 2008-03-20 |
US20060270856A1 (en) | 2006-11-30 |
US8283478B2 (en) | 2012-10-09 |
NO20076462L (no) | 2008-02-08 |
BRPI0610864A2 (pt) | 2010-08-03 |
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