BR0011778A - Tienopirimidinas - Google Patents

Tienopirimidinas

Info

Publication number
BR0011778A
BR0011778A BR0011778-1A BR0011778A BR0011778A BR 0011778 A BR0011778 A BR 0011778A BR 0011778 A BR0011778 A BR 0011778A BR 0011778 A BR0011778 A BR 0011778A
Authority
BR
Brazil
Prior art keywords
thienopyrimidines
treatment
disorders
thyenopyrimidines
inhibition
Prior art date
Application number
BR0011778-1A
Other languages
English (en)
Inventor
Rochus Jonas
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0011778A publication Critical patent/BR0011778A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"TIENOPIRIMIDINAS". Tienopirimidinas da fórmula I e seus sais fisiologicamente aceitáveis, nos quais R^ 1^, R^ 2^ e X têm os significados indicados na Reivindicação 1, exibem inibição de fosfodiesterase V e podem ser empregados para o tratamento de distúrbios do sistema cardiovascular e para o tratamento e/ou terapia de distúrbios de potência.
BR0011778-1A 1999-06-19 2000-06-07 Tienopirimidinas BR0011778A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19928146A DE19928146A1 (de) 1999-06-19 1999-06-19 Thienopyrimidine
PCT/EP2000/005278 WO2000078767A1 (de) 1999-06-19 2000-06-07 Thienopyrimidine als phosphodiesterase hemmer

Publications (1)

Publication Number Publication Date
BR0011778A true BR0011778A (pt) 2002-04-23

Family

ID=7911858

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011778-1A BR0011778A (pt) 1999-06-19 2000-06-07 Tienopirimidinas

Country Status (24)

Country Link
US (1) US6787548B1 (pt)
EP (1) EP1189907B1 (pt)
JP (1) JP2003502429A (pt)
KR (1) KR20020010719A (pt)
CN (1) CN1144806C (pt)
AR (1) AR024380A1 (pt)
AT (1) ATE285412T1 (pt)
AU (1) AU767273B2 (pt)
BR (1) BR0011778A (pt)
CA (1) CA2375278A1 (pt)
CZ (1) CZ293901B6 (pt)
DE (2) DE19928146A1 (pt)
ES (1) ES2234613T3 (pt)
HK (1) HK1047434B (pt)
HU (1) HUP0201730A3 (pt)
MX (1) MXPA01013228A (pt)
NO (1) NO20016201L (pt)
PL (1) PL351822A1 (pt)
PT (1) PT1189907E (pt)
RU (1) RU2238274C2 (pt)
SK (1) SK18222001A3 (pt)
UA (1) UA72256C2 (pt)
WO (1) WO2000078767A1 (pt)
ZA (1) ZA200200440B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
DE10001021A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische Zubereitung
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
DE10017947A1 (de) 2000-04-11 2001-10-25 Merck Patent Gmbh Verfahren zur Herstellung benzo-annelierter Heterocyclen
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10107261B4 (de) * 2001-02-16 2005-03-10 Merck Patent Gmbh Pharmazeutische Zusammensetzung
WO2003035653A1 (fr) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Compose pyridothienopyrimidine et son sel
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19819023A1 (de) 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
HUP0201730A3 (en) 2004-12-28
CN1144806C (zh) 2004-04-07
AU5220400A (en) 2001-01-09
EP1189907B1 (de) 2004-12-22
PL351822A1 (en) 2003-06-16
CA2375278A1 (en) 2000-12-28
US6787548B1 (en) 2004-09-07
KR20020010719A (ko) 2002-02-04
CZ293901B6 (cs) 2004-08-18
UA72256C2 (uk) 2005-02-15
EP1189907A1 (de) 2002-03-27
ATE285412T1 (de) 2005-01-15
DE50009042D1 (en) 2005-01-27
RU2238274C2 (ru) 2004-10-20
DE19928146A1 (de) 2000-12-21
JP2003502429A (ja) 2003-01-21
NO20016201D0 (no) 2001-12-18
CN1355805A (zh) 2002-06-26
ZA200200440B (en) 2003-06-25
HK1047434A1 (en) 2003-02-21
SK18222001A3 (sk) 2002-06-04
AR024380A1 (es) 2002-10-02
MXPA01013228A (es) 2002-07-02
CZ20014422A3 (cs) 2002-03-13
AU767273B2 (en) 2003-11-06
HK1047434B (zh) 2005-01-28
NO20016201L (no) 2001-12-18
WO2000078767A1 (de) 2000-12-28
PT1189907E (pt) 2005-05-31
ES2234613T3 (es) 2005-07-01
HUP0201730A2 (en) 2002-09-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.