SI1656347T1 - Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni - Google Patents

Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni

Info

Publication number
SI1656347T1
SI1656347T1 SI200431554T SI200431554T SI1656347T1 SI 1656347 T1 SI1656347 T1 SI 1656347T1 SI 200431554 T SI200431554 T SI 200431554T SI 200431554 T SI200431554 T SI 200431554T SI 1656347 T1 SI1656347 T1 SI 1656347T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical composition
respiratory diseases
indole derivatives
substituted indole
treating respiratory
Prior art date
Application number
SI200431554T
Other languages
English (en)
Inventor
Roger Victor Bonnert
Anthony Ronald Cook
Timothy Jon Luker
Rukhsana Tasneem Mohammed
Stephen Thom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SI1656347T1 publication Critical patent/SI1656347T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200431554T 2003-08-18 2004-08-16 Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni SI1656347T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0302232A SE0302232D0 (sv) 2003-08-18 2003-08-18 Novel Compounds
EP04768065A EP1656347B1 (en) 2003-08-18 2004-08-16 Substituted indole derivatives for pharmaceutical composition for treating respiratory diseases
PCT/GB2004/003502 WO2005019171A1 (en) 2003-08-18 2004-08-16 Substituted indole derivatives for pharmaceutical composition for treating respiratory diseases

Publications (1)

Publication Number Publication Date
SI1656347T1 true SI1656347T1 (sl) 2011-01-31

Family

ID=28450248

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431554T SI1656347T1 (sl) 2003-08-18 2004-08-16 Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni

Country Status (18)

Country Link
US (1) US7709521B2 (sl)
EP (1) EP1656347B1 (sl)
JP (1) JP4709758B2 (sl)
AR (1) AR045462A1 (sl)
AT (1) ATE484494T1 (sl)
CY (1) CY1110977T1 (sl)
DE (1) DE602004029580D1 (sl)
DK (1) DK1656347T3 (sl)
ES (1) ES2352201T3 (sl)
MY (1) MY143367A (sl)
PL (1) PL1656347T3 (sl)
PT (1) PT1656347E (sl)
SA (1) SA04250255B1 (sl)
SE (1) SE0302232D0 (sl)
SI (1) SI1656347T1 (sl)
TW (1) TW200510303A (sl)
UY (1) UY28473A1 (sl)
WO (1) WO2005019171A1 (sl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
DK1725553T3 (da) 2004-03-11 2008-08-18 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivater
BRPI0519280A2 (pt) 2004-12-27 2009-01-06 Actelion Pharmaceuticals Ltd composto, composiÇço farmacÊutica e uso de um composto
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
EP1916245B1 (en) 2005-07-22 2011-10-26 Shionogi & Co., Ltd. Indole derivative having pgd2 receptor antagonist activity
WO2007010965A1 (ja) 2005-07-22 2007-01-25 Shionogi & Co., Ltd. Ｐｇｄ２受容体アンタゴニスト活性を有するアザインドール酸誘導体
GB0521275D0 (en) * 2005-10-19 2005-11-30 Argenta Discovery Ltd 3-Aminoindole compounds
EP2125722A2 (en) * 2006-05-26 2009-12-02 AstraZeneca AB Bi-aryl or aryl-heteroaryl substituted indoles
SI2037967T1 (sl) 2006-06-16 2017-04-26 The Trustees Of The University Of Pennsylvania Antagonisti receptorja za prostaglandin d2 za zdravljenje androgene alopecije
US20150072963A1 (en) * 2006-06-16 2015-03-12 The Trustees Of The University Of Pennsylvania Compositions and methods for regulating hair growth
RU2458918C2 (ru) 2006-07-22 2012-08-20 Оксаген Лимитед Соединения, обладающие антагонистической активностью по отношению к crth2
CN101500996B (zh) 2006-08-07 2012-07-04 埃科特莱茵药品有限公司 (3-胺基-1,2,3,4-四氢-9h-咔唑-9-基)-乙酸衍生物
CA2682391C (en) 2007-04-11 2014-07-08 Kissei Pharmaceutical Co., Ltd. (aza)indole derivative and use thereof for medical purposes
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
DK2229358T3 (da) 2007-12-14 2011-07-04 Pulmagen Therapeutics Asthma Ltd Indoler og deres terapeutiske anvendelse
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
RU2503672C2 (ru) 2008-01-18 2014-01-10 Оксаген Лимитед Соединения, обладающие активностью антагонистов crth2
EP2265581A1 (en) 2008-01-22 2010-12-29 Oxagen Limited Compounds having crth2 antagonist activity
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
WO2010074244A1 (ja) * 2008-12-25 2010-07-01 大正製薬株式会社 イソキノリン誘導体
MX2011012267A (es) * 2009-05-19 2012-04-11 Vivia Biotech Sl Metodos para proveer pruebas de medicina personalizadas ex vivo en cuanto a neoplasmas hematologicos.
CN102482214B (zh) * 2009-07-06 2014-08-27 阿斯利康(瑞典)有限公司 制备4-(乙酰基氨基)-3-[(4-氯-苯基)硫基]-2-甲基-1h-吲哚-1-乙酸的中间体和方法
CN102892288B (zh) 2010-02-11 2016-02-24 范德比尔特大学 作为亲代谢性谷氨酸受体4(mGLuR4)变构增效剂的吡唑并吡啶化合物、吡唑并吡嗪化合物、吡唑并吡嘧啶化合物、吡唑并噻吩化合物和吡唑并噻唑化合物，组合物，以及其治疗神经学上的功能失调的方法
SI2558447T1 (sl) 2010-03-22 2015-01-30 Actelion Pharmaceuticals Ltd. Derivati 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-karbazola in njihova uporaba kot modulatorji prostaglandinskega receptorja d2
CN103119024A (zh) 2010-06-23 2013-05-22 大正制药株式会社 异喹啉衍生物
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
BR112013026283A8 (pt) 2011-04-14 2018-01-30 Actelion Pharmaceuticals Ltd derivados de ácido 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indol acético e seu uso como moduladores do receptor d2 de prostaglandina
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
US20140328861A1 (en) 2011-12-16 2014-11-06 Atopix Therapeutics Limited Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis
EA033143B1 (ru) * 2012-03-21 2019-09-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Способ и применение селективного антагониста dp-2 по отношению к dp-1 для стимулирования роста волос
AR099767A1 (es) 2014-03-17 2016-08-17 Actelion Pharmaceuticals Ltd Derivados del ácido acético azaindol y su uso como moduladores del receptor de prostaglandina d2
CN106103437A (zh) 2014-03-18 2016-11-09 埃科特莱茵药品有限公司 氮杂吲哚乙酸衍生物及其作为前列腺素d2受体调节剂的用途
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
TWI695831B (zh) 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Ｃｒｔｈ２拮抗劑化合物及其用途
EP4420734A2 (en) 2015-02-13 2024-08-28 Institut National de la Santé et de la Recherche Médicale Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
WO2017019858A1 (en) 2015-07-30 2017-02-02 The Trustees Of The University Of Pennsylvania Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2
US10351560B2 (en) 2015-09-15 2019-07-16 Idorsia Pharmaceuticals Ltd Crystalline forms

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790679A (fr) * 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
JPH0615542B2 (ja) 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
FR2692574B1 (fr) 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
PL175788B1 (pl) 1993-02-24 1999-02-26 Merck & Co Inc Amidowe pochodne indolu i zawierające je kompozycje farmaceutyczne
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
ZA987554B (en) 1997-08-21 2000-02-21 American Home Prod Methods for the solid phase synthesis of substituted indole compounds.
ZA9811672B (en) 1997-12-19 2000-06-19 Lilly Co Eli Hypoglycemic imidazoline compounds.
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
AU5886500A (en) 1999-06-23 2001-01-09 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
AU7962200A (en) 1999-10-29 2001-05-14 Wakunaga Pharmaceutical Co., Ltd Novel indole derivatives and drugs containing the same as the active ingredient
CA2699568C (en) 1999-12-24 2013-03-12 Aventis Pharma Limited Azaindoles
JP2003535078A (ja) * 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ 血管損傷活性のあるインドール誘導体
US6878522B2 (en) * 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
US6933316B2 (en) * 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
JP4209332B2 (ja) 2002-02-01 2009-01-14 エフ．ホフマン−ラ ロシュ アーゲー α−１アゴニストとしての置換インドール
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
AU2003231509A1 (en) * 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
WO2005040114A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
EP2125722A2 (en) * 2006-05-26 2009-12-02 AstraZeneca AB Bi-aryl or aryl-heteroaryl substituted indoles
RU2008152763A (ru) 2006-06-08 2010-07-20 Ньюроки А/С (Dk) Применение агонистов каннабиноидного рецептора в качестве индуцирующих гипотермию лекарственных средств для лечения ишемии
AU2007264114A1 (en) 2006-06-28 2008-01-03 Sanofi-Aventis New CXCR2 inhibitors

Also Published As

Publication number Publication date
AR045462A1 (es) 2005-10-26
US7709521B2 (en) 2010-05-04
DK1656347T3 (da) 2011-01-10
WO2005019171A1 (en) 2005-03-03
MY143367A (en) 2011-04-29
JP2007502804A (ja) 2007-02-15
SA04250255B1 (ar) 2009-02-25
UY28473A1 (es) 2005-03-31
PL1656347T3 (pl) 2011-02-28
EP1656347B1 (en) 2010-10-13
SE0302232D0 (sv) 2003-08-18
US20060264444A1 (en) 2006-11-23
JP4709758B2 (ja) 2011-06-22
TW200510303A (en) 2005-03-16
DE602004029580D1 (de) 2010-11-25
EP1656347A1 (en) 2006-05-17
ES2352201T3 (es) 2011-02-16
PT1656347E (pt) 2010-12-09
ATE484494T1 (de) 2010-10-15
CY1110977T1 (el) 2015-06-11

Similar Documents

Publication Publication Date Title
SI1656347T1 (sl) Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni
SI1656346T1 (sl) 1,2,3,4-tetrasubstituiran indol za zdravljenje respiratornih bolezni
HUS1500058I1 (hu) Benzoxazint tartalmazó gyógyszer-kombináció légúti betegségek kezelésére
AP2005003283A0 (en) Indole derivatives useful for the treatment os diseases
GB0312832D0 (en) 2-amino-pyridine derivatives useful for the treatment of diseases
TWI369987B (en) New pharmaceutical compositions for the treatment of hyper-proliferative disorders
ZA200604352B (en) Azepinondole derivatives as pharmaceutical agents
EP1804787A4 (en) FLAVONOID COMPOSITION FOR THE TREATMENT OF BUCCO-DENTAL DISEASES
ZA200701584B (en) Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
HK1096588A1 (en) Therapeutic agent for mesothelioma
IL173908A0 (en) Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation
IL184934A0 (en) 4-oxoquinazoline-3-yl-benzamide derivatives for the treatment of cytokine diseases
IL187739A0 (en) New 2-azetidinone derivatives for the treatment of hyperlipidaemic diseases
SI1685125T1 (sl) Derivati pirola, primerni za zdravljenje proliferativnih bolezni
IL185444A0 (en) Novel drugs for treating respiratory diseases
EP1784173A4 (en) PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC BONE DISEASES CONTAINING ALPHA-ARYLMETHOXYACRYLATE DERIVATIVES
IL188856A0 (en) Novel piperidine derivatives as chemokine receptor modulators useful for the treatment of respiratory diseases
HUP0401523A3 (en) Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
HU0500145D0 (en) Composition for the treatment of oral diseases
GB0228305D0 (en) Therapeutic composition for respiratory delivery
ZA200603126B (en) Pharmaceutical compositions for therapeutic use
EP1490048A4 (en) PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF RESPIRATORY DISEASES
GB0408297D0 (en) Indole derivatives for the treatment of diseases
PL373154A1 (en) Pharmaceutical composition intended for treating nasal cavity
TWI350171B (en) Pharmaceutical compositions for treatment of cardio-cerebral-vascular diseases