BR0309200A - Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6 - Google Patents
Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6Info
- Publication number
- BR0309200A BR0309200A BR0309200-3A BR0309200A BR0309200A BR 0309200 A BR0309200 A BR 0309200A BR 0309200 A BR0309200 A BR 0309200A BR 0309200 A BR0309200 A BR 0309200A
- Authority
- BR
- Brazil
- Prior art keywords
- diseases involved
- receptor ligands
- treat diseases
- whole blood
- receptor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"USO DE LIGANDOS RECEPTORES EP4 NO TRATAMENTO DE DOENçAS ENVOLVIDAS COM A IL-6". A presente invenção diz respeito ao uso de um ligando receptor EP4 na fabricação de um medicamento para o tratamento de doenças envolvidas com a IL-6. Também diz respeito à análise que compreende: cultivo do sangue total periférico com um composto de teste; e determinação do efeito do composto sobre a ativação das células sang³íneas totais induzida pela PGE2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37236402P | 2002-04-12 | 2002-04-12 | |
PCT/IB2003/001310 WO2003086371A2 (en) | 2002-04-12 | 2003-04-03 | Use of ep4 receptor ligands in the treatment of il-6 involved diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0309200A true BR0309200A (pt) | 2005-02-22 |
Family
ID=29250846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0309200-3A BR0309200A (pt) | 2002-04-12 | 2003-04-03 | Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6 |
Country Status (19)
Country | Link |
---|---|
US (2) | US7148234B2 (pt) |
EP (1) | EP1499305A2 (pt) |
JP (1) | JP2005533756A (pt) |
KR (1) | KR100592007B1 (pt) |
CN (2) | CN100579518C (pt) |
AU (1) | AU2003214525B2 (pt) |
BR (1) | BR0309200A (pt) |
CA (1) | CA2481535C (pt) |
HK (1) | HK1076737A1 (pt) |
IL (1) | IL164263A0 (pt) |
MX (1) | MXPA04009243A (pt) |
MY (1) | MY140867A (pt) |
NO (1) | NO20044462L (pt) |
NZ (1) | NZ535748A (pt) |
PL (1) | PL373246A1 (pt) |
RU (1) | RU2285527C2 (pt) |
TW (1) | TW200409636A (pt) |
WO (1) | WO2003086371A2 (pt) |
ZA (1) | ZA200407795B (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017121B2 (en) * | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
CZ298325B6 (cs) * | 1994-10-21 | 2007-08-29 | Kishimoto@Tadamitsu | Farmaceutický prípravek pro prevenci nebo lécení plasmocytosy |
US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
CZ297083B6 (cs) * | 1998-03-17 | 2006-09-13 | Chugai Seiyaku Kabushiki Kaisha | Cinidlo pro prevenci a lécbu zánetlivého onemocnení streva obsahující aktivní slozku antagonistu IL-6 |
WO2002036165A1 (fr) * | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang |
UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
CN101812021B (zh) * | 2003-03-13 | 2012-12-26 | 出光兴产株式会社 | 含氮杂环衍生物及使用该衍生物的有机电致发光元件 |
US7271271B2 (en) * | 2004-06-28 | 2007-09-18 | Amgen Sf, Llc | Imidazolo-related compounds, compositions and methods for their use |
WO2006095268A1 (en) * | 2005-03-11 | 2006-09-14 | Pfizer Japan Inc. | Crystal forms of an imidazole derivative |
UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
CL2007002994A1 (es) * | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
NZ577109A (en) | 2006-12-15 | 2011-12-22 | Glaxo Group Ltd | Benzamide derivatives as ep4 receptor agonists |
US7977371B2 (en) | 2007-02-26 | 2011-07-12 | Santen Pharmaceutical Co., Ltd. | Pyrrole derivative having ureido group and aminocarbonyl group as substituents |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
US20100305098A1 (en) * | 2007-11-15 | 2010-12-02 | Qian Chen | Methods of use |
CA2724077C (en) * | 2008-05-14 | 2016-04-26 | Astellas Pharma Inc. | Amide compound |
JP5492496B2 (ja) | 2008-08-25 | 2014-05-14 | 参天製薬株式会社 | ウレイド基、アミノカルボニル基及び置換基を有してもよい二環式基を置換基として有する新規ピロール誘導体 |
MX2012000322A (es) | 2009-07-17 | 2012-02-08 | Novozymes As | Metodo de analisis del decaimiento de la celulosa en la hidrolisis del material celulosico. |
JP2013508282A (ja) | 2009-10-14 | 2013-03-07 | ジェンムス ファーマ インコーポレイティド | ウイルス感染のための併用療法処置 |
KR101552760B1 (ko) * | 2009-12-18 | 2015-09-11 | 미쓰비시 타나베 파마 코퍼레이션 | 신규 항혈소판약 |
EP2529022A1 (en) | 2010-01-29 | 2012-12-05 | Novozymes A/S | Biogas production process with enzymatic pre-treatment |
CA2789665C (en) | 2010-02-22 | 2020-06-16 | Raqualia Pharma Inc. | Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases |
WO2011123505A1 (en) | 2010-03-30 | 2011-10-06 | Novozymes North America, Inc. | Processes of producing a fermentation product |
EP2601301A1 (en) | 2010-08-02 | 2013-06-12 | Novozymes North America, Inc. | Process of producing a fermentation product |
EP2621885B1 (en) * | 2010-09-29 | 2014-10-29 | The Procter and Gamble Company | Methods of synthesizing 2-methoxymethyl-1,4-benzenediamine |
BR112013012357A2 (pt) | 2010-11-19 | 2016-10-11 | Novozymes North America Inc | processos de produzir um produto de fermentação, de produzir um açúcar, de produzir uma dextrina e de produzir sacarose, e, composição |
JP5986566B2 (ja) | 2011-07-07 | 2016-09-06 | イハラケミカル工業株式会社 | ニトロベンゼン化合物の製造方法 |
PL2792667T3 (pl) | 2011-12-14 | 2018-05-30 | Kumiai Chemical Industry Co., Ltd. | Związek difenyloaminowy i sposób jego wytwarzania |
UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
WO2014208296A1 (ja) | 2013-06-25 | 2014-12-31 | イハラケミカル工業株式会社 | ニトロベンゼン化合物を製造する方法 |
CA2920856A1 (en) | 2013-08-09 | 2015-02-12 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
TW201607943A (zh) | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ep4配體之新穎苯并咪唑衍生物 |
MX2016011025A (es) | 2014-03-06 | 2016-11-29 | Aratana Therapeutics Inc | Composiciones de grapiprant y metodos para usar las mismas. |
WO2015143144A1 (en) | 2014-03-19 | 2015-09-24 | Novozymes A/S | Method for enhancing activity of an x143 polypeptide |
US9343949B2 (en) * | 2014-09-22 | 2016-05-17 | Texas Instruments Incorporated | Control circuit to detect a noise signal during a state change of a switch |
EP3072943B1 (en) | 2015-03-26 | 2018-05-02 | Idemitsu Kosan Co., Ltd. | Dibenzofuran/carbazole-substituted benzonitriles |
JP6789526B2 (ja) | 2016-05-09 | 2020-11-25 | クミアイ化学工業株式会社 | ニトロベンゼン化合物を製造する方法 |
WO2017207340A1 (de) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Neue substituierte benzimidazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
MX2021009378A (es) * | 2016-06-30 | 2022-06-29 | Daewoong Pharmaceutical Co Ltd | Derivados de pirazolopirimidina como inhibidor de cinasa. |
WO2018162562A1 (en) | 2017-03-10 | 2018-09-13 | Bayer Pharma Aktiengesellschaft | Use of an ep4 antagonist for the treatment of inflammatory pain |
WO2019038156A1 (en) | 2017-08-22 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | USE OF AN EP4 ANTAGONIST FOR THE TREATMENT OF ARTHRITIS |
US10239885B1 (en) | 2018-06-18 | 2019-03-26 | Avista Pharma Solutions, Inc. | Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist |
US20210315909A1 (en) * | 2018-07-11 | 2021-10-14 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
EP4364798A2 (en) | 2018-10-05 | 2024-05-08 | Annapurna Bio Inc. | Compounds and compositions for treating conditions associated with apj receptor activity |
WO2020160075A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Chemical compounds |
WO2020160074A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Synthetic process and novel intermediates |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4536507A (en) * | 1977-07-26 | 1985-08-20 | Merck & Co., Inc. | Prostaglandin antagonists |
TW401408B (en) * | 1995-07-21 | 2000-08-11 | Fujisawa Pharmaceutical Co | Heterocyclic compounds having prostaglandin I2 agonism |
AUPP608898A0 (en) * | 1998-09-23 | 1998-10-15 | Fujisawa Pharmaceutical Co., Ltd. | New use of prostaglandin E2 antagonists |
US6437146B1 (en) * | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
HN2001000224A (es) * | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
GB0031295D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
-
2003
- 2003-04-03 RU RU2004130320/15A patent/RU2285527C2/ru not_active IP Right Cessation
- 2003-04-03 AU AU2003214525A patent/AU2003214525B2/en not_active Ceased
- 2003-04-03 PL PL03373246A patent/PL373246A1/xx not_active Application Discontinuation
- 2003-04-03 WO PCT/IB2003/001310 patent/WO2003086371A2/en active IP Right Grant
- 2003-04-03 MX MXPA04009243A patent/MXPA04009243A/es active IP Right Grant
- 2003-04-03 CA CA2481535A patent/CA2481535C/en not_active Expired - Fee Related
- 2003-04-03 NZ NZ535748A patent/NZ535748A/en not_active IP Right Cessation
- 2003-04-03 KR KR1020047016248A patent/KR100592007B1/ko not_active IP Right Cessation
- 2003-04-03 BR BR0309200-3A patent/BR0309200A/pt not_active IP Right Cessation
- 2003-04-03 JP JP2003583392A patent/JP2005533756A/ja not_active Ceased
- 2003-04-03 EP EP03710104A patent/EP1499305A2/en not_active Withdrawn
- 2003-04-03 CN CN03813401A patent/CN100579518C/zh not_active Expired - Fee Related
- 2003-04-03 IL IL16426303A patent/IL164263A0/xx unknown
- 2003-04-03 CN CNA2007100849371A patent/CN101023946A/zh active Pending
- 2003-04-07 TW TW092107895A patent/TW200409636A/zh unknown
- 2003-04-09 MY MYPI20031318A patent/MY140867A/en unknown
- 2003-04-10 US US10/411,491 patent/US7148234B2/en not_active Expired - Fee Related
-
2004
- 2004-09-28 ZA ZA200407795A patent/ZA200407795B/xx unknown
- 2004-10-20 NO NO20044462A patent/NO20044462L/no not_active Application Discontinuation
-
2005
- 2005-10-06 HK HK05108862.3A patent/HK1076737A1/xx not_active IP Right Cessation
-
2006
- 2006-11-03 US US11/556,414 patent/US7928119B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HK1076737A1 (en) | 2006-01-27 |
CN101023946A (zh) | 2007-08-29 |
PL373246A1 (en) | 2005-08-22 |
US7928119B2 (en) | 2011-04-19 |
AU2003214525B2 (en) | 2008-09-25 |
RU2285527C2 (ru) | 2006-10-20 |
CA2481535A1 (en) | 2003-10-23 |
ZA200407795B (en) | 2007-01-31 |
KR20040105864A (ko) | 2004-12-16 |
US20070066618A1 (en) | 2007-03-22 |
RU2004130320A (ru) | 2005-06-10 |
CA2481535C (en) | 2010-08-17 |
US20030236260A1 (en) | 2003-12-25 |
NZ535748A (en) | 2007-06-29 |
MXPA04009243A (es) | 2005-06-08 |
MY140867A (en) | 2010-01-29 |
JP2005533756A (ja) | 2005-11-10 |
AU2003214525A1 (en) | 2003-10-27 |
US7148234B2 (en) | 2006-12-12 |
TW200409636A (en) | 2004-06-16 |
NO20044462L (no) | 2005-01-11 |
WO2003086371A2 (en) | 2003-10-23 |
WO2003086371A3 (en) | 2004-06-03 |
KR100592007B1 (ko) | 2006-06-21 |
CN1658847A (zh) | 2005-08-24 |
EP1499305A2 (en) | 2005-01-26 |
CN100579518C (zh) | 2010-01-13 |
IL164263A0 (en) | 2005-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0309200A (pt) | Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6 | |
Zochodne | Diabetes mellitus and the peripheral nervous system: manifestations and mechanisms | |
Halonen et al. | Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat | |
Quéreux et al. | Photodynamic therapy with methyl-aminolevulinic acid for paucilesional mycosis fungoides: a prospective open study and review of the literature | |
BR0308928A (pt) | Uso de toxina botulìnica para o tratamento de doenças cardiovasculares, bem como composição para uso em um procedimento cardiovascular | |
Hajós-Korcsok et al. | Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine | |
BR9914648A (pt) | Processo para monitorar ação medicamentosa deinibidor de proteasoma | |
CY1110889T1 (el) | C-αρυλο γλυκοζιτικοι sglt2 αναστολεις και μεθοδος για την παραγωγη τους | |
Yang et al. | Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release | |
TR200101673A2 (tr) | Düz kas hücrelerinin sıkışmasıyla ilgili hastalıkların tedavisindeki kompozisyonlar için biyokimyasal maddeler. | |
WO2004097429A3 (en) | Apociii and the treatmentand diagnosis of diabetes | |
RU2008116567A (ru) | Биомаркеры | |
Woods | Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity | |
EP1744162A4 (en) | Cancer diagnosis and treatment using an anti-ROBO1 antibody | |
Zhuang et al. | Tranilast directly targets NLRP3 to protect melanocytes from keratinocyte-derived IL-1β under oxidative stress | |
Alagic et al. | Protection against acoustic trauma by direct application of D-methionine to the inner ear | |
Nash et al. | Morphine-induced modulation of endolysosomal iron mediates upregulation of ferritin heavy chain in cortical neurons | |
Pinto et al. | Burning mouth syndrome | |
RU2007103332A (ru) | Способы лечения опосредуемых ccr2 заболеваний или нарушений | |
JP2008508253A5 (pt) | ||
Lee et al. | Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia | |
Leite et al. | Adverse hypersensitivity reactions in orthodontics | |
De Sanctis et al. | Treatment of venous ulcers with pentoxifylline: a 12-month, double-blind, placebo controlled trial. Microcirculation and healing | |
Castellon et al. | Neuropsychological studies in breast cancer: in search of chemobrain | |
Kundrotienė et al. | Fluoro-Jade and TUNEL staining as useful tools to identify ischemic brain damage following moderate extradural compression of sensorimotor cortex |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012. |