MX341316B - Poblacion de celulas madre neurales para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos. - Google Patents

Poblacion de celulas madre neurales para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos.

Info

Publication number
MX341316B
MX341316B MX2013001124A MX2013001124A MX341316B MX 341316 B MX341316 B MX 341316B MX 2013001124 A MX2013001124 A MX 2013001124A MX 2013001124 A MX2013001124 A MX 2013001124A MX 341316 B MX341316 B MX 341316B
Authority
MX
Mexico
Prior art keywords
methods
disorders
brain
treating
neurodegenerative diseases
Prior art date
Application number
MX2013001124A
Other languages
English (en)
Other versions
MX2013001124A (es
Inventor
Shyu Woei-Cherng
Lin Shinn-Zong
Wang Hsiao-Jung
K Johe Karl
Original Assignee
Neuralstem Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuralstem Inc * filed Critical Neuralstem Inc *
Publication of MX2013001124A publication Critical patent/MX2013001124A/es
Publication of MX341316B publication Critical patent/MX341316B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue

Abstract

La presente invención se refiere a métodos para el tratamiento de enfermedades/trastornos neurológicos utilizando células madre neurales (NSCs) obtenidas de un tejido de médula espinal. Los métodos pueden incluir el uso de una población de NSC para tratar una enfermedad/trastorno neurológico del cerebro. Dichos métodos pueden incluir introducir NSCs exógenamente cultivadas y expandidas en el cerebro, las cuales diferencian en neuronas capaces de integración in vivo en el tejido cerebral en una forma suficiente para mejorar los síntomas asociados con la enfermedad/ trastorno neurológico.
MX2013001124A 2010-07-28 2011-07-28 Poblacion de celulas madre neurales para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos. MX341316B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36840910P 2010-07-28 2010-07-28
PCT/US2011/045732 WO2012016049A1 (en) 2010-07-28 2011-07-28 Methods for treating and/or reversing neurodegenerative diseases and/or disorders

Publications (2)

Publication Number Publication Date
MX2013001124A MX2013001124A (es) 2013-08-01
MX341316B true MX341316B (es) 2016-08-15

Family

ID=44630526

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001124A MX341316B (es) 2010-07-28 2011-07-28 Poblacion de celulas madre neurales para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos.

Country Status (16)

Country Link
US (1) US9540611B2 (es)
EP (1) EP2598154B1 (es)
JP (2) JP6077996B2 (es)
KR (1) KR101765980B1 (es)
CN (1) CN103237553A (es)
AU (1) AU2011282642B2 (es)
CA (1) CA2806904C (es)
ES (1) ES2571991T3 (es)
IL (1) IL224416A (es)
MX (1) MX341316B (es)
MY (1) MY168084A (es)
NZ (2) NZ623207A (es)
RU (1) RU2013108868A (es)
SG (1) SG187226A1 (es)
WO (1) WO2012016049A1 (es)
ZA (1) ZA201300954B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101429284B1 (ko) * 2004-11-17 2014-08-11 뉴럴스템, 인크. 신경퇴행성 증상의 치료를 위한 인간 신경 세포의 이식
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
WO2014160387A2 (en) * 2013-03-14 2014-10-02 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US9072678B2 (en) 2013-03-14 2015-07-07 Pathak Holdings Llc Methods for local drug delivery by microinjection
WO2015006474A1 (en) * 2013-07-09 2015-01-15 Neuralstem, Inc. Methods of treating a subject with a cognitive dysfunction using spinal cord-derived neural stem cells
EP3161129B1 (en) * 2014-06-27 2019-08-07 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus e4orf1, and methods of making and using the same
CN108135839A (zh) * 2015-08-15 2018-06-08 阿斯特利亚斯生物治疗股份公司 用于治疗白质中风的干细胞衍生的少突胶质细胞祖细胞
CN106619722A (zh) * 2016-12-05 2017-05-10 上海安集协康生物技术股份有限公司 一种治疗脑部损伤类疾病的神经干细胞注射液
CN115089613A (zh) * 2022-07-25 2022-09-23 朗姿赛尔生物科技（广州）有限公司 一种神经干细胞移植在神经退行性疾病中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233838A3 (en) 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Neurite-promoting factor and process for the manufacture thereof
US4753635A (en) 1986-05-23 1988-06-28 Jacqueline Sagen Inducing analgesia by implantation of cells releasing neuroactive substances
NZ226750A (en) 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
WO1990001541A1 (en) 1988-08-04 1990-02-22 Amrad Corporation Limited In vitro propagation of embryonic stem cells
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US4980174A (en) 1988-12-23 1990-12-25 Jacqueline Sagen Method for alleviating depression
AU6174490A (en) 1989-08-04 1991-03-11 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
US5411883A (en) 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
WO1991009936A1 (en) 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
US5196315A (en) 1990-05-01 1993-03-23 The Johns Hopkins University Human neuronal cell line
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
AU665012B2 (en) 1991-07-08 1995-12-14 Neurospheres Holdings Ltd Novel growth factor-responsive progenitor cells which can be proliferated (in vitro)
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5175103A (en) 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
ATE178801T1 (de) 1991-11-22 1999-04-15 Genentech Inc Tgf-beta zur verbesserung der regeneration von neuronalem gewebe
US5672499A (en) 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
WO1994002593A1 (en) 1992-07-27 1994-02-03 California Institute Of Technology Mammalian multipotent neural stem cells
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
AU4995193A (en) 1992-08-04 1994-03-03 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
WO1994004675A2 (en) 1992-08-19 1994-03-03 Richard Kroczek Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family
ATE483795T1 (de) 1992-10-28 2010-10-15 Neurospheres Holdings Ltd Biologische faktoren und neuronale stammzellen
AU697894B2 (en) 1993-11-09 1998-10-22 Neurospheres Holdings Ltd (In situ) modification and manipulation of stem cells of the central nervous system
KR970706490A (ko) 1994-09-23 1997-11-03 스코트 디. 코르맥 중추신경계 기능 및 기능부전의 실험실 모델(in vitro models of cns function and dysfunction)
AU716811B2 (en) 1994-11-14 2000-03-09 Neurospheres Holdings Ltd Regulation of neural stem cell proliferation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5753505A (en) 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US5770414A (en) 1996-02-20 1998-06-23 The Regents Of The University Of California Regulatable retrovirus system for genetic modification of cells
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
AU7258098A (en) 1997-04-24 1998-11-13 California Institute Of Technology Methods for differentiating neural stem cells
IL133799A0 (en) 1997-07-04 2001-04-30 Univ Utah Res Found Lineage-restricted neuronal precursors
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US5932473A (en) 1997-09-30 1999-08-03 Becton Dickinson And Company Preparation of a cell culture substrate coated with poly-D-lysine
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
EP1115841B1 (en) 1998-09-22 2016-05-18 Neuralstem, Inc. Stable neural stem cell lines
US6284539B1 (en) 1998-10-09 2001-09-04 Neuralstem Biopharmaceuticals, Ltd. Method for generating dopaminergic cells derived from neural precursors
US6531464B1 (en) 1999-12-07 2003-03-11 Inotek Pharmaceutical Corporation Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
TWI245764B (en) 2001-04-23 2005-12-21 Hank F Kung Amyloid plaque aggregation inhibitors and diagnostic imaging agents
WO2003000852A2 (en) 2001-06-22 2003-01-03 The University Of Texas System Method of producing region-specific neurons from human neuronal stem cells
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
KR101429284B1 (ko) * 2004-11-17 2014-08-11 뉴럴스템, 인크. 신경퇴행성 증상의 치료를 위한 인간 신경 세포의 이식
US20120107284A1 (en) * 2006-06-30 2012-05-03 Elena Kozlova Stem cells for transplantation and methods for production thereof

Also Published As

Publication number Publication date
JP2013532690A (ja) 2013-08-19
CN103237553A (zh) 2013-08-07
SG187226A1 (en) 2013-03-28
ES2571991T3 (es) 2016-05-27
CA2806904A1 (en) 2012-02-02
NZ607195A (en) 2014-08-29
US9540611B2 (en) 2017-01-10
IL224416A (en) 2017-06-29
WO2012016049A1 (en) 2012-02-02
AU2011282642A1 (en) 2013-03-07
US20120177612A1 (en) 2012-07-12
CA2806904C (en) 2018-11-27
JP6077996B2 (ja) 2017-02-08
NZ623207A (en) 2014-12-24
JP2015214589A (ja) 2015-12-03
RU2013108868A (ru) 2014-09-10
KR20140048064A (ko) 2014-04-23
KR101765980B1 (ko) 2017-08-07
EP2598154B1 (en) 2016-03-23
AU2011282642B2 (en) 2015-06-11
MY168084A (en) 2018-10-11
MX2013001124A (es) 2013-08-01
ZA201300954B (en) 2014-04-30
EP2598154A1 (en) 2013-06-05

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