ES2143487T3 - 1,2,4-oxadiazolil-fenoxialquilisoxazoles y su empleo como agentes antivirales. - Google Patents

1,2,4-oxadiazolil-fenoxialquilisoxazoles y su empleo como agentes antivirales.

Info

Publication number
ES2143487T3
ES2143487T3 ES93201058T ES93201058T ES2143487T3 ES 2143487 T3 ES2143487 T3 ES 2143487T3 ES 93201058 T ES93201058 T ES 93201058T ES 93201058 T ES93201058 T ES 93201058T ES 2143487 T3 ES2143487 T3 ES 2143487T3
Authority
ES
Spain
Prior art keywords
alkoxy
antiviral agents
alkoxyalkyl
hydroxyalkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93201058T
Other languages
English (en)
Inventor
Guy Dominic Diana
Theodore John Nitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2143487T3 publication Critical patent/ES2143487T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) EN DONDE: R1 ES ALKILO, ALCOXI, HIDROXI, CICLOALKILO, HIDROXIALKILO, ALCOXIALKILO O HIDROXIALCOXI; Y ES ALKILENO DE 3 A 9 ATOMOS DE CARBONO, R2 Y R3 SON, INDEPENDIENTEMENTE, HIDROGENO, ALKILO, ALCOXI, HALO, TRIFLUOMETILO O NITRO; R4 ES ALCOXI, HIDROXI, HALOMETILO, DIHALOMETILO, TRIHALOMETILO, CICLOALKILO, ALCOXICARBONILO, HIDROXIALKILO, ALCOXIALKILO, ALKANOCARBONILOXIALKILO, CIANO, 2,2,2-TRIFLUORETILO, (4METILFENIL)SULFONILOXIMETILO, N=Q O CON=Q, DONDE N=Q ES AMINO, ALKILAMINO O DIALKILAMINO; O LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE SON UTILES COMO AGENTES ANTIVIRALES. LOS COMPUESTOS PREFERENTES SON AQUELLOS EN DONDE Y ES ALKILENO DE 3 A 5 ATOMOS DE CARBONO Y ESPECIALMENTE AQUELLOS EN QUE R2 Y R3 SE ENCUENTRAN EN LAS POSICIONES 2 Y 6 DEL ANILLO DE FENILO.
ES93201058T 1992-04-15 1993-04-13 1,2,4-oxadiazolil-fenoxialquilisoxazoles y su empleo como agentes antivirales. Expired - Lifetime ES2143487T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number Publication Date
ES2143487T3 true ES2143487T3 (es) 2000-05-16

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93201058T Expired - Lifetime ES2143487T3 (es) 1992-04-15 1993-04-13 1,2,4-oxadiazolil-fenoxialquilisoxazoles y su empleo como agentes antivirales.

Country Status (26)

Country Link
US (3) US5349068A (es)
EP (1) EP0566199B1 (es)
JP (1) JP3103845B2 (es)
KR (1) KR100314158B1 (es)
AT (1) ATE189958T1 (es)
AU (1) AU666528B2 (es)
CA (1) CA2094012C (es)
CZ (1) CZ285845B6 (es)
DE (1) DE69327913T2 (es)
DK (1) DK0566199T3 (es)
ES (1) ES2143487T3 (es)
FI (1) FI112229B (es)
GR (1) GR3033486T3 (es)
HU (2) HU220606B1 (es)
IL (1) IL105372A (es)
MX (1) MX9302169A (es)
MY (1) MY110191A (es)
NO (1) NO302700B1 (es)
NZ (1) NZ247411A (es)
PH (1) PH30454A (es)
PT (1) PT566199E (es)
RU (1) RU2114112C1 (es)
SG (1) SG50663A1 (es)
SK (1) SK279786B6 (es)
TW (1) TW239140B (es)
UA (1) UA35557C2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
US7041685B2 (en) * 2001-06-08 2006-05-09 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
WO2003020271A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
CA2459375A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
ATE465730T1 (de) * 2001-12-07 2010-05-15 Ana Maria Sandino Zusammensetzungen zur steigerung des überlebens von wassertieren, die einem rns-virus ausgesetzt sind
WO2003068222A1 (en) * 2002-02-14 2003-08-21 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
WO2004058253A1 (en) * 2002-12-18 2004-07-15 Cytovia, Inc. 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
EP1819329A2 (en) * 2004-08-04 2007-08-22 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
CA2641604A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
EP1981476A2 (en) * 2006-02-09 2008-10-22 Schering Corporation Pharmaceutical formulations
MX2008010353A (es) * 2006-02-09 2009-03-05 Schering Corp Formulaciones farmaceuticas.
KR101475091B1 (ko) 2006-12-13 2014-12-22 에프. 호프만-라 로슈 아게 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
MX2020013039A (es) 2018-08-21 2021-02-26 Kyorin Seiyaku Kk Derivado de anillo heteroaromatico biciclico.
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
UA35557C2 (uk) 2001-04-16
NO931366L (no) 1993-10-18
DE69327913D1 (de) 2000-04-06
NO931366D0 (no) 1993-04-14
IL105372A (en) 1998-12-27
JP3103845B2 (ja) 2000-10-30
MX9302169A (es) 1993-10-01
DK0566199T3 (da) 2000-06-19
GR3033486T3 (en) 2000-09-29
HU211320A9 (en) 1995-11-28
EP0566199B1 (en) 2000-03-01
KR100314158B1 (ko) 2002-02-19
MY110191A (en) 1998-02-28
IL105372A0 (en) 1993-08-18
AU3688193A (en) 1993-10-21
AU666528B2 (en) 1996-02-15
RU2114112C1 (ru) 1998-06-27
JPH0649066A (ja) 1994-02-22
FI112229B (fi) 2003-11-14
FI931707A (fi) 1993-10-16
HU9301084D0 (en) 1993-06-28
SG50663A1 (en) 1998-07-20
KR930021637A (ko) 1993-11-22
DE69327913T2 (de) 2000-10-12
FI931707A0 (fi) 1993-04-15
CA2094012C (en) 2001-08-21
US5349068A (en) 1994-09-20
TW239140B (es) 1995-01-21
NZ247411A (en) 1994-06-27
PT566199E (pt) 2000-09-29
HU220606B1 (hu) 2002-03-28
EP0566199A1 (en) 1993-10-20
NO302700B1 (no) 1998-04-14
ATE189958T1 (de) 2000-03-15
SK279786B6 (sk) 1999-03-12
CZ59793A3 (en) 1994-02-16
US5464848A (en) 1995-11-07
PH30454A (en) 1997-05-28
SK35393A3 (en) 1994-06-08
CA2094012A1 (en) 1993-10-16
US5643929A (en) 1997-07-01
CZ285845B6 (cs) 1999-11-17
HUT65574A (en) 1994-07-28

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