DE60217090D1 - Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel - Google Patents

Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel

Info

Publication number
DE60217090D1
DE60217090D1 DE60217090T DE60217090T DE60217090D1 DE 60217090 D1 DE60217090 D1 DE 60217090D1 DE 60217090 T DE60217090 T DE 60217090T DE 60217090 T DE60217090 T DE 60217090T DE 60217090 D1 DE60217090 D1 DE 60217090D1
Authority
DE
Germany
Prior art keywords
diagnostic imaging
amyloid plaque
aggregation inhibitors
imaging products
plaque aggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60217090T
Other languages
English (en)
Other versions
DE60217090T2 (de
Inventor
Hank F Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Application granted granted Critical
Publication of DE60217090D1 publication Critical patent/DE60217090D1/de
Publication of DE60217090T2 publication Critical patent/DE60217090T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
DE60217090T 2001-04-23 2002-04-23 Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel Expired - Lifetime DE60217090T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28528201P 2001-04-23 2001-04-23
US285282P 2001-04-23
PCT/US2002/012626 WO2002085903A2 (en) 2001-04-23 2002-04-23 Amyloid plaque aggregation inhibitors and diagnostic imaging agents

Publications (2)

Publication Number Publication Date
DE60217090D1 true DE60217090D1 (de) 2007-02-08
DE60217090T2 DE60217090T2 (de) 2007-07-12

Family

ID=23093574

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217090T Expired - Lifetime DE60217090T2 (de) 2001-04-23 2002-04-23 Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel

Country Status (12)

Country Link
US (5) US6696039B2 (de)
EP (1) EP1381604B1 (de)
JP (1) JP4317955B2 (de)
KR (1) KR20040058111A (de)
CN (1) CN100422180C (de)
AT (1) ATE349446T1 (de)
AU (1) AU2002258915B2 (de)
CA (1) CA2444214A1 (de)
DE (1) DE60217090T2 (de)
ES (1) ES2274973T3 (de)
TW (1) TWI245764B (de)
WO (1) WO2002085903A2 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
GB0018473D0 (en) * 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU2001286702B2 (en) 2000-08-24 2008-03-13 University Of Pittsburgh Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease
AU2002258915B2 (en) * 2001-04-23 2007-11-15 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
US20050123477A1 (en) * 2002-02-13 2005-06-09 Ian Wilson Benzothiazole derivatives for in vivo imaging of amloid plaques
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
WO2004053071A2 (en) 2002-12-09 2004-06-24 Judith Kelleher-Andersson Method for discovering neurogenic agents
CN1774267A (zh) * 2003-01-22 2006-05-17 综合医院有限公司 与淀粉样物质结合的金属螯合剂
DK1611115T3 (da) * 2003-03-14 2012-11-26 Univ Pittsburgh Benzothiazolderivatforbindelser, sammensætninger og anvendelser deraf
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
GB0307855D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
WO2004100998A2 (en) 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
US20050049487A1 (en) * 2003-08-26 2005-03-03 Johnson Bruce Fletcher Compounds and kits for preparing imaging agents and methods of imaging
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
EP1732864B1 (de) * 2004-03-18 2013-12-25 Suntory Holdings Limited Radioaktiv markiertes 3-[3-(benzoylamido)benzyloxy]asparaginsäurederivat und verfahren zu dessen herstellung
US20080286202A1 (en) * 2004-07-02 2008-11-20 University Of Pittsburgh Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition
DK1771208T3 (da) * 2004-07-02 2013-09-02 Univ Pittsburgh Anvendelse af thioflavin radiomarkerede derivater i amyloid billeddannelse til vurdering af anti-amyloide terapier
US7803351B2 (en) * 2004-08-20 2010-09-28 Washington University Blood brain barrier permeation peptides
RU2434636C2 (ru) 2004-11-17 2011-11-27 Ньюралстем, Инк. Трансплантация нервных клеток для лечения нейродегенеративных состояний
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007011834A2 (en) * 2005-07-15 2007-01-25 The Regents Of The University Of California Compounds and method for the diagnosis and treatment of amyloid associated diseases
JP2009507032A (ja) 2005-09-02 2009-02-19 アボット・ラボラトリーズ 新規なイミダゾ系複素環
US20080219922A1 (en) * 2005-09-12 2008-09-11 Goodman Mark M Alzheimer's Disease Imaging Agents
AU2006325294B2 (en) † 2005-10-31 2012-10-11 Merck Sharp & Dohme Corp. CETP inhibitors
JP4738419B2 (ja) 2005-11-30 2011-08-03 富士フイルムＲｉファーマ株式会社 アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
US20090281120A1 (en) * 2005-12-12 2009-11-12 Ono Pharmaceutical Co., Ltd Bicyclic heterocyclic compound
EP1968961A2 (de) 2005-12-21 2008-09-17 Decode Genetics EHF Heterocyclische, stickstoffhaltige biarylinhibitoren von lta4h zur behandlung von entzündungen
TW200736252A (en) 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
WO2008118122A2 (en) * 2006-05-08 2008-10-02 Molecular Neuroimaging, Llc Compounds and amyloid probes thereof for therapeutic and imaging uses
EP2019103B1 (de) 2006-05-19 2011-11-30 Nihon Medi-Physics Co., Ltd. Verbindung mit affinität zu amyloid
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
US8277777B2 (en) * 2006-06-21 2012-10-02 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
WO2008056481A1 (fr) * 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Agent d'imagerie de diagnostic radioactif
US20090252680A1 (en) * 2006-11-17 2009-10-08 Nihon- Medi-Physics Co., Ltd Novel compound with affinity for amyloid
WO2008065785A1 (fr) 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Nouveau composé ayant une affinité pour l'amyloïde
AU2008208091A1 (en) * 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
WO2008099800A1 (ja) 2007-02-13 2008-08-21 Nihon Medi-Physics Co., Ltd. 放射性画像診断剤の製造方法
EP1964840A1 (de) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]pyridine und deren pharmazeutische Verwendung
MX2009009113A (es) * 2007-03-06 2009-09-04 Astrazeneca Ab Nuevos indoles 2-heteroaril sustituidos 695.
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
FR2913886B1 (fr) * 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
WO2008134618A2 (en) * 2007-04-27 2008-11-06 The General Hospital Corporation Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders
CA2703649A1 (en) * 2007-10-24 2009-04-30 Shigeyuki Tanifuji Novel compound having affinity for amyloid
AU2008314871A1 (en) 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
CN101909659A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
US20100249408A1 (en) * 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
CN102702195A (zh) * 2007-10-30 2012-10-03 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
CA2704172A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
EP2247558B1 (de) 2008-02-14 2022-02-02 Eli Lilly and Company Neue bildgebungsmittel für den nachweis neurologischer dysfunktionen
US20100331676A1 (en) * 2008-02-27 2010-12-30 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
JP5501339B2 (ja) * 2008-03-21 2014-05-21 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物
JP5603855B2 (ja) * 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
US8409419B2 (en) 2008-05-21 2013-04-02 Paul R. Kruesi Conversion of carbon to hydrocarbons
WO2009146388A1 (en) 2008-05-28 2009-12-03 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography
US8530483B2 (en) 2008-05-30 2013-09-10 Merck Sharp & Dohme Corp. Substituted azabenzoxazoles
EP2296474A1 (de) * 2008-05-30 2011-03-23 Merck Sharp & Dohme Corp. Neue substituierte indole
RU2010154473A (ru) * 2008-05-30 2012-07-10 Фостер Вилер Энергия Ой (Fi) Способ и устройство для генерации мощности сжиганием обогащенного кислородом топлива
KR20110046503A (ko) 2008-07-24 2011-05-04 지멘스 메디컬 솔루션즈 유에스에이, 인크. Ａｄ 병인을 확인하기에 유용한 영상화제
WO2010039815A1 (en) * 2008-09-30 2010-04-08 Case Western Reserve University Molecular probes for imaging of myelin
US20100145194A1 (en) * 2008-11-13 2010-06-10 Avid Radiopharmaceuticals, Inc. Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
EP2218464A1 (de) * 2009-02-11 2010-08-18 Technische Universität München Verbindungen zur nichtinvasiven Messung von Aggregaten von Amyloidpeptiden
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
CA2756137C (en) * 2009-03-23 2015-11-24 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological disorders
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
WO2011108236A1 (ja) * 2010-03-01 2011-09-09 日本メジフィジックス株式会社 放射性ヨウ素標識有機化合物またはその塩
MX341316B (es) 2010-07-28 2016-08-15 Neuralstem Inc * Poblacion de celulas madre neurales para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos.
EP3263136A1 (de) 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Abbildung von meningiomen mit stilben- oder biphenylalkynderivaten
EP2640703A1 (de) * 2010-11-16 2013-09-25 GE Healthcare UK Limited Heterocyclische verbindungen als bildgebungssonden der tau-pathologie
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2725027B1 (de) 2011-06-24 2017-03-01 Nihon Medi-Physics Co., Ltd. Neue verbindungen mit amyloidaffinität
FR2980364B1 (fr) 2011-09-26 2018-08-31 Guerbet Nanoemulsions et leur utilisation comme agents de contraste
WO2013082508A1 (en) * 2011-12-02 2013-06-06 The Regents Of The University Of Michigan Compositions and methods for the treatment and analysis of neurological disorders
WO2014004664A2 (en) 2012-06-27 2014-01-03 Mayo Foundation For Medical Education And Research Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
US9855276B2 (en) 2012-10-25 2018-01-02 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
CN103073520B (zh) * 2012-12-24 2014-10-08 湖南大学 一种合成2-苯基苯并噻唑及其衍生物的方法
FR3001154B1 (fr) 2013-01-23 2015-06-26 Guerbet Sa Magneto-emulsion vectorisee
WO2014124334A2 (en) 2013-02-08 2014-08-14 Misfolding Diagnostics, Inc. Transthyretin antibodies and uses thereof
WO2014177458A1 (en) 2013-04-29 2014-11-06 F. Hoffmann-La Roche Ag 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CA2920068A1 (en) * 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines as imaging tools
CN110305095A (zh) 2013-10-22 2019-10-08 综合医院公司 色甘酸衍生物以及成像和治疗的相关方法
CN107148275A (zh) 2014-10-20 2017-09-08 神经干细胞公司 包含编码生长因子的外源多核苷酸的稳定的神经干细胞及其使用方法
EP3384960B1 (de) * 2015-12-30 2019-06-05 Neuboron Medtech Ltd. Neutroneneinfangtherapiesystem zur beseitigung von amyloid-beta-protein
RU2721845C2 (ru) * 2015-12-30 2020-05-25 Нойборон Медтех Лтд. СОЕДИНЕНИЕ ДЛЯ СПЕЦИФИЧЕСКОГО СВЯЗЫВАНИЯ С β-АМИЛОИДОМ
AU2017321782B2 (en) 2016-08-31 2022-03-10 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
MX2020000577A (es) 2017-07-20 2020-09-10 Aztherapies Inc Formulaciones en polvo de cromolina sodica e ibuprofeno.
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
EP3817739A4 (de) 2018-07-02 2022-04-13 The General Hospital Corporation Pulverförmige formulierungen aus cromolyn-natrium und alpha-lactose
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
KR102240400B1 (ko) * 2020-11-19 2021-04-15 한국원자력연구원 베타-아밀로이드 검출용 수용성 화합물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317949D0 (en) 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
US5552415A (en) * 1993-12-21 1996-09-03 Eli Lilly And Company Method of inhibiting Alzheimer's Disease
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6417178B1 (en) 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
US6054114A (en) * 1996-05-08 2000-04-25 Massachusetts Institute Of Technology Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro
EP0973513A4 (de) 1996-10-23 2003-03-19 Zymogenetics Inc Zusammenstellungen und verfahren zur behandlung von knochenmangelerscheinungen
US5869500A (en) 1996-12-13 1999-02-09 Hoffmann-La Roche Inc. Pyridone compounds useful in treating Alzheimer's disease
US6037473A (en) 1997-11-13 2000-03-14 Haarmann & Reimer Gmbh Use of substituted benzazoles as UV absorbers, new benzazoles and processes for their preparation
AU2002258915B2 (en) * 2001-04-23 2007-11-15 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents

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JP2005512945A (ja) 2005-05-12
USRE44354E1 (en) 2013-07-09
EP1381604B1 (de) 2006-12-27
DE60217090T2 (de) 2007-07-12
US20030059369A1 (en) 2003-03-27
CN1620454A (zh) 2005-05-25
WO2002085903A3 (en) 2003-02-27
EP1381604A2 (de) 2004-01-21
ATE349446T1 (de) 2007-01-15
KR20040058111A (ko) 2004-07-03
US6946116B2 (en) 2005-09-20
US20060051293A1 (en) 2006-03-09
AU2002258915B2 (en) 2007-11-15
ES2274973T3 (es) 2007-06-01
CA2444214A1 (en) 2002-10-31
US20040131545A1 (en) 2004-07-08
TWI245764B (en) 2005-12-21
WO2002085903A2 (en) 2002-10-31
US6696039B2 (en) 2004-02-24
USRE44338E1 (en) 2013-07-02
JP4317955B2 (ja) 2009-08-19
US7425318B2 (en) 2008-09-16

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