ATE350044T1 - Thrombopoietinmimetika - Google Patents

Thrombopoietinmimetika

Info

Publication number
ATE350044T1
ATE350044T1 AT00965329T AT00965329T ATE350044T1 AT E350044 T1 ATE350044 T1 AT E350044T1 AT 00965329 T AT00965329 T AT 00965329T AT 00965329 T AT00965329 T AT 00965329T AT E350044 T1 ATE350044 T1 AT E350044T1
Authority
AT
Austria
Prior art keywords
mammal
invented
thrombopoietin mimetics
mimetics
thrombopoietin
Prior art date
Application number
AT00965329T
Other languages
English (en)
Inventor
Kevin J Duffy
Juan I Luengo
Nannan Liu
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE350044T1 publication Critical patent/ATE350044T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
AT00965329T 1999-09-24 2000-09-22 Thrombopoietinmimetika ATE350044T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15595899P 1999-09-24 1999-09-24

Publications (1)

Publication Number Publication Date
ATE350044T1 true ATE350044T1 (de) 2007-01-15

Family

ID=22557467

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965329T ATE350044T1 (de) 1999-09-24 2000-09-22 Thrombopoietinmimetika

Country Status (8)

Country Link
US (1) US6552008B1 (de)
EP (1) EP1223944B1 (de)
JP (1) JP2003509462A (de)
AT (1) ATE350044T1 (de)
AU (1) AU771460B2 (de)
DE (1) DE60032783T2 (de)
ES (1) ES2279769T3 (de)
WO (1) WO2001021180A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
US6887890B2 (en) 2000-05-30 2005-05-03 Chugai Seiyaku Kabushiki Kaisha Compounds exhibiting thrombopoietin-like activities
AU2002239718A1 (en) * 2000-12-19 2002-07-01 Ligand Pharmaceuticals Thrombopoietin mimetics
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
JP4412173B2 (ja) 2002-08-14 2010-02-10 日産化学工業株式会社 トロンボポエチンレセプター活性化剤ならびにそれらの製造方法
AU2003275077B2 (en) * 2002-09-18 2010-02-04 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
US20090143453A1 (en) * 2003-04-29 2009-06-04 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US20100004302A1 (en) * 2003-04-29 2010-01-07 Connie Erickson-Miller Methods for Treating Degenerative Diseases/Injuries
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
US20090048318A1 (en) * 2003-04-29 2009-02-19 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
WO2004096154A2 (en) * 2003-04-29 2004-11-11 Smithkline Beecham Corporation Methods for treating degenerative diseases/injuries
KR101227666B1 (ko) * 2003-05-12 2013-01-31 아피맥스, 인크. 에리스로포이에틴 수용체에 결합하는 펩티드
CA2525464A1 (en) 2003-05-12 2004-11-25 Qun Yin Novel poly(ethylene glycol) modified compounds and uses thereof
WO2004101606A2 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
EP2204193A3 (de) * 2003-05-12 2010-08-18 Affymax, Inc. Spacer-Bestandteile für Poly(ethylenglykol)-modifizierte Verbindungen auf Peptidbasis
HUE032370T2 (en) 2003-08-28 2017-09-28 Janssen Pharmaceuticals Inc Peptides and compounds that bind to thrombopoietin receptors
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005118551A2 (en) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
BRPI0516883A (pt) 2004-10-25 2008-09-23 Ligand Pharm Inc compostos e métodos para modulação da atividade de trombopoietina
CN101142234A (zh) * 2004-11-11 2008-03-12 阿费麦克斯公司 结合红细胞生成素受体的新肽
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
US7125446B2 (en) * 2004-11-19 2006-10-24 Eastman Kodak Company Yellow dyes for ink jet inks
CA2588979C (en) 2004-12-08 2013-01-22 Nissan Chemical Industries, Ltd. 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators
WO2006064957A1 (ja) 2004-12-14 2006-06-22 Nissan Chemical Industries, Ltd. アミド化合物及びトロンボポエチンレセプター活性化剤
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2007010954A1 (en) 2005-07-15 2007-01-25 Nissan Chemical Industries, Ltd. Thiophene compounds and thrombopoietin receptor activators
JP5104752B2 (ja) 2005-07-20 2012-12-19 日産化学工業株式会社 ピラゾール化合物及びトロンボポエチンレセプター活性化剤
EP1947101A4 (de) 2005-11-07 2009-09-16 Nissan Chemical Ind Ltd Hydrazidverbindung und thrombopoietinrezeptoraktivator
KR20080080305A (ko) * 2005-11-23 2008-09-03 리간드 파마슈티칼스 인코포레이티드 트롬보포이에틴 활성 조절 화합물 및 이의 조절 방법
EP2025671A4 (de) 2006-06-07 2011-04-06 Nissan Chemical Ind Ltd Stickstoffhaltige heterocyclische verbindung und thrombopoietinrezeptoraktivator
US7737149B2 (en) * 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
JP2010520855A (ja) * 2007-01-31 2010-06-17 アフィーマックス・インコーポレイテッド 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
CN102123989A (zh) * 2008-06-19 2011-07-13 阿斯利康(瑞典)有限公司 吡唑化合物436
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
US8680150B2 (en) 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
PT3127427T (pt) 2009-05-29 2020-04-17 Novartis Ag Metódos de administração de compostos agonistas da trombopoietina
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
WO2012102937A2 (en) 2011-01-25 2012-08-02 Irm Llc Compounds that expand hematopoietic stem cells
WO2013086436A1 (en) 2011-12-08 2013-06-13 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
SG11201404241SA (en) 2012-01-27 2014-08-28 Univ Montreal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
US20140179712A1 (en) 2012-12-21 2014-06-26 Astrazeneca Ab Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide
WO2015161373A1 (en) 2014-04-22 2015-10-29 Université de Montréal Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
WO2016068270A1 (ja) 2014-10-31 2016-05-06 日産化学工業株式会社 リガンド結合繊維及び当該繊維を用いた細胞培養基材

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2950273A (en) * 1956-11-20 1960-08-23 Agfa Ag Process for the production of symmetrical and unsymmetrical azo compounds
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
WO2001021180A1 (en) 2001-03-29
AU7606400A (en) 2001-04-24
DE60032783D1 (en) 2007-02-15
DE60032783T2 (de) 2007-12-06
EP1223944B1 (de) 2007-01-03
JP2003509462A (ja) 2003-03-11
US6552008B1 (en) 2003-04-22
EP1223944A1 (de) 2002-07-24
EP1223944A4 (de) 2002-10-30
AU771460B2 (en) 2004-03-25
ES2279769T3 (es) 2007-09-01

Similar Documents

Publication Publication Date Title
ATE350044T1 (de) Thrombopoietinmimetika
DE60025632D1 (de) Thrombopoietin-mimetika
DE60031714D1 (de) Thrombopoietin-mimetika
MY136707A (en) Thrombopoietin mimetics
WO2002049413A3 (en) Thrombopoietin mimetics
WO2004054515A3 (en) Thrombopoietin mimetics
EP1133291A4 (de) Verfahren zur behandlung der thrombozytopenie
CY1108221T1 (el) Μεθοδος για την αναπαραγωγη πλευρομουτιλινων
DE60124684D1 (de) Sulfonamido-substituierte verbrückte bicycloalkylderivative
DE60101265D1 (de) Behandlung von augenschmerzen
ATE203519T1 (de) Chinolinderivate als antimalariamittel
ATE516027T1 (de) Orazamid orotat zur vorbeugung von leberschäden
DE60101559D1 (de) Benutzung von comt-inhibitoren als analgetika
DK1305037T3 (da) Smertestillende medikament
DE60110748D1 (de) Behandlung von fluorkohlenstoff-beschickungen
ATE302008T1 (de) Behandlung von entzündlichen erkrankungen
CY1106363T1 (el) Χρηση του ενepγοποιημενου παραγοντα πηξης vii για την αγωγη των επαγομενων απο θρομβολυτικη θepαπεια μειζονων αιμορραγιων
BR0010699A (pt) Benzimidazóis substituìdos, sua produção e utilização dos mesmos como agente contra protozoários parasitários
EA200100785A1 (ru) Шипучие слабительные средства
NO20005548D0 (no) Mykobakterieinhibitorer
DE60125035D1 (de) Behandlung von plasmid-haltigen lösungen
LU91009B1 (de) Behandlung von Verbrennungen
ATE294590T1 (de) Verwendung von interleukin-11 zur behandlung von hämoragischem schock
UA35854A (uk) Спосіб лікування приховано протікаючого силікотуберкульозу

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties