DK0566199T3 - 1,2,4-oxadiazolyl-phenoxyalkylisoxazoler og deres anvendelse som antivirale midler - Google Patents

1,2,4-oxadiazolyl-phenoxyalkylisoxazoler og deres anvendelse som antivirale midler

Info

Publication number
DK0566199T3
DK0566199T3 DK93201058T DK93201058T DK0566199T3 DK 0566199 T3 DK0566199 T3 DK 0566199T3 DK 93201058 T DK93201058 T DK 93201058T DK 93201058 T DK93201058 T DK 93201058T DK 0566199 T3 DK0566199 T3 DK 0566199T3
Authority
DK
Denmark
Prior art keywords
alkoxy
alkoxyalkyl
hydroxyalkyl
cycloalkyl
alkylene
Prior art date
Application number
DK93201058T
Other languages
English (en)
Inventor
Guy Dominic Diana
Theodore John Nitz
Original Assignee
Sanofi Synthelabo
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo, Sanofi Sa filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of DK0566199T3 publication Critical patent/DK0566199T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93201058T 1992-04-15 1993-04-13 1,2,4-oxadiazolyl-phenoxyalkylisoxazoler og deres anvendelse som antivirale midler DK0566199T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number Publication Date
DK0566199T3 true DK0566199T3 (da) 2000-06-19

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93201058T DK0566199T3 (da) 1992-04-15 1993-04-13 1,2,4-oxadiazolyl-phenoxyalkylisoxazoler og deres anvendelse som antivirale midler

Country Status (26)

Country Link
US (3) US5349068A (da)
EP (1) EP0566199B1 (da)
JP (1) JP3103845B2 (da)
KR (1) KR100314158B1 (da)
AT (1) ATE189958T1 (da)
AU (1) AU666528B2 (da)
CA (1) CA2094012C (da)
CZ (1) CZ285845B6 (da)
DE (1) DE69327913T2 (da)
DK (1) DK0566199T3 (da)
ES (1) ES2143487T3 (da)
FI (1) FI112229B (da)
GR (1) GR3033486T3 (da)
HU (2) HU220606B1 (da)
IL (1) IL105372A (da)
MX (1) MX9302169A (da)
MY (1) MY110191A (da)
NO (1) NO302700B1 (da)
NZ (1) NZ247411A (da)
PH (1) PH30454A (da)
PT (1) PT566199E (da)
RU (1) RU2114112C1 (da)
SG (1) SG50663A1 (da)
SK (1) SK279786B6 (da)
TW (1) TW239140B (da)
UA (1) UA35557C2 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
EP1406632A4 (en) * 2001-06-08 2009-11-04 Cytovia Inc 3-ARYL-5-ARYL-1,2,4-OXADIAZOLES AND THEIR ANALOGUES, CASPASE ACTIVATORS AND INDUCERS OF APOPTOSIS, AND USES THEREOF
US7129359B2 (en) * 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
WO2003020271A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
US20050027127A1 (en) * 2001-08-29 2005-02-03 Diana Guy D. Oxadiazolyl-phenoxyalkylisoxazoles compositions thereof and methods for their use as anti-picornaviral agents
DK2193792T3 (da) * 2001-12-07 2012-01-02 Ana Maria Sandino Neomycin til forøgelse af overlevelsesraten for vandlevende dyr, der udsættes for IPNV
CA2475971A1 (en) * 2002-02-14 2003-08-21 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
US7144876B2 (en) * 2002-12-18 2006-12-05 Cytovia, Inc. 3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
US20060030550A1 (en) * 2004-08-04 2006-02-09 Lithgow Theodore L Pharmaceutical formulations
WO2007095039A2 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
MX2008010350A (es) * 2006-02-09 2008-10-31 Schering Corp Formulaciones farmaceuticas.
EP1981475A2 (en) * 2006-02-09 2008-10-22 Schering Corporation Pharmaceutical formulations
KR101475091B1 (ko) 2006-12-13 2014-12-22 에프. 호프만-라 로슈 아게 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
CN112752761B (zh) 2018-08-21 2024-03-29 杏林制药株式会社 双环杂芳族环衍生物
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
CA2094012C (en) 2001-08-21
MX9302169A (es) 1993-10-01
FI931707A0 (fi) 1993-04-15
US5349068A (en) 1994-09-20
MY110191A (en) 1998-02-28
UA35557C2 (uk) 2001-04-16
HU220606B1 (hu) 2002-03-28
CA2094012A1 (en) 1993-10-16
FI112229B (fi) 2003-11-14
AU3688193A (en) 1993-10-21
US5643929A (en) 1997-07-01
EP0566199B1 (en) 2000-03-01
JP3103845B2 (ja) 2000-10-30
DE69327913T2 (de) 2000-10-12
ATE189958T1 (de) 2000-03-15
US5464848A (en) 1995-11-07
FI931707A (fi) 1993-10-16
DE69327913D1 (de) 2000-04-06
SK35393A3 (en) 1994-06-08
ES2143487T3 (es) 2000-05-16
NO302700B1 (no) 1998-04-14
AU666528B2 (en) 1996-02-15
IL105372A (en) 1998-12-27
PH30454A (en) 1997-05-28
CZ59793A3 (en) 1994-02-16
CZ285845B6 (cs) 1999-11-17
NO931366L (no) 1993-10-18
GR3033486T3 (en) 2000-09-29
IL105372A0 (en) 1993-08-18
HU211320A9 (en) 1995-11-28
HU9301084D0 (en) 1993-06-28
RU2114112C1 (ru) 1998-06-27
SK279786B6 (sk) 1999-03-12
TW239140B (da) 1995-01-21
HUT65574A (en) 1994-07-28
NO931366D0 (no) 1993-04-14
SG50663A1 (en) 1998-07-20
NZ247411A (en) 1994-06-27
JPH0649066A (ja) 1994-02-22
KR100314158B1 (ko) 2002-02-19
EP0566199A1 (en) 1993-10-20
KR930021637A (ko) 1993-11-22
PT566199E (pt) 2000-09-29

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