CY1109348T1 - Διυδρο-θειενο-πυριμιδινες για τη θεραπεια φλεγμονωδων παθησεων - Google Patents

Διυδρο-θειενο-πυριμιδινες για τη θεραπεια φλεγμονωδων παθησεων

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Publication number
CY1109348T1
CY1109348T1 CY20091100939T CY091100939T CY1109348T1 CY 1109348 T1 CY1109348 T1 CY 1109348T1 CY 20091100939 T CY20091100939 T CY 20091100939T CY 091100939 T CY091100939 T CY 091100939T CY 1109348 T1 CY1109348 T1 CY 1109348T1
Authority
CY
Cyprus
Prior art keywords
treatment
diseases
dihydro
pyrimides
sulfur
Prior art date
Application number
CY20091100939T
Other languages
English (en)
Inventor
Pascale Pouzet
Christoph Hoenke
Domnic Martyres
Peter Nickolaus
Birgit Jung
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1109348T1 publication Critical patent/CY1109348T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Η εφεύρεση αφορά νέες διυδρο-θειενο-πυριμιδίνες του τύπου 1, καθώς και τα φαρμακολογικά αποδεκτά άλατα, τα διαστερεοϊσομερή, τα εναντιομερή, τα ρακεμικά μείγματα, τις ένυδρες και τις επιδιαλυτωμένες ενώσεις αυτών που είναι κατάλληλα για τη θεραπεία συμπτωμάτων ή παθήσεων των αναπνευστικών οδών, γαστρεντερικών συμπτωμάτων ή παθήσεων, φλεγμονωδών παθήσεων των αρθρώσεων, του δέρματος ή των οφθαλμών, παθήσεων του περιφερικού και του κεντρικού νευρικού συστήματος ή καρκινικών παθήσεων, καθώς και φαρμακευτικές συνθέσεις, οι οποίες περιέχουν τις ενώσεις αυτές.
CY20091100939T 2006-04-19 2009-09-10 Διυδρο-θειενο-πυριμιδινες για τη θεραπεια φλεγμονωδων παθησεων CY1109348T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005019201A DE102005019201A1 (de) 2006-04-19 2006-04-19 Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen
EP06743350A EP1874781B9 (de) 2006-04-19 2006-04-19 Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen

Publications (1)

Publication Number Publication Date
CY1109348T1 true CY1109348T1 (el) 2014-07-02

Family

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Family Applications (1)

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CY20091100939T CY1109348T1 (el) 2006-04-19 2009-09-10 Διυδρο-θειενο-πυριμιδινες για τη θεραπεια φλεγμονωδων παθησεων

Country Status (28)

Country Link
US (3) US7511045B2 (el)
EP (2) EP2060575A1 (el)
JP (1) JP5021624B2 (el)
KR (1) KR101335964B1 (el)
CN (1) CN101163706A (el)
AR (1) AR053235A1 (el)
AT (1) ATE434620T1 (el)
AU (1) AU2006237354B2 (el)
BR (1) BRPI0608387A2 (el)
CA (1) CA2605161A1 (el)
CY (1) CY1109348T1 (el)
DE (2) DE502006004066D1 (el)
DK (1) DK1874781T3 (el)
EA (1) EA013108B1 (el)
ES (1) ES2328400T3 (el)
HR (1) HRP20090395T1 (el)
IL (1) IL186749A (el)
MX (1) MX2007012313A (el)
NO (1) NO20074615L (el)
NZ (1) NZ563488A (el)
PL (1) PL1874781T3 (el)
PT (1) PT1874781E (el)
RS (1) RS51163B (el)
SI (1) SI1874781T1 (el)
TW (1) TWI380984B (el)
UA (1) UA93872C2 (el)
WO (1) WO2006111549A1 (el)
ZA (1) ZA200707591B (el)

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PL1874781T3 (pl) 2009-12-31
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ATE434620T1 (de) 2009-07-15
US20070259846A1 (en) 2007-11-08
NZ563488A (en) 2010-04-30
JP2008536890A (ja) 2008-09-11
US8354531B2 (en) 2013-01-15
WO2006111549A1 (de) 2006-10-26
US7723341B2 (en) 2010-05-25
EA200702200A1 (ru) 2008-04-28
US7511045B2 (en) 2009-03-31
UA93872C2 (ru) 2011-03-25
KR101335964B1 (ko) 2013-12-04
DE102005019201A1 (de) 2006-11-02
BRPI0608387A2 (pt) 2009-12-29
AR053235A1 (es) 2007-04-25
KR20080004621A (ko) 2008-01-09
EA013108B1 (ru) 2010-02-26
RS51163B (sr) 2010-10-31
NO20074615L (no) 2007-11-19
CA2605161A1 (en) 2006-10-26
EP1874781B9 (de) 2010-09-08
IL186749A (en) 2014-08-31
DK1874781T3 (da) 2009-11-02
US20100197656A1 (en) 2010-08-05
JP5021624B2 (ja) 2012-09-12
ES2328400T3 (es) 2009-11-12
HRP20090395T1 (hr) 2009-08-31
EP1874781B1 (de) 2009-06-24
MX2007012313A (es) 2007-11-21
EP2060575A1 (de) 2009-05-20
ZA200707591B (en) 2009-08-26
US20090186875A1 (en) 2009-07-23
EP1874781A1 (de) 2008-01-09
AU2006237354B2 (en) 2012-03-01
DE502006004066D1 (de) 2009-08-06
IL186749A0 (en) 2008-02-09
CN101163706A (zh) 2008-04-16
PT1874781E (pt) 2009-07-27
TWI380984B (zh) 2013-01-01
AU2006237354A1 (en) 2006-10-26

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