US7863444B2
(en)
|
1997-03-19 |
2011-01-04 |
Abbott Laboratories |
4-aminopyrrolopyrimidines as kinase inhibitors
|
WO2000012089A1
(en)
*
|
1998-08-31 |
2000-03-09 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
ID29028A
(id)
*
|
1998-09-18 |
2001-07-26 |
Basf Ag |
Pirolopirimidina sebagai penghambat protein kinase
|
US6713474B2
(en)
|
1998-09-18 |
2004-03-30 |
Abbott Gmbh & Co. Kg |
Pyrrolopyrimidines as therapeutic agents
|
US6265403B1
(en)
*
|
1999-01-20 |
2001-07-24 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
US6432979B1
(en)
|
1999-08-12 |
2002-08-13 |
American Cyanamid Company |
Method of treating or inhibiting colonic polyps and colorectal cancer
|
KR20020063854A
(ko)
*
|
1999-09-17 |
2002-08-05 |
애보트 게엠베하 운트 콤파니 카게 |
치료제로서의 키나제 억제제
|
MXPA02002898A
(es)
|
1999-09-17 |
2003-10-14 |
Abbott Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
US7071199B1
(en)
|
1999-09-17 |
2006-07-04 |
Abbott Gmbh & Cco. Kg |
Kinase inhibitors as therapeutic agents
|
US7101869B2
(en)
|
1999-11-30 |
2006-09-05 |
Pfizer Inc. |
2,4-diaminopyrimidine compounds useful as immunosuppressants
|
US7369946B2
(en)
|
2000-03-29 |
2008-05-06 |
Abbott Gmbh & Co. Kg |
Method of identifying inhibitors of Tie-2
|
CA2404532A1
(en)
*
|
2000-03-29 |
2001-10-04 |
Nancy J. Bump |
Method of identifying inhibitors of tie-2
|
WO2001072751A1
(en)
*
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
US7091353B2
(en)
|
2000-12-27 |
2006-08-15 |
Celgene Corporation |
Isoindole-imide compounds, compositions, and uses thereof
|
KR100403860B1
(ko)
*
|
2000-12-27 |
2003-11-01 |
엘지전자 주식회사 |
차세대 이동통신 시스템의 접속시도시의 충돌감소를 위한알에이씨에이치 선택방법
|
TWI238824B
(en)
*
|
2001-05-14 |
2005-09-01 |
Novartis Ag |
4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
|
AP2003002929A0
(en)
*
|
2001-06-23 |
2003-12-31 |
Aventis Pharma Inc |
Pyrrolopyrimidines as protein kinase inhibitors
|
US20040266771A1
(en)
*
|
2001-06-29 |
2004-12-30 |
Alain Moussy |
Use of tyrosine kinase inhibitors for treating bone loss
|
WO2003002106A2
(en)
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitions for treating allergic diseases
|
US7678805B2
(en)
|
2001-06-29 |
2010-03-16 |
Ab Science |
Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
|
US20040259892A1
(en)
*
|
2001-06-29 |
2004-12-23 |
Alain Moussy |
Use of tyrosine kinase inhibitors for treating multiple sclerosis (ms)
|
WO2003003006A2
(en)
|
2001-06-29 |
2003-01-09 |
Ab Science |
New potent, selective and non toxic c-kit inhibitors
|
US7741335B2
(en)
|
2001-06-29 |
2010-06-22 |
Ab Science |
Use of tyrosine kinase inhibitors for treating inflammatory diseases
|
DE60227709D1
(de)
*
|
2001-06-29 |
2008-08-28 |
Ab Science |
Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
|
GB0121033D0
(en)
*
|
2001-08-30 |
2001-10-24 |
Novartis Ag |
Organic compounds
|
AU2002333524A1
(en)
*
|
2001-09-11 |
2003-03-24 |
Glaxosmithkline K.K. |
Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
|
US20030225273A1
(en)
*
|
2002-03-21 |
2003-12-04 |
Michaelides Michael R. |
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
|
US20030199525A1
(en)
*
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
DE60304718T2
(de)
|
2002-08-06 |
2007-04-26 |
Astrazeneca Ab |
Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
|
UA80171C2
(en)
*
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
WO2004100868A2
(en)
*
|
2003-04-23 |
2004-11-25 |
Abbott Laboratories |
Method of treating transplant rejection
|
EP1620094A4
(de)
*
|
2003-05-06 |
2010-04-28 |
Glaxosmithkline Llc |
Neue chemische verbindungen
|
US7429596B2
(en)
*
|
2003-06-20 |
2008-09-30 |
The Regents Of The University Of California |
1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
|
AR045037A1
(es)
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
|
BRPI0416656A
(pt)
*
|
2003-11-17 |
2007-01-16 |
Pfizer Prod Inc |
compostos de pirrolopirimidina úteis no tratamento do cáncer
|
EP1730148A4
(de)
*
|
2004-02-03 |
2009-08-19 |
Abbott Lab |
Aminobenzoxazole als therapeutische mittel
|
GB0403606D0
(en)
*
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
CA2566160C
(en)
*
|
2004-05-27 |
2011-01-18 |
Pfizer Products Inc. |
Pyrrolopyrimidine derivatives useful in cancer treatment
|
JP2008520744A
(ja)
|
2004-11-19 |
2008-06-19 |
ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア |
抗炎症性ピラゾロピリミジン
|
CA2601766A1
(en)
*
|
2005-03-17 |
2006-09-28 |
Novartis Ag |
N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
|
CN101801971A
(zh)
*
|
2005-09-30 |
2010-08-11 |
沃泰克斯药物股份有限公司 |
可用作janus激酶抑制剂的脱氮嘌呤
|
PT2385053E
(pt)
|
2005-11-17 |
2013-12-17 |
Osi Pharm Inc |
Intermediários para a preparação de compostos bicíclicos condensados como inibidores mtor
|
CN101336244B
(zh)
*
|
2005-12-08 |
2011-11-30 |
雅培制药有限公司 |
用作蛋白激酶抑制剂的9元杂二环化合物
|
EP1983971A4
(de)
*
|
2006-01-25 |
2010-11-24 |
Synta Pharmaceuticals Corp |
Substituierte aromatische verbindungen für entzündungs- und immunbedingte verwendung
|
US7659274B2
(en)
*
|
2006-01-25 |
2010-02-09 |
Osi Pharmaceuticals, Inc. |
Unsaturated mTOR inhibitors
|
CA2909277A1
(en)
|
2006-04-04 |
2007-10-11 |
Kevan M. Shokat |
Kinase antagonists
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
NZ601278A
(en)
|
2006-09-22 |
2013-09-27 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
EP1969934A1
(de)
*
|
2007-03-12 |
2008-09-17 |
Bayer CropScience AG |
4-Cycloalkyl-oder 4-arylsubstituierte Phenoxyphenylamidine und deren Verwendung als Fungizide
|
SG10202107066WA
(en)
*
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
US20120101113A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
US20110160232A1
(en)
|
2007-10-04 |
2011-06-30 |
Pingda Ren |
Certain chemical entities and therapeutic uses thereof
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
CN101965336B
(zh)
|
2008-01-04 |
2015-06-17 |
英特利凯恩有限责任公司 |
某些化学实体、组合物和方法
|
US8993580B2
(en)
|
2008-03-14 |
2015-03-31 |
Intellikine Llc |
Benzothiazole kinase inhibitors and methods of use
|
WO2009114870A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
AU2009225614A1
(en)
*
|
2008-03-19 |
2009-09-24 |
Osi Pharmaceuticals, Inc |
mTOR inhibitor salt forms
|
US9096611B2
(en)
|
2008-07-08 |
2015-08-04 |
Intellikine Llc |
Kinase inhibitors and methods of use
|
US20110224223A1
(en)
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
US8703778B2
(en)
|
2008-09-26 |
2014-04-22 |
Intellikine Llc |
Heterocyclic kinase inhibitors
|
JP5819195B2
(ja)
*
|
2008-10-16 |
2015-11-18 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
融合環ヘテロアリールキナーゼ阻害剤
|
US8476282B2
(en)
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
WO2010129816A2
(en)
|
2009-05-07 |
2010-11-11 |
Intellikine, Inc. |
Heterocyclic compounds and uses thereof
|
US7718662B1
(en)
*
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
US8980899B2
(en)
|
2009-10-16 |
2015-03-17 |
The Regents Of The University Of California |
Methods of inhibiting Ire1
|
CA2799579A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
AU2011261185A1
(en)
|
2010-06-03 |
2013-01-10 |
Pharmacyclics, Inc. |
The use of inhibitors of Bruton's tyrosine kinase (Btk)
|
JP2013545749A
(ja)
|
2010-11-10 |
2013-12-26 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
複素環化合物及びその使用
|
TWI674262B
(zh)
|
2011-01-10 |
2019-10-11 |
美商英菲尼提製藥股份有限公司 |
製備異喹啉酮之方法及異喹啉酮之固體形式
|
FR2970967B1
(fr)
*
|
2011-01-27 |
2013-02-15 |
Pf Medicament |
Derives de type azaindazole ou diazaindazole comme medicament
|
TWI592411B
(zh)
|
2011-02-23 |
2017-07-21 |
英特爾立秦有限責任公司 |
激酶抑制劑之組合及其用途
|
EP2694509B1
(de)
*
|
2011-04-05 |
2016-05-18 |
Pfizer Limited |
Pyrrolo[2,3-d]pyrimidinderivate als inhibitoren von tropomyosin-verwandten kinasen
|
WO2013010136A2
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
AU2012284088B2
(en)
|
2011-07-19 |
2015-10-08 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
EP2734530A1
(de)
|
2011-07-19 |
2014-05-28 |
Infinity Pharmaceuticals, Inc. |
Heterocyclische verbindungen und ihre verwendung
|
US8785470B2
(en)
|
2011-08-29 |
2014-07-22 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
WO2013077921A2
(en)
|
2011-09-02 |
2013-05-30 |
The Regents Of The University Of California |
Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CA2871926A1
(en)
|
2012-05-03 |
2013-11-07 |
Saint Louis College Of Pharmacy |
Compositions and methods for increasing neurotrophic peptides
|
US9540382B2
(en)
|
2012-06-04 |
2017-01-10 |
Pharmacyclics Llc |
Crystalline forms of a Bruton's tyrosine kinase inhibitor
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
KR20150032340A
(ko)
|
2012-07-24 |
2015-03-25 |
파마시클릭스, 인코포레이티드 |
브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
|
EP2689778A1
(de)
*
|
2012-07-27 |
2014-01-29 |
Pierre Fabre Medicament |
Azaindazol- oder Diazaindazol-Derivate zur Behandlung von Schmerzen
|
SG11201502331RA
(en)
|
2012-09-26 |
2015-04-29 |
Univ California |
Modulation of ire1
|
MA38183A1
(fr)
|
2012-11-15 |
2017-03-31 |
Pharmacyclics Inc |
Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
CN103333096A
(zh)
*
|
2013-06-25 |
2013-10-02 |
苏州大学 |
一种化学选择性制备多功能吡咯衍生物的新方法
|
KR20160062103A
(ko)
|
2013-09-30 |
2016-06-01 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제의 억제제
|
CN105793255B
(zh)
|
2013-10-04 |
2018-11-16 |
无限药品股份有限公司 |
杂环化合物及其用途
|
US9751888B2
(en)
|
2013-10-04 |
2017-09-05 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
US9775844B2
(en)
|
2014-03-19 |
2017-10-03 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CA2942528A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
US20150320755A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
WO2016019233A1
(en)
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
CN106573002A
(zh)
|
2014-08-07 |
2017-04-19 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶抑制剂的新型制剂
|
WO2016054491A1
(en)
|
2014-10-03 |
2016-04-07 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
RS65234B1
(sr)
|
2015-03-03 |
2024-03-29 |
Pharmacyclics Llc |
Farmaceutske formulacije inhibitora brutonove tirozin kinaze
|
US10550124B2
(en)
|
2015-08-13 |
2020-02-04 |
San Diego State University Foundation |
Atropisomerism for increased kinase inhibitor selectivity
|
WO2017048702A1
(en)
|
2015-09-14 |
2017-03-23 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
US10759806B2
(en)
|
2016-03-17 |
2020-09-01 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
ES2964781T3
(es)
|
2016-06-21 |
2024-04-09 |
Nerviano Medical Sciences Srl |
Derivados de sulfonamida n-fenilsustituida como inhibidores de la cinasa
|
UA125216C2
(uk)
|
2016-06-24 |
2022-02-02 |
Інфініті Фармасьютікалз, Інк. |
Комбінована терапія
|
CN117510405A
(zh)
|
2017-04-18 |
2024-02-06 |
礼来公司 |
苯基-2-羟基-乙酰氨基-2-甲基-苯基化合物
|
JP2021535113A
(ja)
*
|
2018-08-22 |
2021-12-16 |
江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Jiangsu Hengrui Medicine Co., Ltd. |
ピロロ−アミノ−ピリダジノン化合物およびその中間体の調製方法
|
WO2020208139A1
(en)
*
|
2019-04-10 |
2020-10-15 |
Cellestia Biotech Ag |
Inhibitors of notch signalling pathway and use thereof in treatment of cancers
|
PE20220573A1
(es)
|
2019-05-13 |
2022-04-20 |
Relay Therapeutics Inc |
Inhibidores de fgfr y metodos de uso de los mismos
|
CN110483523B
(zh)
*
|
2019-08-27 |
2022-11-22 |
药雅科技(上海)有限公司 |
一种吡唑并嘧啶衍生物表皮生长因子抑制剂及其制备方法与用途
|
CA3152508A1
(en)
*
|
2019-08-29 |
2021-03-04 |
Hibercell, Inc. |
Perk inhibiting pyrrolopyrimidine compounds
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
AU2020436612A1
(en)
|
2020-03-16 |
2022-09-01 |
Flash Therapeutics, Llc |
Compounds for treating or inhibiting recurrence of acute myeloid leukemia
|
TW202233625A
(zh)
*
|
2020-11-18 |
2022-09-01 |
美商傳達治療有限公司 |
Fgfr抑制劑及其製造及使用方法
|
EP4247795A1
(de)
|
2020-11-18 |
2023-09-27 |
Deciphera Pharmaceuticals, LLC |
Gcn2- und perk-kinasehemmer sowie verfahren zur verwendung davon
|
CA3231948A1
(en)
*
|
2021-09-23 |
2023-03-30 |
Jingyu Hu |
Fgfr inhibitors and methods of use thereof
|
WO2023104035A1
(zh)
*
|
2021-12-06 |
2023-06-15 |
英矽智能科技(上海)有限公司 |
取代的单环或双环杂环化合物,其制法与医药上的用途
|
CN116903628A
(zh)
*
|
2022-04-20 |
2023-10-20 |
深圳福沃药业有限公司 |
Fgfr2抑制剂及使用方法
|