DE602005023732D1 - Pyrrolotriazinverbindungen - Google Patents

Pyrrolotriazinverbindungen

Info

Publication number
DE602005023732D1
DE602005023732D1 DE602005023732T DE602005023732T DE602005023732D1 DE 602005023732 D1 DE602005023732 D1 DE 602005023732D1 DE 602005023732 T DE602005023732 T DE 602005023732T DE 602005023732 T DE602005023732 T DE 602005023732T DE 602005023732 D1 DE602005023732 D1 DE 602005023732D1
Authority
DE
Germany
Prior art keywords
compounds
useful
growth factor
factor receptors
her1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005023732T
Other languages
English (en)
Inventor
Ashvinikumar V Gavai
Harold Mastalerz
Jean-Paul Daris
Pierre Dextraze
Philippe Lapointe
Edward H Ruediger
Dolatrai M Vyas
Guifen Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE602005023732D1 publication Critical patent/DE602005023732D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DE602005023732T 2004-07-01 2005-06-22 Pyrrolotriazinverbindungen Active DE602005023732D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58476804P 2004-07-01 2004-07-01
PCT/US2005/022059 WO2006007468A1 (en) 2004-07-01 2005-06-22 Pyrrolotriazine compounds

Publications (1)

Publication Number Publication Date
DE602005023732D1 true DE602005023732D1 (de) 2010-11-04

Family

ID=35784205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005023732T Active DE602005023732D1 (de) 2004-07-01 2005-06-22 Pyrrolotriazinverbindungen

Country Status (6)

Country Link
US (1) US7102003B2 (de)
EP (1) EP1773791B1 (de)
AT (1) ATE482212T1 (de)
DE (1) DE602005023732D1 (de)
ES (1) ES2350697T3 (de)
WO (1) WO2006007468A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7504521B2 (en) * 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
PE20060421A1 (es) 2004-08-12 2006-06-01 Bristol Myers Squibb Co Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
US7894174B2 (en) * 2004-08-23 2011-02-22 Monolithic Power Systems, Inc. Method and apparatus for fault detection scheme for cold cathode fluorescent lamp (CCFL) integrated circuits
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
TW200635927A (en) * 2004-12-22 2006-10-16 Bristol Myers Squibb Co Synthetic process
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
CN101453818B (zh) 2007-11-29 2014-03-19 杭州茂力半导体技术有限公司 放电灯的电路保护和调节装置
US9732320B2 (en) 2008-01-18 2017-08-15 The Brigham And Women's Hospital, Inc. Selective differentiation, identification, and modulation of human TH17 cells
US20110086850A1 (en) * 2008-04-11 2011-04-14 Board Of Regents, The University Of Texas System Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
EP2376491B1 (de) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazine als alk- und jak2-inhibitoren
WO2024044570A1 (en) * 2022-08-22 2024-02-29 Iambic Therapeutics, Inc. Compounds and methods for modulating her2

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163399A1 (en) 1994-11-24 1996-05-25 Katsuhiro Kawano Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor
EP0923582B1 (de) 1996-08-28 2006-09-20 Pfizer Inc. Substituierte 6,5-heterobicyclische-derivate
NZ516292A (en) 1999-05-21 2004-01-30 Bristol Myers Squibb Co Pyrrolotriazine inhibitors of kinases
AU6473600A (en) * 1999-08-23 2001-03-19 Shionogi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
CA2429628A1 (en) 2000-11-17 2002-05-23 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
RS92004A (en) 2002-04-23 2006-12-15 Bristol-Myers Squibb Company Pyrrolo-triazine aniline compounds useful as kinase inhibitors
PL373371A1 (en) * 2002-04-23 2005-08-22 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200407143A (en) * 2002-05-21 2004-05-16 Bristol Myers Squibb Co Pyrrolotriazinone compounds and their use to treat diseases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
TWI272271B (en) * 2002-07-19 2007-02-01 Bristol Myers Squibb Co Process for preparing certain pyrrolotriazine compounds
US6951859B2 (en) * 2002-08-02 2005-10-04 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines

Also Published As

Publication number Publication date
US20060014745A1 (en) 2006-01-19
US7102003B2 (en) 2006-09-05
WO2006007468A1 (en) 2006-01-19
EP1773791B1 (de) 2010-09-22
ATE482212T1 (de) 2010-10-15
EP1773791A1 (de) 2007-04-18
EP1773791A4 (de) 2009-08-26
ES2350697T3 (es) 2011-01-26

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