EA200300387A1 - Ингибиторы рецептора ep4 для лечения ревматоидного артрита - Google Patents

Ингибиторы рецептора ep4 для лечения ревматоидного артрита

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Publication number
EA200300387A1
EA200300387A1 EA200300387A EA200300387A EA200300387A1 EA 200300387 A1 EA200300387 A1 EA 200300387A1 EA 200300387 A EA200300387 A EA 200300387A EA 200300387 A EA200300387 A EA 200300387A EA 200300387 A1 EA200300387 A1 EA 200300387A1
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EA
Eurasian Patent Office
Prior art keywords
rheumatoid arthritis
treatment
receptor inhibitors
activity
relates
Prior art date
Application number
EA200300387A
Other languages
English (en)
Inventor
Лоран Одоли
Такако Окумура
Масато Симодзо
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200300387A1 publication Critical patent/EA200300387A1/ru

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract

Данное изобретение относится к способу лечения ревматоидного артрита у млекопитающего, включающему введение средства, которое ингибирует активность (EP4) рецептора EP4 простагландина. Кроме того, изобретение относится к способу идентифицирования средств, которые селективно ингибируют активность EP4 in vivo.Отчет о международном поиске был опубликован 2002.07.25.
EA200300387A 2000-10-19 2001-10-15 Ингибиторы рецептора ep4 для лечения ревматоидного артрита EA200300387A1 (ru)

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PCT/IB2001/001942 WO2002032422A2 (en) 2000-10-19 2001-10-15 Ep4 receptor inhibitors to treat rheumatoid arthritis

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EA200300391A EA005991B1 (ru) 2000-10-19 2001-10-15 Имидазольные соединения, арил или гетероарил конденсированные, в качестве противовоспалительных и анальгетических средств
EA200300387A EA200300387A1 (ru) 2000-10-19 2001-10-15 Ингибиторы рецептора ep4 для лечения ревматоидного артрита

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