ES8303415A1 - Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-6) (1,5) benzodiazepina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-6) (1,5) benzodiazepina.

Info

Publication number
ES8303415A1
ES8303415A1 ES507863A ES507863A ES8303415A1 ES 8303415 A1 ES8303415 A1 ES 8303415A1 ES 507863 A ES507863 A ES 507863A ES 507863 A ES507863 A ES 507863A ES 8303415 A1 ES8303415 A1 ES 8303415A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
formula
cycloalkyl
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507863A
Other languages
English (en)
Other versions
ES507863A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of ES8303415A1 publication Critical patent/ES8303415A1/es
Publication of ES507863A0 publication Critical patent/ES507863A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3-TRIAZOLO 4,5-B 1,5 BENZODIAZEPINA Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I) EN LA QUE R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA AMINA DE FORMULA R H CON UN COMPUESTO DE FORMULA (II), EN LAS QUE R -R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); R TIENE LA FORMULA (III), DONDE R ES ALQUILO C <- O HIDROGENO, R ES ALQUILO C Q<- O HIDROGENO Y N VALE 0 O 1; R PUEDE SER VARIOS RADICALES; Y Q ES UN GRUPO DESPLAZABLE POR EL ATOMO DE HIDROGENO DE LA AMINA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL.
ES507863A 1980-12-11 1981-12-10 Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-6) (1,5) benzodiazepina. Granted ES507863A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8039659 1980-12-11

Publications (2)

Publication Number Publication Date
ES8303415A1 true ES8303415A1 (es) 1983-02-01
ES507863A0 ES507863A0 (es) 1983-02-01

Family

ID=10517899

Family Applications (2)

Application Number Title Priority Date Filing Date
ES507863A Granted ES507863A0 (es) 1980-12-11 1981-12-10 Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-6) (1,5) benzodiazepina.
ES516582A Expired ES8401073A1 (es) 1980-12-11 1982-10-15 Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-b) 1,5) benzodiazpezina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES516582A Expired ES8401073A1 (es) 1980-12-11 1982-10-15 Un procedimiento para la preparacion de nuevos derivados de 3-triazolo (4,5-b) 1,5) benzodiazpezina.

Country Status (29)

Country Link
US (2) US4431589A (es)
EP (1) EP0054416B1 (es)
JP (1) JPS57122087A (es)
KR (1) KR880000045B1 (es)
AR (1) AR229600A1 (es)
AT (1) ATE9093T1 (es)
AU (1) AU550943B2 (es)
BG (1) BG36935A3 (es)
CA (1) CA1167839A (es)
CS (1) CS227025B2 (es)
DD (1) DD208153A5 (es)
DE (1) DE3165712D1 (es)
DK (1) DK155940C (es)
EG (1) EG15462A (es)
ES (2) ES507863A0 (es)
FI (1) FI71150C (es)
GB (1) GB2091246B (es)
GR (1) GR74710B (es)
HU (1) HU183733B (es)
IE (1) IE51770B1 (es)
IL (1) IL64489A0 (es)
MX (1) MX6710E (es)
NZ (1) NZ199186A (es)
PH (1) PH17295A (es)
PL (2) PL131762B1 (es)
PT (1) PT74104B (es)
RO (1) RO84100B (es)
SU (2) SU1170971A3 (es)
ZA (1) ZA818586B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134842A1 (de) * 1981-09-03 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Neue anilino-1,2,3-triazol-derivate, diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung
US4595535A (en) * 1983-06-06 1986-06-17 Ciba-Geigy Corporation Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents
DE3331858A1 (de) * 1983-09-03 1985-03-21 Boehringer Ingelheim KG, 6507 Ingelheim Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
EP1492794B1 (en) * 2002-03-28 2007-12-12 Eli Lilly And Company Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders
US8146310B2 (en) * 2009-03-11 2012-04-03 Keene Building Products Co., Inc. Noise control flooring system
US8528286B2 (en) * 2009-11-10 2013-09-10 Keene Building Products Co., Inc. Sound control mat
AU2014291142B2 (en) 2013-07-17 2018-10-11 Otsuka Pharmaceutical Co., Ltd. Cyanotriazole compounds

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH468400A (de) * 1965-12-23 1969-02-15 Sandoz Ag Verfahren zur Herstellung neuer Thieno(2,3-b)(1,5)benzothiazepin-4-on-Verbindungen
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
US3793325A (en) * 1967-03-22 1974-02-19 Sandoz Ag 11-basically substituted dibenz(b,f)(1,4)thiazepine and dibenz(b,e)(1,4)diazepines
US3758479A (en) * 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
CH491956A (de) * 1967-11-30 1970-06-15 Geigy Ag J R Verfahren zur Herstellung von neuen Thiazepinderivaten
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
GB1292410A (en) * 1970-05-13 1972-10-11 Yoshitomi Pharmaceutical Thienobenzothiazepine derivatives
BE791902A (fr) * 1971-11-26 1973-05-24 Wander Ag Dr A Nouveaux derives de la thieno (3,2-c) (1)benzazepine, leur preparation et leur application comme medicaments
US3962248A (en) * 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
NL7403657A (es) * 1973-03-23 1974-09-25
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US4172831A (en) * 1974-11-26 1979-10-30 Lilly Industries Limited Thieno-benzodiazepines
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
US3951981A (en) * 1975-02-24 1976-04-20 American Cyanamid Company Substituted benzodiazepines and method of use
DE2707270A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Pyrazolo-diazepine und verfahren zu ihrer herstellung
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
NZ194529A (en) * 1979-08-03 1983-05-10 Byk Gulden Lomberg Chem Fab 9,10-dihydro-1h, 4h-pyrazolo (4,3-b)(1,5)benzodiazepin-10-ones
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Also Published As

Publication number Publication date
IE812890L (en) 1982-06-11
ES516582A0 (es) 1983-11-16
JPS57122087A (en) 1982-07-29
PH17295A (en) 1984-07-12
ZA818586B (en) 1983-07-27
PL131762B1 (en) 1984-12-31
GB2091246B (en) 1985-01-30
EP0054416A3 (en) 1982-09-08
AU550943B2 (en) 1986-04-10
FI71150C (fi) 1986-11-24
GB2091246A (en) 1982-07-28
PT74104A (en) 1982-01-01
DK155940B (da) 1989-06-05
KR880000045B1 (ko) 1988-02-20
IE51770B1 (en) 1987-03-18
KR830007655A (ko) 1983-11-04
DD208153A5 (de) 1984-03-28
AU7844081A (en) 1982-06-17
EP0054416B1 (en) 1984-08-22
EG15462A (en) 1990-10-30
EP0054416A2 (en) 1982-06-23
MX6710E (es) 1985-10-30
RO84100B (ro) 1984-06-30
HU183733B (en) 1984-05-28
US4492699A (en) 1985-01-08
PL136930B1 (en) 1986-04-30
PT74104B (en) 1983-05-16
US4431589A (en) 1984-02-14
DK155940C (da) 1989-10-23
DK548281A (da) 1982-06-12
CA1167839A (en) 1984-05-22
NZ199186A (en) 1984-11-09
DE3165712D1 (en) 1984-09-27
SU1169538A3 (ru) 1985-07-23
ES8401073A1 (es) 1983-11-16
ATE9093T1 (de) 1984-09-15
JPH0337555B2 (es) 1991-06-05
AR229600A1 (es) 1983-09-30
BG36935A3 (en) 1985-02-15
PL234173A1 (en) 1983-01-17
CS227025B2 (en) 1984-04-16
ES507863A0 (es) 1983-02-01
RO84100A (ro) 1984-05-12
PL238268A1 (en) 1983-04-11
GR74710B (es) 1984-07-06
FI813892L (fi) 1982-06-12
FI71150B (fi) 1986-08-14
SU1170971A3 (ru) 1985-07-30
IL64489A0 (en) 1982-03-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401