YU31303A - Jedinjenja imidazola sa pripojenim arilom ili heteroarilom kao anti-inflamatorni i analgetički agensi - Google Patents

Jedinjenja imidazola sa pripojenim arilom ili heteroarilom kao anti-inflamatorni i analgetički agensi

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Publication number
YU31303A
YU31303A YU31303A YUP31303A YU31303A YU 31303 A YU31303 A YU 31303A YU 31303 A YU31303 A YU 31303A YU P31303 A YUP31303 A YU P31303A YU 31303 A YU31303 A YU 31303A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
membered monocyclic
aromatic ring
optionally containing
heteroatoms selected
Prior art date
Application number
YU31303A
Other languages
English (en)
Inventor
Kazunari Nakao
Yoshiyuki Okumura
Miyako Matsumizu
Naomi Uneo
Yoshinobu Hashizume
Tomoki Kato
Akiyoshi Kawai
Yoriko Miyake
Seiji Nukui
Katsuhiro Shinjyo
Kana Taniguchi
Original Assignee
Pfizer Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Pharmaceuticals Inc. filed Critical Pfizer Pharmaceuticals Inc.
Publication of YU31303A publication Critical patent/YU31303A/sh

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract

Ovaj pronalazak daje jedinjenje formule (I) ili njegove farmaceutski prihvatljive soli, gde se Y1, Y2, Y3 i Y4 nezavisno biraju izmedju N, CH itd.; R1 je H, C1-8 alkil, it.; jeQ1 je 5 - 12-clani monociklicni ili biciklicni aromaticni prsten, koji opciono sadrzi do 4 heteroatoma koji se biraju izmedju O, N i S, itd.; A je 5 - 6-clani monociklicni aromaticni prsten, koji opciono sadrzi do 3 heteroatoma koji se biraju izmedju O, N ili S, itd.; B je C1-6alkilen opciono supstitituisan sa okso grupom itd.; W je NH, O itd.; R2 je H, C1-4alkil itd.; Z je 5 - 12-clani monociklicni ili biciklicni aromaticni prsten, koji opciono sadrzi do 3 heteroatoma koji se biraju izmedju O, N i S, itd.; L je halo, C1-4alkil, itd.; m je 0, 1 ili 2; R3 i R4 se nezavisno biraju izmedju H i C1-4alkil; R5 je H, C1-4alkil, itd.; Q2 je 5 - 12-clani monociklicni ili biciklicni aromaticni prsten, ili triciklicni prsten, koji opciono sadrze do 3 heteroatoma koji se biraju izmedju O, N i S, itd. Ova jedinjenja su korisna pri tretmanu medicinskih stanja posredovanih prostaglandinom, kao sto su bol, groznica ili inflamacija, itd. Ovaj pronalazak daje takodje farmaceutski preparat koji sadrzi gornje jedinjenje.
YU31303A 2000-10-19 2001-10-15 Jedinjenja imidazola sa pripojenim arilom ili heteroarilom kao anti-inflamatorni i analgetički agensi YU31303A (sh)

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