AP2013007159A0 - Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of tropomyosin-related kinase - Google Patents
Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of tropomyosin-related kinaseInfo
- Publication number
- AP2013007159A0 AP2013007159A0 AP2013007159A AP2013007159A AP2013007159A0 AP 2013007159 A0 AP2013007159 A0 AP 2013007159A0 AP 2013007159 A AP2013007159 A AP 2013007159A AP 2013007159 A AP2013007159 A AP 2013007159A AP 2013007159 A0 AP2013007159 A0 AP 2013007159A0
- Authority
- AP
- ARIPO
- Prior art keywords
- tropomyosin
- pyrrolo
- inhibitors
- pyrimidine derivatives
- related kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471758P | 2011-04-05 | 2011-04-05 | |
PCT/IB2012/051363 WO2012137089A1 (fr) | 2011-04-05 | 2012-03-22 | Dérivés de pyrrolo-[2,3-d]pyrimidine en tant qu'inhibiteurs des kinases associées à la tropomyosine |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2013007159A0 true AP2013007159A0 (en) | 2013-10-31 |
Family
ID=45937493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2013007159A AP2013007159A0 (en) | 2011-04-05 | 2012-03-22 | Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of tropomyosin-related kinase |
Country Status (31)
Country | Link |
---|---|
US (2) | US8846698B2 (fr) |
EP (1) | EP2694509B1 (fr) |
JP (1) | JP5595616B2 (fr) |
KR (1) | KR20130133905A (fr) |
CN (1) | CN103534257A (fr) |
AP (1) | AP2013007159A0 (fr) |
AR (1) | AR085852A1 (fr) |
AU (1) | AU2012238369A1 (fr) |
BR (1) | BR112013025792A2 (fr) |
CA (1) | CA2832291C (fr) |
CL (1) | CL2013002821A1 (fr) |
CO (1) | CO6801740A2 (fr) |
CR (1) | CR20130470A (fr) |
CU (1) | CU20130129A7 (fr) |
DO (1) | DOP2013000221A (fr) |
EA (1) | EA201391239A1 (fr) |
EC (1) | ECSP13013009A (fr) |
ES (1) | ES2581848T3 (fr) |
GE (1) | GEP20156417B (fr) |
GT (1) | GT201300236A (fr) |
IL (1) | IL228590A0 (fr) |
MA (1) | MA35024B1 (fr) |
MX (1) | MX2013011612A (fr) |
NI (1) | NI201300103A (fr) |
PE (1) | PE20141050A1 (fr) |
SG (1) | SG193513A1 (fr) |
TN (1) | TN2013000394A1 (fr) |
TW (1) | TWI443101B (fr) |
UA (1) | UA108926C2 (fr) |
UY (1) | UY34004A (fr) |
WO (1) | WO2012137089A1 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20150007349A (ko) * | 2012-05-11 | 2015-01-20 | 애브비 인코포레이티드 | Nampt 억제제 |
EP2912036A1 (fr) | 2012-10-04 | 2015-09-02 | Pfizer Limited | Inhibiteurs de kinase associée à la tropomyosine pyrrolo[3,2-c]pyridine |
US20150250785A1 (en) * | 2012-10-04 | 2015-09-10 | Pfizer Limited | Tropomyosin-Related Kinase Inhibitors |
JP2015531394A (ja) | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドPfizer Limited | ピロロ[2,3−d]ピリミジントロポミオシン関連キナーゼ阻害剤 |
US9278950B2 (en) | 2013-01-14 | 2016-03-08 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
BR122019024759B1 (pt) | 2013-01-15 | 2022-02-08 | Incyte Holdings Corporation | Compostos de tiazolacarboxamidas e piridinacarboxamida, composição compreendendo os mesmos, método de inibição da enzima pim1, pim2, ou pim3, e usos dos referidos compostos |
CA2903431C (fr) | 2013-03-14 | 2022-12-06 | Kalyra Pharmaceuticals, Inc. | Composes analgesiques bicyclopentanes |
JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
JP2016528298A (ja) | 2013-08-23 | 2016-09-15 | インサイト・コーポレイションIncyte Corporation | Pimキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物 |
TWI731317B (zh) | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
EP3080072A4 (fr) | 2013-12-12 | 2017-07-19 | Kalyra Pharmaceuticals, inc. | Composés d'alkyle bicyclique et synthèse |
EP3083602A1 (fr) | 2013-12-20 | 2016-10-26 | Pfizer Limited | Inhibiteurs de kinase apparentés à la n-acylpipéridine éther tropomyosine |
WO2015112754A1 (fr) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | Dérivés furo-3-carboxamide et méthodes d'utilisation |
SI3102555T1 (sl) * | 2014-02-05 | 2021-11-30 | VM Oncology LLC | Sestavki spojin in njihove uporabe |
JP6741343B2 (ja) | 2014-03-07 | 2020-08-19 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | プロペラン誘導体および合成 |
WO2015143654A1 (fr) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions et méthodes associées |
EP3140298A1 (fr) * | 2014-05-07 | 2017-03-15 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la tropomyosine |
CN103992319B (zh) * | 2014-05-27 | 2015-09-16 | 天津市斯芬克司药物研发有限公司 | 一种吡啶羧酸类化合物的制备方法 |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016010897A1 (fr) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Composés carboxamide hétéroaromatiques bicycliques utiles en tant qu'inhibiteurs de kinases pim |
WO2016009296A1 (fr) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | Inhibiteurs de kinase liés à la n-acylpipéridine éther tropomyosine |
WO2016020784A1 (fr) | 2014-08-05 | 2016-02-11 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la n-acylpyrrolidine éther tropomyosine |
JP6833677B2 (ja) * | 2014-09-17 | 2021-02-24 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 二環式化合物 |
TWI780438B (zh) | 2014-12-18 | 2022-10-11 | 美商健臻公司 | 原肌球蛋白相關激酶(trk)抑制劑之醫藥調配物 |
EP3239150B1 (fr) * | 2014-12-24 | 2020-02-05 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
CN105837574B (zh) * | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
US10550124B2 (en) | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Pim激酶抑制劑之鹽 |
KR102161364B1 (ko) | 2015-09-14 | 2020-09-29 | 화이자 인코포레이티드 | LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체 |
US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
WO2017220516A1 (fr) * | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Dérivés de triazolo[4,5-d]pyrimidine |
CN107011347B (zh) * | 2017-04-18 | 2019-01-18 | 华东师范大学 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法 |
AU2018269755B2 (en) | 2017-05-15 | 2022-06-16 | Recurium Ip Holdings, Llc | Analgesic compounds |
WO2018237134A1 (fr) | 2017-06-23 | 2018-12-27 | San Diego State University Research Foundation | Atropisomérisme pour une sélectivité améliorée des inhibiteurs de kinase |
WO2019113487A1 (fr) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs |
WO2019189945A1 (fr) * | 2018-03-28 | 2019-10-03 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique et son utilisation |
CN109053575A (zh) * | 2018-08-24 | 2018-12-21 | 遵义医学院 | 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺 |
WO2020084389A1 (fr) * | 2018-10-23 | 2020-04-30 | Lupin Limited | Intermédiaire de ribociclib et son procédé de préparation |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
WO2021089791A1 (fr) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase |
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EP4357347A1 (fr) * | 2021-06-21 | 2024-04-24 | Henan Medinno Pharmaceutical Technology Co., Ltd. | Composé inhibiteur de la kinase trk et son utilisation |
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-
2012
- 2012-03-22 WO PCT/IB2012/051363 patent/WO2012137089A1/fr active Application Filing
- 2012-03-22 JP JP2014503236A patent/JP5595616B2/ja not_active Expired - Fee Related
- 2012-03-22 CA CA2832291A patent/CA2832291C/fr not_active Expired - Fee Related
- 2012-03-22 ES ES12713362.7T patent/ES2581848T3/es active Active
- 2012-03-22 UA UAA201311548A patent/UA108926C2/ru unknown
- 2012-03-22 AP AP2013007159A patent/AP2013007159A0/xx unknown
- 2012-03-22 BR BR112013025792A patent/BR112013025792A2/pt not_active IP Right Cessation
- 2012-03-22 SG SG2013070032A patent/SG193513A1/en unknown
- 2012-03-22 EP EP12713362.7A patent/EP2694509B1/fr active Active
- 2012-03-22 PE PE2013002178A patent/PE20141050A1/es not_active Application Discontinuation
- 2012-03-22 KR KR1020137029237A patent/KR20130133905A/ko active IP Right Grant
- 2012-03-22 AU AU2012238369A patent/AU2012238369A1/en not_active Abandoned
- 2012-03-22 GE GEAP201213253A patent/GEP20156417B/en unknown
- 2012-03-22 EA EA201391239A patent/EA201391239A1/ru unknown
- 2012-03-22 CN CN201280022159.2A patent/CN103534257A/zh active Pending
- 2012-03-22 MA MA36302A patent/MA35024B1/fr unknown
- 2012-03-22 MX MX2013011612A patent/MX2013011612A/es unknown
- 2012-03-30 UY UY0001034004A patent/UY34004A/es not_active Application Discontinuation
- 2012-04-02 TW TW101111719A patent/TWI443101B/zh not_active IP Right Cessation
- 2012-04-04 AR ARP120101171A patent/AR085852A1/es unknown
- 2012-04-04 US US13/439,131 patent/US8846698B2/en not_active Expired - Fee Related
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2013
- 2013-09-17 CR CR20130470A patent/CR20130470A/es unknown
- 2013-09-27 TN TNP2013000394A patent/TN2013000394A1/fr unknown
- 2013-09-29 IL IL228590A patent/IL228590A0/en unknown
- 2013-09-30 CL CL2013002821A patent/CL2013002821A1/es unknown
- 2013-09-30 CU CU2013000129A patent/CU20130129A7/es unknown
- 2013-10-03 NI NI201300103A patent/NI201300103A/es unknown
- 2013-10-04 GT GT201300236A patent/GT201300236A/es unknown
- 2013-10-04 DO DO2013000221A patent/DOP2013000221A/es unknown
- 2013-10-04 CO CO13236624A patent/CO6801740A2/es active IP Right Grant
- 2013-11-05 EC ECSP13013009 patent/ECSP13013009A/es unknown
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2014
- 2014-08-26 US US14/468,614 patent/US20140364415A1/en not_active Abandoned
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