ATE349446T1 - Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel - Google Patents
Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittelInfo
- Publication number
- ATE349446T1 ATE349446T1 AT02728893T AT02728893T ATE349446T1 AT E349446 T1 ATE349446 T1 AT E349446T1 AT 02728893 T AT02728893 T AT 02728893T AT 02728893 T AT02728893 T AT 02728893T AT E349446 T1 ATE349446 T1 AT E349446T1
- Authority
- AT
- Austria
- Prior art keywords
- diagnostic imaging
- imaging agents
- amyloid plaque
- aggregation inhibitors
- plaque aggregation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28528201P | 2001-04-23 | 2001-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE349446T1 true ATE349446T1 (de) | 2007-01-15 |
Family
ID=23093574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02728893T ATE349446T1 (de) | 2001-04-23 | 2002-04-23 | Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel |
Country Status (12)
Country | Link |
---|---|
US (5) | US6696039B2 (de) |
EP (1) | EP1381604B1 (de) |
JP (1) | JP4317955B2 (de) |
KR (1) | KR20040058111A (de) |
CN (1) | CN100422180C (de) |
AT (1) | ATE349446T1 (de) |
AU (1) | AU2002258915B2 (de) |
CA (1) | CA2444214A1 (de) |
DE (1) | DE60217090T2 (de) |
ES (1) | ES2274973T3 (de) |
TW (1) | TWI245764B (de) |
WO (1) | WO2002085903A2 (de) |
Families Citing this family (99)
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US7544511B2 (en) * | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
GB0018473D0 (en) * | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
HU230375B1 (hu) | 2000-08-24 | 2016-03-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
CN100422180C (zh) * | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
CA2474411A1 (en) * | 2002-02-13 | 2003-08-21 | Amersham Plc | Benzothiazole derivatives for in vivo imaging of amyloid plaques |
US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
WO2004053071A2 (en) * | 2002-12-09 | 2004-06-24 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
US20040204344A1 (en) * | 2003-01-22 | 2004-10-14 | Xudong Huang | Amyloid-binding, metal-chelating agents |
AU2004221897B2 (en) * | 2003-03-14 | 2010-11-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Benzothiazole derivative compounds, compositions and uses |
CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
EP1631561B1 (de) | 2003-05-07 | 2010-08-18 | General Electric Company | Zusammensetzungen und verfahren zur in vivo abbildung von loeslichen beta-amyloid |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
US20050049487A1 (en) * | 2003-08-26 | 2005-03-03 | Johnson Bruce Fletcher | Compounds and kits for preparing imaging agents and methods of imaging |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
EP1732864B1 (de) * | 2004-03-18 | 2013-12-25 | Suntory Holdings Limited | Radioaktiv markiertes 3-[3-(benzoylamido)benzyloxy]asparaginsäurederivat und verfahren zu dessen herstellung |
CA2587248C (en) * | 2004-07-02 | 2014-01-07 | William E. Klunk | Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies |
EP1768709A1 (de) * | 2004-07-02 | 2007-04-04 | University of Pittsburgh | Verfahren zur diagnose von prodromalen formen von erkrankungen im zusammenhang mit amyloid-ablagerung |
WO2006026184A2 (en) * | 2004-08-20 | 2006-03-09 | Washington University | Blood brain barrier permeation peptides |
KR101505347B1 (ko) | 2004-11-17 | 2015-03-23 | 뉴럴스템, 인크. | 신경퇴행성 증상의 치료를 위한 인간 신경 세포의 이식 |
EP1893245A4 (de) * | 2005-06-24 | 2009-06-24 | Univ Pennsylvania | Radioaktiv markierte pegylierung von liganden zur verwendung als kontrastmittel |
WO2007011834A2 (en) * | 2005-07-15 | 2007-01-25 | The Regents Of The University Of California | Compounds and method for the diagnosis and treatment of amyloid associated diseases |
EP1928237A4 (de) | 2005-09-02 | 2011-03-09 | Abbott Lab | Neue heterocyclen auf imidazo-basis |
WO2007033080A2 (en) * | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
ATE533485T1 (de) † | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
EP1956013B1 (de) | 2005-11-30 | 2016-04-13 | Fujifilm RI Pharma Co., Ltd. | Diagnostikum und heilmittel für eine durch amyloidaggregation und/oder ablagerung verursachte krankheit |
WO2007069565A1 (ja) * | 2005-12-12 | 2007-06-21 | Ono Pharmaceutical Co., Ltd. | 二環式複素環化合物 |
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AU2017423862A1 (en) | 2017-07-20 | 2020-02-06 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and ibuprofen |
JP6831802B2 (ja) * | 2018-01-12 | 2021-02-17 | 上海富吉医療器械有限公司Shanghai Chartwell Medical Instrument Co., Ltd. | 放射性核種標識化合物及びこれを含有するイメージング剤 |
WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
KR102240400B1 (ko) * | 2020-11-19 | 2021-04-15 | 한국원자력연구원 | 베타-아밀로이드 검출용 수용성 화합물 |
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GB9317949D0 (en) | 1993-08-28 | 1993-10-13 | Stevens Malcolm F G | Benzothiazole compounds |
US5552415A (en) | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
US6417178B1 (en) | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US6054114A (en) * | 1996-05-08 | 2000-04-25 | Massachusetts Institute Of Technology | Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro |
WO1998017267A1 (en) | 1996-10-23 | 1998-04-30 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
US5869500A (en) | 1996-12-13 | 1999-02-09 | Hoffmann-La Roche Inc. | Pyridone compounds useful in treating Alzheimer's disease |
US6037473A (en) | 1997-11-13 | 2000-03-14 | Haarmann & Reimer Gmbh | Use of substituted benzazoles as UV absorbers, new benzazoles and processes for their preparation |
CN100422180C (zh) | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
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- 2002-04-23 US US10/127,678 patent/US6696039B2/en not_active Expired - Lifetime
- 2002-04-23 TW TW091108360A patent/TWI245764B/zh not_active IP Right Cessation
- 2002-04-23 DE DE60217090T patent/DE60217090T2/de not_active Expired - Lifetime
- 2002-04-23 AU AU2002258915A patent/AU2002258915B2/en not_active Ceased
- 2002-04-23 JP JP2002583430A patent/JP4317955B2/ja not_active Expired - Fee Related
- 2002-04-23 CA CA002444214A patent/CA2444214A1/en not_active Abandoned
- 2002-04-23 KR KR10-2003-7013709A patent/KR20040058111A/ko not_active Application Discontinuation
- 2002-04-23 EP EP02728893A patent/EP1381604B1/de not_active Expired - Lifetime
- 2002-04-23 AT AT02728893T patent/ATE349446T1/de not_active IP Right Cessation
- 2002-04-23 ES ES02728893T patent/ES2274973T3/es not_active Expired - Lifetime
- 2002-04-23 WO PCT/US2002/012626 patent/WO2002085903A2/en active IP Right Grant
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Also Published As
Publication number | Publication date |
---|---|
DE60217090T2 (de) | 2007-07-12 |
KR20040058111A (ko) | 2004-07-03 |
TWI245764B (en) | 2005-12-21 |
US6946116B2 (en) | 2005-09-20 |
EP1381604B1 (de) | 2006-12-27 |
JP4317955B2 (ja) | 2009-08-19 |
USRE44338E1 (en) | 2013-07-02 |
AU2002258915B2 (en) | 2007-11-15 |
WO2002085903A2 (en) | 2002-10-31 |
EP1381604A2 (de) | 2004-01-21 |
US20030059369A1 (en) | 2003-03-27 |
CN100422180C (zh) | 2008-10-01 |
US7425318B2 (en) | 2008-09-16 |
US20060051293A1 (en) | 2006-03-09 |
US6696039B2 (en) | 2004-02-24 |
CN1620454A (zh) | 2005-05-25 |
JP2005512945A (ja) | 2005-05-12 |
US20040131545A1 (en) | 2004-07-08 |
CA2444214A1 (en) | 2002-10-31 |
DE60217090D1 (de) | 2007-02-08 |
USRE44354E1 (en) | 2013-07-09 |
ES2274973T3 (es) | 2007-06-01 |
WO2002085903A3 (en) | 2003-02-27 |
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