MA35024B1 - Dérivés de pyrrolo-[2,3-d]pyrimidine servant d'inhibiteurs des kinases apparentés à la tropomyosine - Google Patents
Dérivés de pyrrolo-[2,3-d]pyrimidine servant d'inhibiteurs des kinases apparentés à la tropomyosineInfo
- Publication number
- MA35024B1 MA35024B1 MA36302A MA36302A MA35024B1 MA 35024 B1 MA35024 B1 MA 35024B1 MA 36302 A MA36302 A MA 36302A MA 36302 A MA36302 A MA 36302A MA 35024 B1 MA35024 B1 MA 35024B1
- Authority
- MA
- Morocco
- Prior art keywords
- tropomyosin
- pyrrolo
- inhibitors
- pyrimidine derivatives
- related kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, les substituants étant tels que décrits dans le présent document, et leur utilisation en médecine, en particulier tant qu'antagonistes de la Trk.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471758P | 2011-04-05 | 2011-04-05 | |
PCT/IB2012/051363 WO2012137089A1 (fr) | 2011-04-05 | 2012-03-22 | Dérivés de pyrrolo-[2,3-d]pyrimidine en tant qu'inhibiteurs des kinases associées à la tropomyosine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35024B1 true MA35024B1 (fr) | 2014-04-03 |
Family
ID=45937493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36302A MA35024B1 (fr) | 2011-04-05 | 2012-03-22 | Dérivés de pyrrolo-[2,3-d]pyrimidine servant d'inhibiteurs des kinases apparentés à la tropomyosine |
Country Status (31)
Country | Link |
---|---|
US (2) | US8846698B2 (fr) |
EP (1) | EP2694509B1 (fr) |
JP (1) | JP5595616B2 (fr) |
KR (1) | KR20130133905A (fr) |
CN (1) | CN103534257A (fr) |
AP (1) | AP2013007159A0 (fr) |
AR (1) | AR085852A1 (fr) |
AU (1) | AU2012238369A1 (fr) |
BR (1) | BR112013025792A2 (fr) |
CA (1) | CA2832291C (fr) |
CL (1) | CL2013002821A1 (fr) |
CO (1) | CO6801740A2 (fr) |
CR (1) | CR20130470A (fr) |
CU (1) | CU20130129A7 (fr) |
DO (1) | DOP2013000221A (fr) |
EA (1) | EA201391239A1 (fr) |
EC (1) | ECSP13013009A (fr) |
ES (1) | ES2581848T3 (fr) |
GE (1) | GEP20156417B (fr) |
GT (1) | GT201300236A (fr) |
IL (1) | IL228590A0 (fr) |
MA (1) | MA35024B1 (fr) |
MX (1) | MX2013011612A (fr) |
NI (1) | NI201300103A (fr) |
PE (1) | PE20141050A1 (fr) |
SG (1) | SG193513A1 (fr) |
TN (1) | TN2013000394A1 (fr) |
TW (1) | TWI443101B (fr) |
UA (1) | UA108926C2 (fr) |
UY (1) | UY34004A (fr) |
WO (1) | WO2012137089A1 (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2873060A1 (fr) * | 2012-05-11 | 2013-11-14 | Abbvie Inc. | Inhibiteurs de nampt |
CA2885253A1 (fr) | 2012-10-04 | 2014-04-10 | Pfizer Limited | Inhibiteurs de kinase associee a la tropomyosine pyrrolo[2,3-d]pyrimidine |
US20150250785A1 (en) * | 2012-10-04 | 2015-09-10 | Pfizer Limited | Tropomyosin-Related Kinase Inhibitors |
JP2015531395A (ja) | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドPfizer Limited | ピロロ[3,2−c]ピリジントロポミオシン関連キナーゼ阻害剤 |
US9278950B2 (en) | 2013-01-14 | 2016-03-08 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
EA035929B1 (ru) | 2013-01-15 | 2020-09-02 | Инсайт Холдингс Корпорейшн | ТИАЗОЛКАРБОКСАМИДЫ И ПИРИДИНКАРБОКСАМИДЫ, ИСПОЛЬЗУЕМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Pim-КИНАЗЫ |
US9447025B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
MX2016002367A (es) | 2013-08-23 | 2016-10-28 | Incyte Corp | Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim. |
US9067914B1 (en) | 2013-12-10 | 2015-06-30 | Genzyme Corporation | Tropomyosin-related kinase (TRK) inhibitors |
CN105814013A (zh) | 2013-12-12 | 2016-07-27 | 卡利拉制药公司 | 双环烷基化合物及合成 |
WO2015092610A1 (fr) | 2013-12-20 | 2015-06-25 | Pfizer Limited | Inhibiteurs de kinase apparentés à la n-acylpipéridine éther tropomyosine |
CA2937074A1 (fr) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | Derives furo-3-carboxamide et methodes d'utilisation |
CN109820853B (zh) * | 2014-02-05 | 2022-05-10 | Vm肿瘤药物有限责任公司 | 取代的杂环化合物在制备治疗癌症药物中的用途 |
JP6741343B2 (ja) | 2014-03-07 | 2020-08-19 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | プロペラン誘導体および合成 |
WO2015143654A1 (fr) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions et méthodes associées |
EP3140298A1 (fr) * | 2014-05-07 | 2017-03-15 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la tropomyosine |
CN103992319B (zh) * | 2014-05-27 | 2015-09-16 | 天津市斯芬克司药物研发有限公司 | 一种吡啶羧酸类化合物的制备方法 |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016009296A1 (fr) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | Inhibiteurs de kinase liés à la n-acylpipéridine éther tropomyosine |
WO2016020784A1 (fr) | 2014-08-05 | 2016-02-11 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la n-acylpyrrolidine éther tropomyosine |
JP6833677B2 (ja) * | 2014-09-17 | 2021-02-24 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 二環式化合物 |
BR112017012566B1 (pt) | 2014-12-18 | 2024-01-30 | Genzyme Corporation | Forma cristalina monohidratada, composição e formulações farmacêuticas de inibidores de cinases relacionadas à tropomiosina (trk) |
JP6675324B2 (ja) * | 2014-12-24 | 2020-04-01 | 武田薬品工業株式会社 | 複素環化合物 |
CN105837574B (zh) * | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
WO2017027883A1 (fr) | 2015-08-13 | 2017-02-16 | San Diego State University Research Foundation | Atropisomérisme pour une sélectivité accrue des inhibiteurs de kinase |
TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Pim激酶抑制劑之鹽 |
RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
WO2017220516A1 (fr) * | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Dérivés de triazolo[4,5-d]pyrimidine |
CN107011347B (zh) * | 2017-04-18 | 2019-01-18 | 华东师范大学 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法 |
CA3063729A1 (fr) | 2017-05-15 | 2018-11-22 | Recurium Ip Holdings, Llc | Composes analgesiques |
WO2018237134A1 (fr) | 2017-06-23 | 2018-12-27 | San Diego State University Research Foundation | Atropisomérisme pour une sélectivité améliorée des inhibiteurs de kinase |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
US10807987B2 (en) * | 2018-03-28 | 2020-10-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
CN109053575A (zh) * | 2018-08-24 | 2018-12-21 | 遵义医学院 | 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺 |
WO2020084389A1 (fr) * | 2018-10-23 | 2020-04-30 | Lupin Limited | Intermédiaire de ribociclib et son procédé de préparation |
EP3897670A4 (fr) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | Inhibiteurs de sarm1 en combinaison avec des agents neuroprotecteurs |
CA3129665A1 (fr) | 2019-03-21 | 2020-09-24 | Onxeo | Molecule dbait associee a un inhibiteur de kinase pour le traitement du cancer |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
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CN115043844B (zh) * | 2021-06-21 | 2024-05-17 | 河南迈英诺医药科技有限公司 | Trk激酶抑制剂化合物及其用途 |
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CN101808994B (zh) | 2007-07-17 | 2013-05-15 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
WO2009143018A2 (fr) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Composés et procédés de modulation des kinases, et indications associées |
PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
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KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
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2012
- 2012-03-22 PE PE2013002178A patent/PE20141050A1/es not_active Application Discontinuation
- 2012-03-22 EP EP12713362.7A patent/EP2694509B1/fr active Active
- 2012-03-22 GE GEAP201213253A patent/GEP20156417B/en unknown
- 2012-03-22 AP AP2013007159A patent/AP2013007159A0/xx unknown
- 2012-03-22 WO PCT/IB2012/051363 patent/WO2012137089A1/fr active Application Filing
- 2012-03-22 SG SG2013070032A patent/SG193513A1/en unknown
- 2012-03-22 MX MX2013011612A patent/MX2013011612A/es unknown
- 2012-03-22 MA MA36302A patent/MA35024B1/fr unknown
- 2012-03-22 UA UAA201311548A patent/UA108926C2/ru unknown
- 2012-03-22 AU AU2012238369A patent/AU2012238369A1/en not_active Abandoned
- 2012-03-22 BR BR112013025792A patent/BR112013025792A2/pt not_active IP Right Cessation
- 2012-03-22 JP JP2014503236A patent/JP5595616B2/ja not_active Expired - Fee Related
- 2012-03-22 CA CA2832291A patent/CA2832291C/fr not_active Expired - Fee Related
- 2012-03-22 EA EA201391239A patent/EA201391239A1/ru unknown
- 2012-03-22 KR KR1020137029237A patent/KR20130133905A/ko active IP Right Grant
- 2012-03-22 CN CN201280022159.2A patent/CN103534257A/zh active Pending
- 2012-03-22 ES ES12713362.7T patent/ES2581848T3/es active Active
- 2012-03-30 UY UY0001034004A patent/UY34004A/es not_active Application Discontinuation
- 2012-04-02 TW TW101111719A patent/TWI443101B/zh not_active IP Right Cessation
- 2012-04-04 AR ARP120101171A patent/AR085852A1/es unknown
- 2012-04-04 US US13/439,131 patent/US8846698B2/en not_active Expired - Fee Related
-
2013
- 2013-09-17 CR CR20130470A patent/CR20130470A/es unknown
- 2013-09-27 TN TNP2013000394A patent/TN2013000394A1/fr unknown
- 2013-09-29 IL IL228590A patent/IL228590A0/en unknown
- 2013-09-30 CU CU2013000129A patent/CU20130129A7/es unknown
- 2013-09-30 CL CL2013002821A patent/CL2013002821A1/es unknown
- 2013-10-03 NI NI201300103A patent/NI201300103A/es unknown
- 2013-10-04 GT GT201300236A patent/GT201300236A/es unknown
- 2013-10-04 CO CO13236624A patent/CO6801740A2/es active IP Right Grant
- 2013-10-04 DO DO2013000221A patent/DOP2013000221A/es unknown
- 2013-11-05 EC ECSP13013009 patent/ECSP13013009A/es unknown
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2014
- 2014-08-26 US US14/468,614 patent/US20140364415A1/en not_active Abandoned
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