EA200400734A1 - Способ и композиция для потенциирования действия опиатного анальгетика - Google Patents

Способ и композиция для потенциирования действия опиатного анальгетика

Info

Publication number
EA200400734A1
EA200400734A1 EA200400734A EA200400734A EA200400734A1 EA 200400734 A1 EA200400734 A1 EA 200400734A1 EA 200400734 A EA200400734 A EA 200400734A EA 200400734 A EA200400734 A EA 200400734A EA 200400734 A1 EA200400734 A1 EA 200400734A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition
opiative
potentiating
analgetic action
treating pain
Prior art date
Application number
EA200400734A
Other languages
English (en)
Inventor
Анил Гулати
Original Assignee
Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс filed Critical Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс
Publication of EA200400734A1 publication Critical patent/EA200400734A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Раскрываются композиция и способы лечения боли и подавления или реверсирования толерантности к опиатным анальгетикам. В композиции и способе используются опиатный анальгетик и антагонист эндотелина в качестве активных агентов для лечения боли у млекопитающих, включая людей.Отчет о международном поиске был опубликован 2003.09.25.
EA200400734A 2001-11-27 2002-11-22 Способ и композиция для потенциирования действия опиатного анальгетика EA200400734A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33359901P 2001-11-27 2001-11-27
PCT/US2002/037461 WO2003045434A2 (en) 2001-11-27 2002-11-22 Endothelin antagonists ina method and composition for potentiating an opiate analgesic

Publications (1)

Publication Number Publication Date
EA200400734A1 true EA200400734A1 (ru) 2004-12-30

Family

ID=23303472

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400734A EA200400734A1 (ru) 2001-11-27 2002-11-22 Способ и композиция для потенциирования действия опиатного анальгетика

Country Status (14)

Country Link
US (3) US7973064B2 (ru)
EP (1) EP1448233A2 (ru)
JP (1) JP2005513033A (ru)
CN (1) CN1646166A (ru)
AU (1) AU2002348224A1 (ru)
BR (1) BR0214481A (ru)
CA (1) CA2464768C (ru)
CO (1) CO5590940A2 (ru)
EA (1) EA200400734A1 (ru)
EC (1) ECSP045153A (ru)
MX (1) MXPA04005003A (ru)
NO (1) NO20042612L (ru)
WO (1) WO2003045434A2 (ru)
ZA (1) ZA200403162B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070300258A1 (en) * 2001-01-29 2007-12-27 O'connor Daniel Methods and systems for providing media assets over a network
DK1395289T3 (da) * 2001-06-07 2011-03-28 Christine Dr Sang Behandling af neuropatisk smerte med en N-methyl-D-aspartat- (NMDA-)receptorantagonist
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
ES2384208T3 (es) 2001-11-01 2012-07-02 Spectrum Pharmaceuticals, Inc. Composiciones medicinales para el tratatamiento intravesical del cáncer de vejiga.
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
US7351692B2 (en) * 2002-06-19 2008-04-01 The Board Of Trustees Of The University Of Illinois Method and composition for potentiating the antipyretic action of a nonopioid analgesic
GB0219660D0 (en) 2002-08-23 2002-10-02 Astrazeneca Ab Therapeutic use
US20040138121A1 (en) 2002-10-24 2004-07-15 Anil Gulati Method and composition for preventing and treating solid tumors
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
US20090221490A1 (en) * 2005-09-09 2009-09-03 Anil Gulati Endothelin Receptors In Morphine Withdrawal
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CN101534852B (zh) 2006-08-31 2013-02-13 光谱医药公司 通过施用内皮素激动剂使得肿瘤细胞对放疗敏化
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
WO2009015917A2 (en) * 2007-05-14 2009-02-05 F. Hoffmann-La Roche Ag Dihydroquinone and dihydronaphthridine inhibitors of jnk
US20090143426A1 (en) * 2007-12-04 2009-06-04 Ralph Anthony Stephani Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
PL2424529T3 (pl) * 2009-04-30 2017-06-30 Midwestern University Nowe postępowania terapeutyczne z zastosowaniem centakwiny
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma
ES2825101T3 (es) 2013-07-08 2021-05-14 Univ Midwestern Composiciones y métodos para el tratamiento de trastornos neuropsiquiátricos usando un agonista del receptor de la endotelina B
CN112569238A (zh) * 2019-09-30 2021-03-30 武汉大学 伊马替尼及其衍生物与镇痛药联合用药或复方制剂在治疗疼痛中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
JPH08139146A (ja) 1994-11-14 1996-05-31 Shin Etsu Handotai Co Ltd 半導体表面のライフタイム評価方法
MX9703988A (es) 1994-12-12 1998-02-28 Omeros Med Sys Inc SOLUCIaN Y MÉTODO DE IRRIGACIaN PARA LA INHIBICIaN DEL DOLOR, LA INFLAMACIaN Y ES ESPASMO.
US6673832B1 (en) * 1998-05-04 2004-01-06 Gudarz Davar Methods for identifying compounds for treating pain
CA2409927A1 (en) 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
AU2002241736A1 (en) * 2000-12-21 2002-07-01 Bristol-Myers Squibb Company Method for preventing or treating pain by administering an endothelin antagonist
US20030232787A1 (en) * 2001-05-08 2003-12-18 Dooley David James Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic

Also Published As

Publication number Publication date
US7973064B2 (en) 2011-07-05
EP1448233A2 (en) 2004-08-25
CA2464768C (en) 2009-12-29
CA2464768A1 (en) 2003-06-05
MXPA04005003A (es) 2004-08-11
US20100311665A1 (en) 2010-12-09
US20030100507A1 (en) 2003-05-29
ZA200403162B (en) 2005-01-26
CO5590940A2 (es) 2005-12-30
JP2005513033A (ja) 2005-05-12
BR0214481A (pt) 2004-09-14
NO20042612L (no) 2004-06-22
WO2003045434A3 (en) 2003-09-25
WO2003045434A2 (en) 2003-06-05
US8114896B2 (en) 2012-02-14
US20100113396A1 (en) 2010-05-06
CN1646166A (zh) 2005-07-27
AU2002348224A1 (en) 2003-06-10
ECSP045153A (es) 2004-08-27
US8410148B2 (en) 2013-04-02

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