MX2012005131A - Enfoques terapeuticos nuevos para tratar la enfermedad de alzheimer. - Google Patents
Enfoques terapeuticos nuevos para tratar la enfermedad de alzheimer.Info
- Publication number
- MX2012005131A MX2012005131A MX2012005131A MX2012005131A MX2012005131A MX 2012005131 A MX2012005131 A MX 2012005131A MX 2012005131 A MX2012005131 A MX 2012005131A MX 2012005131 A MX2012005131 A MX 2012005131A MX 2012005131 A MX2012005131 A MX 2012005131A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- treating alzheimer
- alzheimer
- alzheimer disease
- new therapeutic
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 5
- 238000013459 approach Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000007960 cellular response to stress Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000890 drug combination Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere a composiciones y procedimientos para el tratamiento de la enfermedad de Alzheimer y trastornos relacionados. Más específicamente, la presente invención se refiere a terapias combinatorias novedosas de la enfermedad de Alzheimer y trastornos relacionados. En particular, la invención se refiere a compuestos que, en solitario o en combinación o combinaciones pueden modular eficazmente la función sináptica y/o la angiogénesis y/o la respuesta celular a estrés. La invención también se refiere a procedimientos para producir un fármaco o una combinación de fármacos para tratar la enfermedad de Alzheimer y a procedimientos para tratar la enfermedad de Alzheimer o un trastorno relacionado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09306048A EP2322163A1 (en) | 2009-11-03 | 2009-11-03 | New therapeutics approaches for treating alzheimer disease |
PCT/EP2010/066510 WO2011054759A1 (en) | 2009-11-03 | 2010-10-29 | New therapeutic approaches for treating alzheimer disease |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012005131A true MX2012005131A (es) | 2012-05-29 |
Family
ID=41693027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012005131A MX2012005131A (es) | 2009-11-03 | 2010-10-29 | Enfoques terapeuticos nuevos para tratar la enfermedad de alzheimer. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8809302B2 (es) |
EP (4) | EP2322163A1 (es) |
JP (2) | JP5977172B2 (es) |
CN (2) | CN107261144A (es) |
AR (1) | AR078846A1 (es) |
BR (1) | BR112012010470A2 (es) |
CA (2) | CA3065614A1 (es) |
EA (1) | EA024465B1 (es) |
ES (1) | ES2800311T3 (es) |
IL (1) | IL219412A (es) |
MX (1) | MX2012005131A (es) |
WO (1) | WO2011054759A1 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
EP2065038A1 (en) | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
NZ589304A (en) * | 2008-04-29 | 2012-03-30 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
EP2263665A1 (en) | 2009-06-02 | 2010-12-22 | Pharnext | New compositions for treating CMT and related disorders |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
PL3029039T3 (pl) | 2010-05-17 | 2018-04-30 | Forum Pharmaceuticals Inc. | Formulacje farmaceutyczne zawierające postacie krystaliczne jednowodnego chlorowodorku (R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidu |
KR101918745B1 (ko) | 2011-03-01 | 2018-11-15 | 파넥스트 | 바클로펜 및 아캄프로세이트에 기초한 신경 장애의 치료 |
US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
UA113165C2 (xx) | 2011-03-01 | 2016-12-26 | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
CN102861017A (zh) * | 2011-07-08 | 2013-01-09 | 辽宁省计划生育科学研究院 | 一种化合物在防治老年痴呆的应用 |
MX2014010481A (es) * | 2012-03-01 | 2015-03-20 | Pharnext | Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica. |
JP6158234B2 (ja) * | 2012-03-01 | 2017-07-05 | ファーネクストPharnext | 筋萎縮性側索硬化症の治療のための新規組成物 |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
EP2705841A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
JP6499077B2 (ja) * | 2012-10-25 | 2019-04-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
LT3003268T (lt) | 2013-06-05 | 2018-12-10 | Pharnext | Stabilūs peroraliniai tirpalai, skirti kompleksiniam aktyviam farmaciniam ingredientui (api) |
WO2015019125A1 (en) * | 2013-08-05 | 2015-02-12 | Societe De Developpement Et De Recherche Industrielle | Molecular targets for the treatment of wounds, in particular chronic wounds |
CN110305095A (zh) | 2013-10-22 | 2019-10-08 | 综合医院公司 | 色甘酸衍生物以及成像和治疗的相关方法 |
WO2015072700A1 (en) * | 2013-11-15 | 2015-05-21 | Hanmi Pharm. Co., Ltd. | Composite formulation comprising tadalafil and amlodipine |
KR101663238B1 (ko) * | 2013-11-15 | 2016-10-14 | 한미약품 주식회사 | 타다라필 및 암로디핀을 포함하는 복합 고형 제제 |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
CA2938361A1 (en) | 2014-02-11 | 2015-08-20 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
CN106604747A (zh) * | 2014-08-26 | 2017-04-26 | 基础应用医学研究基金会 | 用于治疗和预防伴随认知缺陷或缺损的神经障碍以及神经变性疾病的产品 |
GB2548740A (en) * | 2014-11-25 | 2017-09-27 | Harvard College | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same |
US10603311B2 (en) * | 2015-02-25 | 2020-03-31 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
US10520493B2 (en) * | 2015-03-13 | 2019-12-31 | National Cheng Kung University | Method for assessment of neural function by establishing analysis module |
CN104888198A (zh) * | 2015-04-21 | 2015-09-09 | 徐志强 | 降钙素在制造延缓脑老化药物的新用途 |
US11026942B2 (en) | 2015-12-29 | 2021-06-08 | Kyoto University | Agent for preventing and/or treating Alzheimer's disease |
US11433057B2 (en) | 2016-05-20 | 2022-09-06 | Vanda Pharmaceuticals Inc. | Method for improving or enhancing cognition |
JP7044768B2 (ja) | 2016-06-03 | 2022-03-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | プラダー・ウィリー症候群を治療する方法 |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
JP2019524865A (ja) | 2016-08-31 | 2019-09-05 | ザ ジェネラル ホスピタル コーポレイション | 神経変性疾患と関連する神経炎症におけるマクロファージ/ミクログリア |
KR101910153B1 (ko) * | 2016-11-04 | 2018-10-19 | 한국과학기술연구원 | 타우 관련 질환의 예방 또는 치료용 레보시멘단 화합물 |
CA3061243C (en) | 2017-04-24 | 2023-02-21 | Pharnext | Idalopirdine-based combinatorial therapies of alzheimer's disease |
WO2018213838A1 (en) * | 2017-05-19 | 2018-11-22 | Biscayne Neurotherapeutics, Inc. | Modified release pharmaceutical compositions of huperzine and methods of using the same |
AU2017423862A1 (en) | 2017-07-20 | 2020-02-06 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and ibuprofen |
US9962384B1 (en) * | 2017-09-07 | 2018-05-08 | Korea Institute Of Science And Technology | Levosimendan compound for preventing or treating tau-related diseases |
US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
JP7037814B2 (ja) * | 2018-03-28 | 2022-03-17 | 国立大学法人山口大学 | ホルボールエステルを有効成分とする軸索の伸展剤 |
JP2019182845A (ja) * | 2018-04-02 | 2019-10-24 | 学校法人藤田学園 | キヌレニンアミノトランスフェラーゼ2(kat2)阻害剤 |
WO2019216589A1 (ko) * | 2018-05-09 | 2019-11-14 | 한국과학기술연구원 | 타우 관련 질환의 예방 또는 치료용 조성물 |
KR102317080B1 (ko) * | 2018-05-09 | 2021-10-25 | 한국과학기술연구원 | 타우 관련 질환의 예방 또는 치료용 조성물 |
JP2021529771A (ja) | 2018-07-02 | 2021-11-04 | ザ ジェネラル ホスピタル コーポレイション | クロモリンナトリウムおよびα−ラクトースの粉末製剤 |
CN108707204B (zh) * | 2018-07-04 | 2020-09-15 | 吉林大学 | 过氧化氢响应型靶向载药纳米材料及制备方法 |
EP4025199A4 (en) * | 2019-07-12 | 2023-08-02 | University of South Florida | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
ES2821599A1 (es) * | 2019-10-24 | 2021-04-26 | Univ Del Pais Vasco / Euskal Herriko Unibertsitatea | Compuestos y metodos para el tratamiento de la enfermedad de alzheimer |
CN110656170A (zh) * | 2019-11-08 | 2020-01-07 | 新乡医学院 | 一种用于阿尔茨海默病诊断的试剂、诊断产品、治疗组合物,候选药物筛选方法及应用 |
WO2021142312A1 (en) * | 2020-01-10 | 2021-07-15 | The Board Of Regents Of The University Of Texas | Methods and compositions related to heparinoids |
CN115867277A (zh) * | 2020-06-19 | 2023-03-28 | 韩国科学技术研究院 | 新型稠合杂环基-碳腙酰二腈化合物及其用途 |
AR122680A1 (es) * | 2020-06-19 | 2022-09-28 | Korea Inst Sci & Tech | Nuevos compuestos de dicianuro de carbonohidrazonoilo que comprenden 2 o más grupos arilo o heteroarilo conectados por medio de un enlazador y uso de los mismos |
CN111983241B (zh) * | 2020-09-04 | 2022-05-20 | 四川大学华西医院 | 诊断脑卒中认知障碍的蛋白标志物以及模型的训练方法 |
CN114832116B (zh) * | 2022-05-19 | 2024-01-26 | 沈阳药科大学 | 基于小胶质细胞表型调节和脑内铁清除的ros响应型纳米载体及其制备方法与应用 |
CN115354048B (zh) * | 2022-06-08 | 2024-02-02 | 暨南大学 | 阿尔茨海默病动物模型的构建方法、用途和Aβ42重组表达载体 |
CN115851946B (zh) * | 2022-11-24 | 2023-09-01 | 中山大学孙逸仙纪念医院 | CaMK I作为治疗靶点在制备胰腺癌治疗药物中的应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2104594C (en) * | 1991-02-22 | 2004-05-11 | Howard K. Shapiro | Use of pharmaceutical compounds in the treatment of symptoms of disorders related to neurological diseases and etiologically related symptomology |
EP1262182A3 (en) * | 1991-11-26 | 2003-02-26 | Sepracor Inc. | Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine |
US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
US6573251B2 (en) * | 1994-03-30 | 2003-06-03 | Denis Barritault | Drug and pharmaceutical composition for the treatment of lesions of the nervous system and fractions enriched in heparan sulfate |
JPH101439A (ja) * | 1996-06-11 | 1998-01-06 | Mochida Pharmaceut Co Ltd | 神経変性疾患治療剤 |
US6391922B1 (en) | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
WO2001058476A2 (en) * | 2000-02-11 | 2001-08-16 | The European Molecular Biology Laboratory | Methods and compositions for treatment of alzheimer's disease by enhancing plasmin or plasmin-like activity |
GEP20063811B (en) * | 2001-07-19 | 2006-05-10 | Pharmacia Corp | Combination of Aldosterone Receptor Antagonist and HMG COA Reductase Inhibitor |
AU2003222009A1 (en) * | 2002-03-18 | 2003-10-08 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and nicotinic acid or a nicotinic acid derivative |
US20040102525A1 (en) * | 2002-05-22 | 2004-05-27 | Kozachuk Walter E. | Compositions and methods of treating neurological disease and providing neuroprotection |
EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
EP2465537B1 (en) * | 2002-10-10 | 2016-06-29 | ONO Pharmaceutical Co., Ltd. | Microspheres comprising ONO-1301 |
TWI323660B (en) * | 2003-02-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Pten inhibitor or maxi-k channels opener |
FI20040674A0 (fi) * | 2004-05-12 | 2004-05-12 | Orion Corp | Menetelmä tromboembolisten sairauksien estoon |
EP1837034A4 (en) * | 2004-11-30 | 2009-08-05 | Anges Mg Inc | MEDICATION FOR ALZHEIMER'S DISEASE |
US20080188510A1 (en) * | 2005-05-23 | 2008-08-07 | Eisai R & D Management Co., Ltd. | Novel methods using zonisamide |
CN101309682A (zh) * | 2005-10-21 | 2008-11-19 | 脑细胞股份有限公司 | 通过pde抑制调节神经发生 |
US20070112017A1 (en) * | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
KR101329112B1 (ko) * | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3r,5r)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
JP2009532663A (ja) * | 2006-02-16 | 2009-09-10 | レリアント ファーマスーティカルズ インコーポレイテッド | ω−3脂肪酸を用いた、痴呆、脳血管性痴呆、パーキンソン痴呆、アルツハイマー病及び/又は軽度認知障害の治療により利益を得ると考えられる患者を同定し、治療する方法 |
US20100029654A1 (en) * | 2006-03-23 | 2010-02-04 | Mount Sinai School Of Medicine | Cardiovascular compositions and use of the same for the treatment of alzheimer's disease |
US20090246170A1 (en) * | 2006-05-31 | 2009-10-01 | Dnavec Corporation | Therapeutic Agent For Alzheimer's Disease |
KR20090026275A (ko) * | 2006-07-06 | 2009-03-12 | 로스캄프 리서치 엘엘씨 | 베타-아밀로이드 생성을 억제하기 위한 화합물 및 그의 조합물, 및 그의 사용 방법 |
CA2657269A1 (en) * | 2006-07-17 | 2008-01-24 | Boehringer Ingelheim International Gmbh | New indications for direct thrombin inhibitors |
PL2157973T3 (pl) * | 2007-05-22 | 2015-12-31 | Otsuka Pharma Co Ltd | Lek zawierający pochodną karbostyrylu i donepezil do leczenia choroby Alzheimera |
JP5736098B2 (ja) * | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
US20100137442A2 (en) | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
MX2010011880A (es) * | 2008-04-29 | 2011-05-25 | Pharnext | Nuevos enfoques terapeuticos para tratar la enfermedad del alzheimer y trastornos relacionados mediante una modulacion de la respuesta de estres celular. |
CN102065898B (zh) * | 2008-04-29 | 2015-08-26 | 法奈科斯公司 | 通过调节血管发生治疗阿茨海默病和相关病症的新治疗手段 |
NZ589304A (en) * | 2008-04-29 | 2012-03-30 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
RU2489433C9 (ru) * | 2008-11-27 | 2014-06-10 | Нэшнл Юниверсити Корпорейшн Кагава Юниверсити | Производное циклобутилпурина, агент, активирующий ангиогенез, агент, активирующий образование просвета, агент, активирующий рост нейронов, и лекарственное средство |
EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
KR101918745B1 (ko) | 2011-03-01 | 2018-11-15 | 파넥스트 | 바클로펜 및 아캄프로세이트에 기초한 신경 장애의 치료 |
-
2009
- 2009-11-03 EP EP09306048A patent/EP2322163A1/en not_active Withdrawn
-
2010
- 2010-10-29 WO PCT/EP2010/066510 patent/WO2011054759A1/en active Application Filing
- 2010-10-29 CA CA3065614A patent/CA3065614A1/en not_active Abandoned
- 2010-10-29 EP EP10773302.4A patent/EP2496226B1/en active Active
- 2010-10-29 MX MX2012005131A patent/MX2012005131A/es active IP Right Grant
- 2010-10-29 ES ES10773302T patent/ES2800311T3/es active Active
- 2010-10-29 EA EA201200686A patent/EA024465B1/ru not_active IP Right Cessation
- 2010-10-29 EP EP19216647.8A patent/EP3650021A1/en not_active Withdrawn
- 2010-10-29 CA CA2779070A patent/CA2779070C/en active Active
- 2010-10-29 JP JP2012537355A patent/JP5977172B2/ja not_active Expired - Fee Related
- 2010-10-29 CN CN201710347219.2A patent/CN107261144A/zh active Pending
- 2010-10-29 BR BR112012010470A patent/BR112012010470A2/pt not_active Application Discontinuation
- 2010-10-29 EP EP20206600.7A patent/EP3797767A1/en not_active Withdrawn
- 2010-10-29 AR ARP100104015A patent/AR078846A1/es unknown
- 2010-10-29 CN CN2010800604548A patent/CN102834095A/zh active Pending
-
2012
- 2012-04-25 IL IL219412A patent/IL219412A/en active IP Right Grant
- 2012-05-02 US US13/462,034 patent/US8809302B2/en not_active Expired - Fee Related
-
2015
- 2015-04-27 JP JP2015090340A patent/JP6062995B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA024465B1 (ru) | 2016-09-30 |
CA2779070C (en) | 2020-02-25 |
ES2800311T3 (es) | 2020-12-29 |
EP2496226A1 (en) | 2012-09-12 |
EP2496226B1 (en) | 2020-03-04 |
WO2011054759A1 (en) | 2011-05-12 |
CN102834095A (zh) | 2012-12-19 |
EA201200686A1 (ru) | 2013-05-30 |
US20120270836A1 (en) | 2012-10-25 |
JP5977172B2 (ja) | 2016-08-24 |
IL219412A0 (en) | 2012-06-28 |
CN107261144A (zh) | 2017-10-20 |
AR078846A1 (es) | 2011-12-07 |
EP2322163A1 (en) | 2011-05-18 |
IL219412A (en) | 2017-05-29 |
JP2015157841A (ja) | 2015-09-03 |
CA3065614A1 (en) | 2011-05-12 |
EP3650021A1 (en) | 2020-05-13 |
CA2779070A1 (en) | 2011-05-12 |
EP3797767A1 (en) | 2021-03-31 |
BR112012010470A2 (pt) | 2016-03-08 |
JP6062995B2 (ja) | 2017-01-18 |
US8809302B2 (en) | 2014-08-19 |
JP2013510114A (ja) | 2013-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2012005131A (es) | Enfoques terapeuticos nuevos para tratar la enfermedad de alzheimer. | |
MX356865B (es) | Nuevas soluciones terapéuticas para tratar la enfermedad de parkinson. | |
EA201071245A1 (ru) | Новые терапевтические подходы для лечения болезни альцгеймера и связанных нарушений посредством модулирования реакции клеток на стресс | |
HRP20130345T1 (hr) | NOVI TERAPIJSKI PRISTUPI ZA LIJEČENJE CMT-a I SRODNIH POREMEĆA | |
NZ599830A (en) | Novel kinase modulators | |
MX2010004614A (es) | Composiciones para tratamiento del mal de parkinson. | |
AU2012277802A8 (en) | Novel inhibitor compounds of phosphodiesterase type 10A | |
MY156777A (en) | Substituted 2-acetamido-5-ary1-1,2,4-triazolones and use thereof | |
EA201071243A1 (ru) | Комбинированные композиции для лечения болезни альцгеймера и родственных заболеваний зонизамидом и акампросатом | |
TW201144302A (en) | 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds | |
HK1154587A1 (en) | Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators | |
AU2011328009A8 (en) | Compounds and methods for treating pain | |
MY173994A (en) | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same | |
EA201590655A8 (ru) | Комбинация лахинимода и придопидина для лечения нейродегенеративных нарушений | |
WO2013061161A3 (en) | New combination therapies for treating neurological disorders | |
MX2009013990A (es) | Metodos para tratar enfermedades y trastornos mediados por serotonina. | |
MX2013011908A (es) | Composiciones y usos terapeuticos de inhibidores de cinasa epsilon relacionados con cinasa i-kappa b (ikk) y cinasa 1 de union tank. | |
TN2010000122A1 (en) | Compounds and compositions as modulators of gpr119 activity | |
WO2011115725A3 (en) | Indazole compounds as kinase activity modulators for the treatment of cancer and related disorders | |
EA201200002A1 (ru) | Производные индоламида и родственные соединения для использования при лечении нейродегенеративных заболеваний | |
MX2012002583A (es) | Moduladores de piranil aril metil benzoquinazolinona alostericos positivos del receptor m1. | |
MX2012004078A (es) | Compuestos y composiciones como moduladores de la actividad de gpr119. | |
UA101393C2 (ru) | КОМПОЗИЦИИ И ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ ТРИАЗОЛА ДЛЯ ЛЕЧЕНИЯ β-АМИЛОИДОЗОВ И СИНУКЛЕИНОПАТИЙ | |
TW200735868A (en) | Compositions and methods for treating CNS disorders | |
UA102515C2 (ru) | Новая лекарственная форма |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |