MXPA04005003A - Antagonistas de endotelina en un metodo y composicion para potenciar un analgesico opiaceo. - Google Patents

Antagonistas de endotelina en un metodo y composicion para potenciar un analgesico opiaceo.

Info

Publication number
MXPA04005003A
MXPA04005003A MXPA04005003A MXPA04005003A MXPA04005003A MX PA04005003 A MXPA04005003 A MX PA04005003A MX PA04005003 A MXPA04005003 A MX PA04005003A MX PA04005003 A MXPA04005003 A MX PA04005003A MX PA04005003 A MXPA04005003 A MX PA04005003A
Authority
MX
Mexico
Prior art keywords
composition
potentiating
endothelin antagonists
opiate analgesic
ina method
Prior art date
Application number
MXPA04005003A
Other languages
English (en)
Inventor
Anil Gulati
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of MXPA04005003A publication Critical patent/MXPA04005003A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe una composicion y metodos para tratarel dolor y para reducir o revertir la tolerancia a los analgesicos. La composicion y metodo utilizan un analgesico opiaceo y un antagonista de endotelina como agentes activos para tratar el dolor en mamiferos, incluyendo humanos.
MXPA04005003A 2001-11-27 2002-11-22 Antagonistas de endotelina en un metodo y composicion para potenciar un analgesico opiaceo. MXPA04005003A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33359901P 2001-11-27 2001-11-27
PCT/US2002/037461 WO2003045434A2 (en) 2001-11-27 2002-11-22 Endothelin antagonists ina method and composition for potentiating an opiate analgesic

Publications (1)

Publication Number Publication Date
MXPA04005003A true MXPA04005003A (es) 2004-08-11

Family

ID=23303472

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005003A MXPA04005003A (es) 2001-11-27 2002-11-22 Antagonistas de endotelina en un metodo y composicion para potenciar un analgesico opiaceo.

Country Status (14)

Country Link
US (3) US7973064B2 (es)
EP (1) EP1448233A2 (es)
JP (1) JP2005513033A (es)
CN (1) CN1646166A (es)
AU (1) AU2002348224A1 (es)
BR (1) BR0214481A (es)
CA (1) CA2464768C (es)
CO (1) CO5590940A2 (es)
EA (1) EA200400734A1 (es)
EC (1) ECSP045153A (es)
MX (1) MXPA04005003A (es)
NO (1) NO20042612L (es)
WO (1) WO2003045434A2 (es)
ZA (1) ZA200403162B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569238A (zh) * 2019-09-30 2021-03-30 武汉大学 伊马替尼及其衍生物与镇痛药联合用药或复方制剂在治疗疼痛中的应用

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070300258A1 (en) * 2001-01-29 2007-12-27 O'connor Daniel Methods and systems for providing media assets over a network
DE60143671D1 (de) * 2001-06-07 2011-01-27 Sang Christine Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
TWI232102B (en) * 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
AU2002350115A1 (en) 2001-11-01 2003-05-12 Spectrum Pharmaceuticals, Inc. Medical compositions for intravesical treatment of bladder cancer
US7351692B2 (en) 2002-06-19 2008-04-01 The Board Of Trustees Of The University Of Illinois Method and composition for potentiating the antipyretic action of a nonopioid analgesic
GB0219660D0 (en) 2002-08-23 2002-10-02 Astrazeneca Ab Therapeutic use
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
JP2006508086A (ja) 2002-10-24 2006-03-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 固形腫瘍を予防および治療するための方法および組成物
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
WO2007030770A2 (en) * 2005-09-09 2007-03-15 Chicago Labs, Inc. Endothelin receptors in morphine withdrawal
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
MX2009002308A (es) 2006-08-31 2009-09-07 Spectrum Pharmaceuticals Inc Sensibilizacion de celulas tumorales a una terapia con radiacion mediante la administracion de agonistas de endotelina.
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
WO2009015917A2 (en) * 2007-05-14 2009-02-05 F. Hoffmann-La Roche Ag Dihydroquinone and dihydronaphthridine inhibitors of jnk
US20090143426A1 (en) * 2007-12-04 2009-06-04 Ralph Anthony Stephani Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
CN102458399B (zh) * 2009-04-30 2014-04-23 美国中西部大学 centhaquin的新制药用途
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma
BR112016000431A8 (pt) 2013-07-08 2018-01-23 Univ Midwestern composições e métodos para o tratamento de distúrbios neuropsiquiátricos usando um agonista do receptor de endotelina-b

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
JPH08139146A (ja) 1994-11-14 1996-05-31 Shin Etsu Handotai Co Ltd 半導体表面のライフタイム評価方法
EP0799051B1 (en) 1994-12-12 2005-07-27 Omeros Corporation Irrigation solution and use thereof for perioperatively inhibiting pain, inflammation and spasm at a wound
US6673832B1 (en) * 1998-05-04 2004-01-06 Gudarz Davar Methods for identifying compounds for treating pain
EP1289558A2 (en) 2000-05-31 2003-03-12 Warner-Lambert Company Llc Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
US6573285B2 (en) 2000-12-21 2003-06-03 Bristol-Myers Squibb Co. Method for preventing or treating pain by administering an endothelin antagonist
US20030232787A1 (en) * 2001-05-08 2003-12-18 Dooley David James Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569238A (zh) * 2019-09-30 2021-03-30 武汉大学 伊马替尼及其衍生物与镇痛药联合用药或复方制剂在治疗疼痛中的应用

Also Published As

Publication number Publication date
US20100311665A1 (en) 2010-12-09
EA200400734A1 (ru) 2004-12-30
US20100113396A1 (en) 2010-05-06
WO2003045434A3 (en) 2003-09-25
ECSP045153A (es) 2004-08-27
EP1448233A2 (en) 2004-08-25
CO5590940A2 (es) 2005-12-30
ZA200403162B (en) 2005-01-26
CA2464768A1 (en) 2003-06-05
US20030100507A1 (en) 2003-05-29
WO2003045434A2 (en) 2003-06-05
NO20042612L (no) 2004-06-22
JP2005513033A (ja) 2005-05-12
AU2002348224A1 (en) 2003-06-10
US8410148B2 (en) 2013-04-02
US8114896B2 (en) 2012-02-14
US7973064B2 (en) 2011-07-05
CA2464768C (en) 2009-12-29
BR0214481A (pt) 2004-09-14
CN1646166A (zh) 2005-07-27

Similar Documents

Publication Publication Date Title
MXPA04005003A (es) Antagonistas de endotelina en un metodo y composicion para potenciar un analgesico opiaceo.
MXPA05010819A (es) Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable.
IL267381A (en) A pharmaceutical preparation containing dextromethorphan and quinidine for the treatment of nervous disorders
HK1064614A1 (en) Use of methylnaltrexone to treat immune suppression
WO2001015678A3 (en) Topical use of kappa opioid agonists to treat otic pain
WO2005107726A3 (en) Method for the treatment of back pain
WO2004030627A3 (en) Synergistic methods and compositions for treating cancer
WO2002005791A3 (en) Antitumor combination comprising an aromatase inhibitor and an egfr antagonist or inhibitor
PT1420801E (pt) Utilização de fucanos no tratamento de adesões, artrite e psoríase
WO2005000215A3 (en) Methods for treating pain
AU2207000A (en) Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia
WO2004037235A3 (en) Method and composition for preventing and treating solid tumors
MY169308A (en) Treatment of tnf? related disorders
EP1539234A4 (en) METHODS OF PREVENTING OR TREATING CELLULAR MALIGNITES BY ADMINISTERING CD2 ANTAGONISTS
BRPI0509420A (pt) método de redução ou inibição da angiogênese e método de aumento da eficácia de tratamento com agente antiangiogênico
WO2004091540A3 (en) Methods of treating pain and compositions for use therefor
AU2002241736A1 (en) Method for preventing or treating pain by administering an endothelin antagonist
WO2004071413A3 (en) Method and composition for potentiating an opiate analgesic
EP1178796A4 (en) AMINOIMIDAZOLE CARBOXAMIDE SALTS USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASE
WO2001007028A3 (en) The use of retinoid receptor antagonists in the treatment of prostate carcinoma
MXPA03011270A (es) Uso de antagonistas rank para tratar cancer.
HK1029944A1 (en) Treatment of follicular lymphomas using inhibitors of the lymphotoxin (lt) pathway
WO2002039996A3 (en) Combined therapy against tumors comprising estramustine phosphate and lhrh agonists or antagonists
BR0111785A (pt) Composições e métodos para tratamento de candidìase
ATE473001T1 (de) Suchtpraevention in der schmerzbehandlung mit gamma vinyl gaba

Legal Events

Date Code Title Description
FA Abandonment or withdrawal