PE20020548A1 - Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos - Google Patents

Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos

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Publication number
PE20020548A1
PE20020548A1 PE2001001031A PE2001001031A PE20020548A1 PE 20020548 A1 PE20020548 A1 PE 20020548A1 PE 2001001031 A PE2001001031 A PE 2001001031A PE 2001001031 A PE2001001031 A PE 2001001031A PE 20020548 A1 PE20020548 A1 PE 20020548A1
Authority
PE
Peru
Prior art keywords
alkyl
dimethyl
ethyl
amino
aryl
Prior art date
Application number
PE2001001031A
Other languages
English (en)
Inventor
Kazunari Nakao
Yoshiyuki Okumura
Naomi UENO
Tomoki Kato
Seiji Nukui
Kana Taniguchi
Yoriko Miyake
Katsuhiro Shinjyo
Akiyoshi Kawai
Yoshinobu Hashizume
Miyako Matsumizu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20020548A1 publication Critical patent/PE20020548A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract

SE REFIERE A COMPUESTOS DE IMIDAZOL CONDENSADO CON ARILO HETEROARILO DE FORMULA I DONDE R1 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, ALQUINILO C2-C8, CICLOALQUILO C3-C7, ALCOXI C1-C8, Q1, PIRROLIDINILO, PIPERIDILO, OXOPIRROLIDINILO, OXOPIPERIDILO, Q1SOm, ALQUILO C1-C4-CONR3; Q1 ES UN ANILLO MONOCICLICO, BICICLICO OPCIONALMENTE SUSTITUIDO CON HALOALQUILO C1-C4; R3 ES H, ALQUILO C1-C4; A ES ANILLO AROMATICO, HETEROAROMATICO; B ES ALQUILENO C1-C6 SUSTITUIDO CON HALO, CICLOALQUILENO C3-C7, ALQUILENO C2-C6; Z ES UN ANILLO AROMATICO MONOCICLICO, BICICLICO DE 5-12 MIEMBROS; R2 ES H, ALQUILO C1-C4, OH, ALCOXI C1-C4; Y1, Y2, Y3, Y4 SON N, CH, CL; L ES HALO, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 3-4-{2-[({[(5-CLORO-1,3-DIMETIL-1H-DIMETIL-1H-PIRAZOL-4-IL)SULFONIL]AMINO}CARBONIL)AMINO]ETIL}FENIL)-2-ETIL-5,7-DIMETIL-3H-IMIDAZO[4,5-b]PIRIDINA; 3-(4-{2-[({[(2,4-DIMETIL-1,3-TIAZOL-5-IL)SULFONIL]AMINO}CARBONIL)AMINO]ETIL}FENIL)-2-ETIL-5,7-DIMETIL-3H-IMIDAZO[4,5-b]-PIRIDINA; ENTRE OTROS. LOS COMPUESTOS SON ANTAGONISTAS EL RECEPTOR DE PROSTAGLANDINA E2 Y PUEDEN SER UTILES PARA EL TRATAMIENTO O ALIVIO DEL DOLOR, INFLAMACION, ARTRITIS
PE2001001031A 2000-10-19 2001-10-17 Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos PE20020548A1 (es)

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