DE60025632D1 - Thrombopoietin-mimetika - Google Patents
Thrombopoietin-mimetikaInfo
- Publication number
- DE60025632D1 DE60025632D1 DE60025632T DE60025632T DE60025632D1 DE 60025632 D1 DE60025632 D1 DE 60025632D1 DE 60025632 T DE60025632 T DE 60025632T DE 60025632 T DE60025632 T DE 60025632T DE 60025632 D1 DE60025632 D1 DE 60025632D1
- Authority
- DE
- Germany
- Prior art keywords
- mammal
- invented
- thrombopoietin mimetics
- mimetics
- thrombopoietin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
- C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15335899P | 1999-09-10 | 1999-09-10 | |
US153358P | 1999-09-10 | ||
US20366800P | 2000-05-12 | 2000-05-12 | |
US203668P | 2000-05-12 | ||
PCT/US2000/024665 WO2001017349A1 (en) | 1999-09-10 | 2000-09-08 | Thrombopoietin mimetics |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60025632D1 true DE60025632D1 (de) | 2006-04-06 |
DE60025632T2 DE60025632T2 (de) | 2006-08-10 |
Family
ID=26850465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60025632T Expired - Lifetime DE60025632T2 (de) | 1999-09-10 | 2000-09-08 | Thrombopoietin-mimetika |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1213965B1 (de) |
JP (1) | JP4488663B2 (de) |
AT (1) | ATE315934T1 (de) |
AU (1) | AU770564B2 (de) |
DE (1) | DE60025632T2 (de) |
ES (1) | ES2256038T3 (de) |
WO (1) | WO2001017349A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
US6887890B2 (en) | 2000-05-30 | 2005-05-03 | Chugai Seiyaku Kabushiki Kaisha | Compounds exhibiting thrombopoietin-like activities |
WO2002085343A1 (en) * | 2001-03-01 | 2002-10-31 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
TWI280128B (en) | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
EP1552828A4 (de) | 2002-08-14 | 2007-01-24 | Nissan Chemical Ind Ltd | Thrombopoetin-rezeptor-aktivator und verfahren zu seiner herstellung |
TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
WO2006047344A1 (en) | 2004-10-25 | 2006-05-04 | Ligand Pharmaceuticals, Inc. | Thrombopoietin activity modulating compounds and methods |
CA2588979C (en) | 2004-12-08 | 2013-01-22 | Nissan Chemical Industries, Ltd. | 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators |
RU2401259C2 (ru) | 2004-12-14 | 2010-10-10 | Ниссан Кемикал Индастриз, ЛТД | Амидные соединения и активаторы рецептора тромбопоэтина |
EP1904472A1 (de) | 2005-07-15 | 2008-04-02 | Nissan Chemical Industries, Ltd. | Thiophen-verbindungen und thrombopoietin-rezeptor-aktivatoren |
US7960425B2 (en) | 2005-07-20 | 2011-06-14 | Nissan Chemical Industries, Ltd. | Pyrazole compounds and thrombopoietin receptor activators |
MX2008002063A (es) * | 2005-08-19 | 2008-04-16 | Astrazeneca Ab | Derivados de pirazolona para el tratamiento de tuberculosis. |
JP5205967B2 (ja) | 2005-11-07 | 2013-06-05 | 日産化学工業株式会社 | ヒドラジド化合物及びトロンボポエチンレセプター活性化剤 |
JP2009519352A (ja) * | 2005-11-23 | 2009-05-14 | リガンド・ファーマシューティカルズ・インコーポレイテッド | トロンボポエチン活性調節化合物および方法 |
JP5157900B2 (ja) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
EP2086551A4 (de) * | 2006-12-01 | 2011-06-08 | Stategics Inc | Thrombopoietin-mimetika |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
CN101481352A (zh) | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
US8609693B2 (en) | 2009-05-29 | 2013-12-17 | Glaxosmithkline Llc | Methods of administration of thrombopoietin agonist compounds |
CN101921232A (zh) | 2009-06-11 | 2010-12-22 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用 |
WO2012102937A2 (en) | 2011-01-25 | 2012-08-02 | Irm Llc | Compounds that expand hematopoietic stem cells |
WO2013086436A1 (en) | 2011-12-08 | 2013-06-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
BR112014018524B1 (pt) | 2012-01-27 | 2023-03-28 | Universite De Montreal | Derivados de pirimido [4,5-b]indol, seu usos, composição farmaceutica, e método in vivo ou ex vivo para aumen-tar as células estaminais e/ou progenitoras |
CN103232730B (zh) * | 2013-01-10 | 2015-01-14 | 浙江山峪染料化工有限公司 | 一种混拼型分散黄染料 |
CN103232727B (zh) * | 2013-01-10 | 2014-09-03 | 浙江山峪染料化工有限公司 | 一种多组份拼混型分散黄染料 |
CN103232729A (zh) * | 2013-01-10 | 2013-08-07 | 浙江山峪染料化工有限公司 | 多组份拼混型分散黄染料配方 |
CN103232728B (zh) * | 2013-01-10 | 2014-08-20 | 浙江山峪染料化工有限公司 | 混拼型分散黄染料 |
CN103044968B (zh) * | 2013-01-11 | 2014-10-22 | 浙江山峪染料化工有限公司 | 一种分散黄染料 |
CN111620870B (zh) | 2014-04-22 | 2023-01-03 | 蒙特利尔大学 | 化合物及其在扩增造血干细胞和/或造血祖细胞中的应用 |
WO2016068270A1 (ja) | 2014-10-31 | 2016-05-06 | 日産化学工業株式会社 | リガンド結合繊維及び当該繊維を用いた細胞培養基材 |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5482546A (en) * | 1994-03-30 | 1996-01-09 | Canon Kabushiki Kaisha | Dye, ink containing the same, and ink-jet recording method and instrument using the ink |
GC0000177A (en) * | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
-
2000
- 2000-09-08 ES ES00961674T patent/ES2256038T3/es not_active Expired - Lifetime
- 2000-09-08 WO PCT/US2000/024665 patent/WO2001017349A1/en active IP Right Grant
- 2000-09-08 EP EP00961674A patent/EP1213965B1/de not_active Expired - Lifetime
- 2000-09-08 JP JP2001521152A patent/JP4488663B2/ja not_active Expired - Fee Related
- 2000-09-08 DE DE60025632T patent/DE60025632T2/de not_active Expired - Lifetime
- 2000-09-08 AT AT00961674T patent/ATE315934T1/de not_active IP Right Cessation
- 2000-09-08 AU AU73594/00A patent/AU770564B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU770564B2 (en) | 2004-02-26 |
EP1213965A1 (de) | 2002-06-19 |
EP1213965A4 (de) | 2003-05-02 |
AU7359400A (en) | 2001-04-10 |
ATE315934T1 (de) | 2006-02-15 |
EP1213965B1 (de) | 2006-01-18 |
WO2001017349A1 (en) | 2001-03-15 |
JP2003508463A (ja) | 2003-03-04 |
ES2256038T3 (es) | 2006-07-16 |
DE60025632T2 (de) | 2006-08-10 |
JP4488663B2 (ja) | 2010-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |