DK1569937T3 - C-6 modificerede indazolylpyrrolotriaziner - Google Patents

C-6 modificerede indazolylpyrrolotriaziner

Info

Publication number
DK1569937T3
DK1569937T3 DK03813396.3T DK03813396T DK1569937T3 DK 1569937 T3 DK1569937 T3 DK 1569937T3 DK 03813396 T DK03813396 T DK 03813396T DK 1569937 T3 DK1569937 T3 DK 1569937T3
Authority
DK
Denmark
Prior art keywords
indazolylpyrrolotriazines
modified
modified indazolylpyrrolotriazines
Prior art date
Application number
DK03813396.3T
Other languages
English (en)
Inventor
Gregory D Vite
Ashvinikumar V Gavai
Brian E Fink
Harold Mastalerz
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1569937T3 publication Critical patent/DK1569937T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK03813396.3T 2002-12-13 2003-12-12 C-6 modificerede indazolylpyrrolotriaziner DK1569937T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13
PCT/US2003/039542 WO2004054514A2 (en) 2002-12-13 2003-12-12 C-6 modified indazolylpyrrolotriazines

Publications (1)

Publication Number Publication Date
DK1569937T3 true DK1569937T3 (da) 2012-01-02

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03813396.3T DK1569937T3 (da) 2002-12-13 2003-12-12 C-6 modificerede indazolylpyrrolotriaziner

Country Status (27)

Country Link
US (2) US6916815B2 (da)
EP (1) EP1569937B1 (da)
JP (1) JP4511367B2 (da)
KR (1) KR101073801B1 (da)
CN (2) CN1726216A (da)
AR (1) AR042450A1 (da)
AT (1) ATE534648T1 (da)
AU (1) AU2003300877B2 (da)
BR (1) BR0316755A (da)
CA (1) CA2509650C (da)
CO (1) CO5570660A2 (da)
DK (1) DK1569937T3 (da)
ES (1) ES2374393T3 (da)
HR (1) HRP20050535A2 (da)
IS (1) IS7890A (da)
MX (1) MXPA05006164A (da)
NO (1) NO20052733L (da)
NZ (1) NZ540338A (da)
PE (1) PE20040805A1 (da)
PL (1) PL377517A1 (da)
PT (1) PT1569937E (da)
RS (1) RS20050441A (da)
RU (1) RU2356903C2 (da)
TW (1) TW200420565A (da)
UA (1) UA80591C2 (da)
WO (1) WO2004054514A2 (da)
ZA (1) ZA200504507B (da)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
CN101395158A (zh) 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
WO2008074863A1 (en) * 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
US20090083483A1 (en) * 2007-09-24 2009-03-26 International Business Machines Corporation Power Conservation In A RAID Array
US8166326B2 (en) * 2007-11-08 2012-04-24 International Business Machines Corporation Managing power consumption in a computer
US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
US8041521B2 (en) * 2007-11-28 2011-10-18 International Business Machines Corporation Estimating power consumption of computing components configured in a computing system
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US20110086850A1 (en) * 2008-04-11 2011-04-14 Board Of Regents, The University Of Texas System Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
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US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
US9458164B2 (en) * 2013-03-11 2016-10-04 Bristol-Myers Squibb Company Pyrrolopyridazines as potassium ion channel inhibitors
CN105026399B (zh) * 2013-03-11 2017-06-23 百时美施贵宝公司 作为钾离子通道抑制剂的吡咯并三嗪类化合物
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
CN111533708B (zh) * 2020-06-12 2021-03-16 上海馨远医药科技有限公司 一种手性n-叔丁氧羰基吗啉-3-羧酸的制备方法

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Also Published As

Publication number Publication date
CN101723948A (zh) 2010-06-09
JP4511367B2 (ja) 2010-07-28
BR0316755A (pt) 2005-10-25
TW200420565A (en) 2004-10-16
PE20040805A1 (es) 2004-11-20
CA2509650C (en) 2007-10-30
EP1569937A4 (en) 2007-08-08
AU2003300877A1 (en) 2004-07-09
US6916815B2 (en) 2005-07-12
CA2509650A1 (en) 2004-07-01
JP2006509826A (ja) 2006-03-23
AU2003300877B2 (en) 2010-02-18
NZ540338A (en) 2008-05-30
IS7890A (is) 2005-06-10
KR20050084242A (ko) 2005-08-26
EP1569937B1 (en) 2011-11-23
ZA200504507B (en) 2006-08-30
EP1569937A2 (en) 2005-09-07
RU2005120650A (ru) 2006-01-20
UA80591C2 (en) 2007-10-10
US20040142931A1 (en) 2004-07-22
US7148220B2 (en) 2006-12-12
PL377517A1 (pl) 2006-02-06
NO20052733D0 (no) 2005-06-07
ES2374393T3 (es) 2012-02-16
RS20050441A (en) 2007-04-10
CO5570660A2 (es) 2005-10-31
CN1726216A (zh) 2006-01-25
MXPA05006164A (es) 2005-08-26
NO20052733L (no) 2005-07-07
AR042450A1 (es) 2005-06-22
WO2004054514A3 (en) 2004-10-07
ATE534648T1 (de) 2011-12-15
WO2004054514A2 (en) 2004-07-01
KR101073801B1 (ko) 2011-10-13
PT1569937E (pt) 2012-01-04
US20050222153A1 (en) 2005-10-06
RU2356903C2 (ru) 2009-05-27
HRP20050535A2 (en) 2005-12-31

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