ATE534648T1 - C-6-modifizierte indazolylpyrrolotriazine - Google Patents

C-6-modifizierte indazolylpyrrolotriazine

Info

Publication number
ATE534648T1
ATE534648T1 AT03813396T AT03813396T ATE534648T1 AT E534648 T1 ATE534648 T1 AT E534648T1 AT 03813396 T AT03813396 T AT 03813396T AT 03813396 T AT03813396 T AT 03813396T AT E534648 T1 ATE534648 T1 AT E534648T1
Authority
AT
Austria
Prior art keywords
indazolylpyrrolotriazines
modified
modified indazolylpyrrolotriazines
Prior art date
Application number
AT03813396T
Other languages
English (en)
Inventor
Gregory Vite
Ashvinikumar Gavai
Brian Fink
Harold Mastalerz
John Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE534648T1 publication Critical patent/ATE534648T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT03813396T 2002-12-13 2003-12-12 C-6-modifizierte indazolylpyrrolotriazine ATE534648T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13
PCT/US2003/039542 WO2004054514A2 (en) 2002-12-13 2003-12-12 C-6 modified indazolylpyrrolotriazines

Publications (1)

Publication Number Publication Date
ATE534648T1 true ATE534648T1 (de) 2011-12-15

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03813396T ATE534648T1 (de) 2002-12-13 2003-12-12 C-6-modifizierte indazolylpyrrolotriazine

Country Status (27)

Country Link
US (2) US6916815B2 (de)
EP (1) EP1569937B1 (de)
JP (1) JP4511367B2 (de)
KR (1) KR101073801B1 (de)
CN (2) CN101723948A (de)
AR (1) AR042450A1 (de)
AT (1) ATE534648T1 (de)
AU (1) AU2003300877B2 (de)
BR (1) BR0316755A (de)
CA (1) CA2509650C (de)
CO (1) CO5570660A2 (de)
DK (1) DK1569937T3 (de)
ES (1) ES2374393T3 (de)
HR (1) HRP20050535A2 (de)
IS (1) IS7890A (de)
MX (1) MXPA05006164A (de)
NO (1) NO20052733L (de)
NZ (1) NZ540338A (de)
PE (1) PE20040805A1 (de)
PL (1) PL377517A1 (de)
PT (1) PT1569937E (de)
RS (1) RS20050441A (de)
RU (1) RU2356903C2 (de)
TW (1) TW200420565A (de)
UA (1) UA80591C2 (de)
WO (1) WO2004054514A2 (de)
ZA (1) ZA200504507B (de)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
AU2004212435A1 (en) 2003-02-05 2004-08-26 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine kinase inhibitors
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US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
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US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
CN101180315A (zh) 2005-04-18 2008-05-14 诺和诺德公司 Il-21变体
US7405213B2 (en) * 2005-07-01 2008-07-29 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
AU2007223342A1 (en) 2006-03-07 2007-09-13 Bristol-Myers Squibb Company Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
JP2010512769A (ja) * 2006-12-21 2010-04-30 ノヴォ ノルディスク アクティーゼルスカブ Ｉｌ−２１受容体との結合が変化したインターロイキン−２１変異体
US20090083483A1 (en) * 2007-09-24 2009-03-26 International Business Machines Corporation Power Conservation In A RAID Array
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US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
US8041521B2 (en) * 2007-11-28 2011-10-18 International Business Machines Corporation Estimating power consumption of computing components configured in a computing system
CA2719362A1 (en) * 2008-04-04 2009-10-08 Gilead Sciences, Inc. Pyrrolotriazinone derivatives for use as stearoyl coa desaturase inhibitors
EP2268637A1 (de) 2008-04-04 2011-01-05 Gilead Sciences, Inc. Triazolpyridinonderivate zur verwendung als stearoyl-coa-desaturase-hemmer
US20110086850A1 (en) * 2008-04-11 2011-04-14 Board Of Regents, The University Of Texas System Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
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US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
EP2970294B1 (de) * 2013-03-11 2016-12-28 Bristol-Myers Squibb Company Pyrrolotriazine als kaliumionenkanalhemmer
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
JP6386527B2 (ja) * 2013-03-11 2018-09-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カリウムイオンチャネル阻害剤としてのピロロピリダジン
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
CN111533708B (zh) * 2020-06-12 2021-03-16 上海馨远医药科技有限公司 一种手性n-叔丁氧羰基吗啉-3-羧酸的制备方法

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Also Published As

Publication number Publication date
EP1569937A4 (de) 2007-08-08
WO2004054514A3 (en) 2004-10-07
US6916815B2 (en) 2005-07-12
US20040142931A1 (en) 2004-07-22
HRP20050535A2 (en) 2005-12-31
BR0316755A (pt) 2005-10-25
UA80591C2 (en) 2007-10-10
AR042450A1 (es) 2005-06-22
US20050222153A1 (en) 2005-10-06
KR20050084242A (ko) 2005-08-26
RS20050441A (en) 2007-04-10
TW200420565A (en) 2004-10-16
PT1569937E (pt) 2012-01-04
RU2005120650A (ru) 2006-01-20
PL377517A1 (pl) 2006-02-06
CA2509650A1 (en) 2004-07-01
RU2356903C2 (ru) 2009-05-27
MXPA05006164A (es) 2005-08-26
JP4511367B2 (ja) 2010-07-28
CN101723948A (zh) 2010-06-09
US7148220B2 (en) 2006-12-12
AU2003300877A1 (en) 2004-07-09
ZA200504507B (en) 2006-08-30
PE20040805A1 (es) 2004-11-20
NO20052733D0 (no) 2005-06-07
ES2374393T3 (es) 2012-02-16
IS7890A (is) 2005-06-10
CA2509650C (en) 2007-10-30
DK1569937T3 (da) 2012-01-02
EP1569937A2 (de) 2005-09-07
NO20052733L (no) 2005-07-07
CO5570660A2 (es) 2005-10-31
KR101073801B1 (ko) 2011-10-13
AU2003300877B2 (en) 2010-02-18
NZ540338A (en) 2008-05-30
JP2006509826A (ja) 2006-03-23
WO2004054514A2 (en) 2004-07-01
EP1569937B1 (de) 2011-11-23
CN1726216A (zh) 2006-01-25

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