MX2009009113A - Nuevos indoles 2-heteroaril sustituidos 695. - Google Patents
Nuevos indoles 2-heteroaril sustituidos 695.Info
- Publication number
- MX2009009113A MX2009009113A MX2009009113A MX2009009113A MX2009009113A MX 2009009113 A MX2009009113 A MX 2009009113A MX 2009009113 A MX2009009113 A MX 2009009113A MX 2009009113 A MX2009009113 A MX 2009009113A MX 2009009113 A MX2009009113 A MX 2009009113A
- Authority
- MX
- Mexico
- Prior art keywords
- novel
- heteroaryl substituted
- relates
- alzheimer
- compositions
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 4
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002243 precursor Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a nuevos derivados de indol 2-heteroaril sustituidos, a precursores de los mismos y a usos terapéuticos de estos compuestos, que tienen la siguiente fórmula estructural (la): y a su sal farmacéuticamente aceptable, a composiciones y métodos de uso. Además, la invención se refiere a nuevos derivados de indol 2-heteroaril sustituidos que son adecuados para formar imágenes de depósitos amiloides en pacientes vivos, a sus composiciones, métodos de uso y procedimientos para elaborar estos compuestos. Más específicamente, la presente invención se refiere a un método para crear imágenes de depósitos amiloides en cerebro in vivo para permitir el diagnóstico ante-mortem de enfermedad de Alzheimer así como para medir la eficacia clínica de agentes terapéuticos para enfermedad de Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89315107P | 2007-03-06 | 2007-03-06 | |
| PCT/SE2008/050242 WO2008108729A1 (en) | 2007-03-06 | 2008-03-05 | Novel 2-heteroaryl substituted indoles 695 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009009113A true MX2009009113A (es) | 2009-09-04 |
Family
ID=39738509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009009113A MX2009009113A (es) | 2007-03-06 | 2008-03-05 | Nuevos indoles 2-heteroaril sustituidos 695. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100098631A1 (es) |
| EP (1) | EP2121655A4 (es) |
| JP (1) | JP2010520275A (es) |
| KR (1) | KR20090115954A (es) |
| CN (1) | CN101636395A (es) |
| AU (1) | AU2008221667A1 (es) |
| BR (1) | BRPI0808090A2 (es) |
| CA (1) | CA2680055A1 (es) |
| MX (1) | MX2009009113A (es) |
| RU (1) | RU2009133256A (es) |
| WO (1) | WO2008108729A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2725940A1 (en) | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| PA8843701A1 (es) * | 2008-09-29 | 2010-05-26 | Abbott Lab | Derivados de indolina y métodos para usarlos |
| EP2501696B1 (en) | 2009-10-15 | 2016-12-28 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| CN114380731A (zh) * | 2022-03-09 | 2022-04-22 | 台州学院 | 一种kcnq钾离子通道激动剂、药物组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100422180C (zh) * | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
| CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| JP2008545663A (ja) * | 2005-05-27 | 2008-12-18 | クイーンズ ユニバーシティ アット キングストン | タンパク質フォールディング障害の治療 |
-
2008
- 2008-03-05 JP JP2009552640A patent/JP2010520275A/ja active Pending
- 2008-03-05 US US12/529,850 patent/US20100098631A1/en not_active Abandoned
- 2008-03-05 KR KR1020097018582A patent/KR20090115954A/ko not_active Application Discontinuation
- 2008-03-05 WO PCT/SE2008/050242 patent/WO2008108729A1/en active Application Filing
- 2008-03-05 RU RU2009133256/04A patent/RU2009133256A/ru not_active Application Discontinuation
- 2008-03-05 MX MX2009009113A patent/MX2009009113A/es not_active Application Discontinuation
- 2008-03-05 CA CA002680055A patent/CA2680055A1/en not_active Abandoned
- 2008-03-05 EP EP08724189A patent/EP2121655A4/en not_active Withdrawn
- 2008-03-05 BR BRPI0808090-9A2A patent/BRPI0808090A2/pt not_active IP Right Cessation
- 2008-03-05 AU AU2008221667A patent/AU2008221667A1/en not_active Abandoned
- 2008-03-05 CN CN200880007424A patent/CN101636395A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2121655A1 (en) | 2009-11-25 |
| EP2121655A4 (en) | 2010-09-22 |
| CN101636395A (zh) | 2010-01-27 |
| CA2680055A1 (en) | 2008-09-12 |
| AU2008221667A1 (en) | 2008-09-12 |
| KR20090115954A (ko) | 2009-11-10 |
| BRPI0808090A2 (pt) | 2014-06-17 |
| WO2008108729A1 (en) | 2008-09-12 |
| JP2010520275A (ja) | 2010-06-10 |
| US20100098631A1 (en) | 2010-04-22 |
| RU2009133256A (ru) | 2011-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |