CY1110977T1 - Υποκατεστημενα παραγωγα ινδολης για φαρμακευτικη συνθεση για θεραπεια ασθενειων του αναπνευστικου - Google Patents
Υποκατεστημενα παραγωγα ινδολης για φαρμακευτικη συνθεση για θεραπεια ασθενειων του αναπνευστικουInfo
- Publication number
- CY1110977T1 CY1110977T1 CY20101101133T CY101101133T CY1110977T1 CY 1110977 T1 CY1110977 T1 CY 1110977T1 CY 20101101133 T CY20101101133 T CY 20101101133T CY 101101133 T CY101101133 T CY 101101133T CY 1110977 T1 CY1110977 T1 CY 1110977T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical composition
- respiratory disease
- disease treatment
- indole derivatives
- substituted indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η παρούσα εφεύρεση αναφέρεται σε υποκατεστημένες ινδόλες του τύπου (I) χρήσιμες ως φαρμακευτικές ενώσεις για τη θεραπεία αναπνευστικών διαταραχών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0302232A SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Novel Compounds |
EP04768065A EP1656347B1 (en) | 2003-08-18 | 2004-08-16 | Substituted indole derivatives for pharmaceutical composition for treating respiratory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110977T1 true CY1110977T1 (el) | 2015-06-11 |
Family
ID=28450248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101101133T CY1110977T1 (el) | 2003-08-18 | 2010-12-09 | Υποκατεστημενα παραγωγα ινδολης για φαρμακευτικη συνθεση για θεραπεια ασθενειων του αναπνευστικου |
Country Status (18)
Country | Link |
---|---|
US (1) | US7709521B2 (el) |
EP (1) | EP1656347B1 (el) |
JP (1) | JP4709758B2 (el) |
AR (1) | AR045462A1 (el) |
AT (1) | ATE484494T1 (el) |
CY (1) | CY1110977T1 (el) |
DE (1) | DE602004029580D1 (el) |
DK (1) | DK1656347T3 (el) |
ES (1) | ES2352201T3 (el) |
MY (1) | MY143367A (el) |
PL (1) | PL1656347T3 (el) |
PT (1) | PT1656347E (el) |
SA (1) | SA04250255B1 (el) |
SE (1) | SE0302232D0 (el) |
SI (1) | SI1656347T1 (el) |
TW (1) | TW200510303A (el) |
UY (1) | UY28473A1 (el) |
WO (1) | WO2005019171A1 (el) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
DE602005006539D1 (de) | 2004-03-11 | 2008-06-19 | Actelion Pharmaceuticals Ltd | Tetrahydropyridoindolderivate |
MX2007007691A (es) | 2004-12-27 | 2007-08-14 | Actelion Pharmaceuticals Ltd | Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2. |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
WO2007010965A1 (ja) | 2005-07-22 | 2007-01-25 | Shionogi & Co., Ltd. | Pgd2受容体アンタゴニスト活性を有するアザインドール酸誘導体 |
EP2397476A3 (en) | 2005-07-22 | 2011-12-28 | Shionogi & Co., Ltd. | Indole derivative having PGD2 receptor antagonist activity |
GB0521275D0 (en) * | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
CN102558021A (zh) * | 2006-05-26 | 2012-07-11 | 阿斯利康(瑞典)有限公司 | 联芳基或芳基-杂芳基取代的吲哚类化合物 |
US20150072963A1 (en) * | 2006-06-16 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
WO2007149312A2 (en) | 2006-06-16 | 2007-12-27 | The Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and bph |
ES2391671T3 (es) | 2006-07-22 | 2012-11-28 | Oxagen Limited | Compuestos con actividad antagonista de CRTH2 |
PT2051962E (pt) | 2006-08-07 | 2012-01-10 | Actelion Pharmaceuticals Ltd | Derivados do ácido (3-amino-1,2,3,4-tetrahidro-9hcarbazol- 9-il)-acético |
ES2431815T3 (es) | 2007-04-11 | 2013-11-28 | Kissei Pharmaceutical Co., Ltd. | Derivado de (aza)indol y uso del mismo para fines médicos |
US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
DE602008005796D1 (de) | 2007-12-14 | 2011-05-05 | Pulmagen Therapeutics Asthma Ltd | Indole und ihre therapeutische verwendung |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
KR101644170B1 (ko) | 2008-01-18 | 2016-08-01 | 옥사겐 리미티드 | 씨알티에이치2 길항제 활성을 갖는 화합물 |
US8168673B2 (en) | 2008-01-22 | 2012-05-01 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
JP2011509990A (ja) | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
EP2377851A4 (en) | 2008-12-25 | 2012-06-20 | Taisho Pharmaceutical Co Ltd | isoquinoline |
ES2628219T3 (es) * | 2009-05-19 | 2017-08-02 | Vivia Biotech S.L. | Métodos para proporcionar ensayos de medicina personalizada ex vivo para neoplasias hematológicas |
ES2426679T3 (es) * | 2009-07-06 | 2013-10-24 | Astrazeneca Ab | Intermedios y procesos para preparar el ácido 4-(acetilamino)-3-[(4-clorofenil)tio]-2-metil-1H-indol-1-acético |
CA2789427A1 (en) * | 2010-02-11 | 2011-08-18 | Vanderbilt University | Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
AU2011231208B2 (en) | 2010-03-22 | 2015-03-26 | Idorsia Pharmaceuticals Ltd | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators |
CN103119024A (zh) | 2010-06-23 | 2013-05-22 | 大正制药株式会社 | 异喹啉衍生物 |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
SG193902A1 (en) | 2011-04-14 | 2013-11-29 | Actelion Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
MX2014007239A (es) | 2011-12-16 | 2014-08-08 | Atopix Therapeutics Ltd | Combinacion de un antagonista crth2 y un inhibidor de bomba de proton para el tratamiento de esofagitis eosinofilica. |
CN104602763B (zh) * | 2012-03-21 | 2018-08-21 | 宾夕法尼亚大学理事会 | 用于调节毛发生长的组合物和方法 |
BR112016021471B1 (pt) | 2014-03-17 | 2022-10-11 | Idorsia Pharmaceuticals Ltd | Compostos derivados de ácido acético azaindol, composição farmacêutica, e, uso de um composto |
US9850241B2 (en) | 2014-03-18 | 2017-12-26 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
TWI695831B (zh) | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Crth2拮抗劑化合物及其用途 |
EP3328500B1 (en) | 2015-07-30 | 2023-04-12 | The Trustees of the University of Pennsylvania | Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2 antagonists |
KR20180053345A (ko) | 2015-09-15 | 2018-05-21 | 이도르시아 파마슈티컬스 리미티드 | 결정질 형태 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790679A (fr) * | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
JPH0615542B2 (ja) | 1986-07-22 | 1994-03-02 | 吉富製薬株式会社 | ピラゾロピリジン化合物 |
US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
WO1993005020A1 (en) | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
FR2692574B1 (fr) | 1992-06-23 | 1995-06-23 | Sanofi Elf | Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles. |
CA2156420A1 (en) | 1993-02-24 | 1994-09-01 | Theresa M. Williams | Inhibitors of hiv reverse transcriptase |
US5486525A (en) * | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
US5567711A (en) * | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
TW472045B (en) | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
AR017256A1 (es) | 1997-08-21 | 2001-09-05 | American Home Prod | Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprenden |
DK0924209T3 (da) | 1997-12-19 | 2003-08-25 | Lilly Co Eli | Hypoglykæmiske imidazolinforbindelser |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
WO2000078761A1 (en) | 1999-06-23 | 2000-12-28 | Sepracor, Inc. | Indolyl-benzimidazole antibacterials, and methods of use thereof |
WO2001032621A1 (fr) | 1999-10-29 | 2001-05-10 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif |
HUP0203895A3 (en) | 1999-12-24 | 2004-09-28 | Aventis Pharma Ltd West Mallin | Substituted azaindoles and pharmaceutical compositions containing them and their use |
WO2001092224A1 (en) * | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
US6933316B2 (en) * | 2001-12-13 | 2005-08-23 | National Health Research Institutes | Indole compounds |
PL373410A1 (en) | 2002-02-01 | 2005-08-22 | F.Hoffman-La Roche Ag | Substituted indoles as alpha-1 agonists |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
JP4484108B2 (ja) | 2002-05-16 | 2010-06-16 | 塩野義製薬株式会社 | Pgd2受容体拮抗作用を有する化合物 |
SE0201635D0 (sv) * | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
JP2007508363A (ja) | 2003-10-14 | 2007-04-05 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
CN102558021A (zh) | 2006-05-26 | 2012-07-11 | 阿斯利康(瑞典)有限公司 | 联芳基或芳基-杂芳基取代的吲哚类化合物 |
AU2007256564A1 (en) | 2006-06-08 | 2007-12-13 | Neurokey A/S | Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia |
EP2040688B1 (en) | 2006-06-28 | 2014-04-02 | Sanofi | New cxcr2 inhibitors |
-
2003
- 2003-08-18 SE SE0302232A patent/SE0302232D0/xx unknown
-
2004
- 2004-08-06 TW TW093123728A patent/TW200510303A/zh unknown
- 2004-08-16 PL PL04768065T patent/PL1656347T3/pl unknown
- 2004-08-16 WO PCT/GB2004/003502 patent/WO2005019171A1/en active Search and Examination
- 2004-08-16 SA SA04250255A patent/SA04250255B1/ar unknown
- 2004-08-16 ES ES04768065T patent/ES2352201T3/es active Active
- 2004-08-16 MY MYPI20043328A patent/MY143367A/en unknown
- 2004-08-16 DE DE602004029580T patent/DE602004029580D1/de active Active
- 2004-08-16 DK DK04768065.7T patent/DK1656347T3/da active
- 2004-08-16 SI SI200431554T patent/SI1656347T1/sl unknown
- 2004-08-16 US US10/568,889 patent/US7709521B2/en not_active Expired - Fee Related
- 2004-08-16 JP JP2006523677A patent/JP4709758B2/ja not_active Expired - Fee Related
- 2004-08-16 EP EP04768065A patent/EP1656347B1/en not_active Not-in-force
- 2004-08-16 AT AT04768065T patent/ATE484494T1/de active
- 2004-08-16 PT PT04768065T patent/PT1656347E/pt unknown
- 2004-08-17 UY UY28473A patent/UY28473A1/es unknown
- 2004-08-18 AR ARP040102959A patent/AR045462A1/es not_active Application Discontinuation
-
2010
- 2010-12-09 CY CY20101101133T patent/CY1110977T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP4709758B2 (ja) | 2011-06-22 |
SI1656347T1 (sl) | 2011-01-31 |
WO2005019171A1 (en) | 2005-03-03 |
TW200510303A (en) | 2005-03-16 |
JP2007502804A (ja) | 2007-02-15 |
DE602004029580D1 (de) | 2010-11-25 |
ATE484494T1 (de) | 2010-10-15 |
MY143367A (en) | 2011-04-29 |
UY28473A1 (es) | 2005-03-31 |
DK1656347T3 (da) | 2011-01-10 |
PT1656347E (pt) | 2010-12-09 |
AR045462A1 (es) | 2005-10-26 |
EP1656347B1 (en) | 2010-10-13 |
PL1656347T3 (pl) | 2011-02-28 |
US7709521B2 (en) | 2010-05-04 |
EP1656347A1 (en) | 2006-05-17 |
ES2352201T3 (es) | 2011-02-16 |
SA04250255B1 (ar) | 2009-02-25 |
SE0302232D0 (sv) | 2003-08-18 |
US20060264444A1 (en) | 2006-11-23 |
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