AR035525A1 - Compuestos utiles como agentes antifungicos, composicion farmaceutica, usos de los compuestos y proceso para prepararlos - Google Patents
Compuestos utiles como agentes antifungicos, composicion farmaceutica, usos de los compuestos y proceso para prepararlosInfo
- Publication number
- AR035525A1 AR035525A1 ARP010106040A ARP010106040A AR035525A1 AR 035525 A1 AR035525 A1 AR 035525A1 AR P010106040 A ARP010106040 A AR P010106040A AR P010106040 A ARP010106040 A AR P010106040A AR 035525 A1 AR035525 A1 AR 035525A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- hydrogen
- alkoxy
- carboxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de compuestos de azole especialmente sustituidos que han mejorado la actividad antifúngica comparada con los agentes disponibles actualmente en esta clase de procesos para la preparación de los mismos; proceso para prepararlos; y sus usos para preparar un producto para el tratamiento y/o prevención de infecciones fúngicas en mamíferos, preferentemente en seres humanos. También preparados farmacéuticos que contienen los compuestos. El compuesto puede tener la fórmula (1) o (2) y sus sales, enantiómeros, diastereómeros, óxidos-N, prodrogas o metabolitos farmacéuticamente aceptables, en donde X se selecciona del grupo que consiste de CH2, CO, CS y SO2; Ar es un grupo fenil sustituido que tiene uno a tres sustituyentes independientemente seleccionados de un halógeno, alquil C1-4, grupo alquil halogenado más bajo C1-4 y grupo alcoxi halogenado más bajo C1-4 tales como 2,4-difluorofenil, 2,4-diclorofenil, 4-clorofenil, 4-fluorofenil, 2-clorofenil, 2-fluorofenil, 4-trifluorometilfenil, 2-fluoro-4-clorofenil, 2-cloro-4-fluorofenil, 4-trifluorometoxifenil,2,4,6-trifluorofenil, 4-bromofenil; R1 y R2 son cada uno independientemente seleccionados del grupo que consiste de hidrógeno, alquil C1-4, alcoxi C1-4, amino, hidroxi, nitro, ciano, carboxil, carboxil protegido y SO2R' en donde R' es hidrógeno, alquil o aril; Y es un grupo fenil que no está sustituido o sustituido por 1-3 sustituyentes cada uno independientemente seleccionado del grupo que consiste de halógeno, nitro, amino, ciano, carboxil, carboxil protegido, hidroxi, alquil C1-4, alcoxi C1-4 y SO2R' en donde R' es hidrógeno, alquil o aril; R3 se selecciona del grupo que consiste de hidrógeno, grupo alquil C1-4, alcoxi C1-4, nitro, amino, ciano, carboxil, carboxil protegido y SO2R' en donde R' es hidrógeno, alquil o aril; y X1, X2, Y1, Y2 y Z son independientemente seleccionados del grupo que consiste de hidrógeno, halógeno, nitro, ciano, amino, sulfonilo, aril, alquil C1-4, alcoxi C1-4, grupo alquil halogenado más bajo C1-4, grupo alcoxi halogenado más bajo C1-4 y carboxil, o carboxil protegido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1197DE2000 | 2000-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035525A1 true AR035525A1 (es) | 2004-06-02 |
Family
ID=11097140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010106040A AR035525A1 (es) | 2000-12-26 | 2001-12-26 | Compuestos utiles como agentes antifungicos, composicion farmaceutica, usos de los compuestos y proceso para prepararlos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6710049B2 (es) |
| EP (1) | EP1347758A1 (es) |
| JP (1) | JP2004518667A (es) |
| CN (1) | CN1489465A (es) |
| AR (1) | AR035525A1 (es) |
| BG (1) | BG108032A (es) |
| BR (1) | BR0116570A (es) |
| CA (1) | CA2433259A1 (es) |
| CZ (1) | CZ20032028A3 (es) |
| EA (1) | EA200300725A1 (es) |
| EC (1) | ECSP034673A (es) |
| HU (1) | HUP0400725A2 (es) |
| MA (1) | MA26066A1 (es) |
| MX (1) | MXPA03005899A (es) |
| PL (1) | PL362051A1 (es) |
| SK (1) | SK9522003A3 (es) |
| WO (1) | WO2002051408A1 (es) |
| ZA (1) | ZA200304980B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN191819B (es) * | 2001-07-19 | 2004-01-03 | Ranbaxy Lab Ltd | |
| AU2002328176A1 (en) * | 2002-08-26 | 2004-03-11 | Ranbaxy Laboratories Limited | Azole derivatives as antifungal agents |
| WO2007047394A2 (en) * | 2005-10-13 | 2007-04-26 | Epix Delaware, Inc. | Thiotriazolyl derivatives |
| NZ608729A (en) * | 2010-10-01 | 2014-08-29 | Taisho Pharmaceutical Co Ltd | 1,2,4-triazolone derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB567981A (en) | 1943-03-30 | 1945-03-13 | Malcolm Edward Johnson | Improvements in or relating to control valves for vehicle servo brakes |
| TW218017B (es) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| CA2134417A1 (en) * | 1993-12-22 | 1995-06-23 | Katsumi Itoh | Optically active azole derivatives, their production and use |
| CA2150533A1 (en) | 1994-05-31 | 1995-12-01 | Katsumi Itoh | Production of optically active triazole compounds and their intermediates |
| TW318841B (es) | 1995-02-17 | 1997-11-01 | Takeda Pharm Industry Co Ltd | |
| DE19620407A1 (de) * | 1996-05-21 | 1997-11-27 | Bayer Ag | Thiocyano-triazolyl-Derivate |
| CA2402345A1 (en) | 2000-03-07 | 2001-09-13 | Sudershan K. Arora | Azole compounds as therapeutic agents for fungal infections |
-
2001
- 2001-12-21 US US10/026,235 patent/US6710049B2/en not_active Expired - Fee Related
- 2001-12-21 CA CA002433259A patent/CA2433259A1/en not_active Abandoned
- 2001-12-21 EP EP01272204A patent/EP1347758A1/en not_active Withdrawn
- 2001-12-21 CN CNA018225721A patent/CN1489465A/zh active Pending
- 2001-12-21 HU HU0400725A patent/HUP0400725A2/hu unknown
- 2001-12-21 JP JP2002552553A patent/JP2004518667A/ja active Pending
- 2001-12-21 WO PCT/IB2001/002620 patent/WO2002051408A1/en not_active Application Discontinuation
- 2001-12-21 BR BR0116570-4A patent/BR0116570A/pt not_active Application Discontinuation
- 2001-12-21 PL PL01362051A patent/PL362051A1/xx not_active Application Discontinuation
- 2001-12-21 EA EA200300725A patent/EA200300725A1/ru unknown
- 2001-12-21 MX MXPA03005899A patent/MXPA03005899A/es not_active Application Discontinuation
- 2001-12-21 CZ CZ20032028A patent/CZ20032028A3/cs unknown
- 2001-12-21 SK SK952-2003A patent/SK9522003A3/sk unknown
- 2001-12-26 AR ARP010106040A patent/AR035525A1/es unknown
-
2003
- 2003-06-26 EC EC2003004673A patent/ECSP034673A/es unknown
- 2003-06-26 MA MA27214A patent/MA26066A1/fr unknown
- 2003-06-26 ZA ZA200304980A patent/ZA200304980B/en unknown
- 2003-07-25 BG BG108032A patent/BG108032A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL362051A1 (en) | 2004-10-18 |
| MXPA03005899A (es) | 2004-01-26 |
| BR0116570A (pt) | 2005-04-12 |
| WO2002051408A1 (en) | 2002-07-04 |
| MA26066A1 (fr) | 2004-04-01 |
| BG108032A (bg) | 2004-12-30 |
| CZ20032028A3 (cs) | 2003-11-12 |
| ZA200304980B (en) | 2004-04-28 |
| CN1489465A (zh) | 2004-04-14 |
| EA200300725A1 (ru) | 2004-04-29 |
| US6710049B2 (en) | 2004-03-23 |
| EP1347758A1 (en) | 2003-10-01 |
| US20020119984A1 (en) | 2002-08-29 |
| JP2004518667A (ja) | 2004-06-24 |
| HUP0400725A2 (hu) | 2004-07-28 |
| CA2433259A1 (en) | 2002-07-04 |
| ECSP034673A (es) | 2003-08-29 |
| SK9522003A3 (en) | 2003-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |