MX2014010481A - Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica. - Google Patents

Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica.

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Publication number
MX2014010481A
MX2014010481A MX2014010481A MX2014010481A MX2014010481A MX 2014010481 A MX2014010481 A MX 2014010481A MX 2014010481 A MX2014010481 A MX 2014010481A MX 2014010481 A MX2014010481 A MX 2014010481A MX 2014010481 A MX2014010481 A MX 2014010481A
Authority
MX
Mexico
Prior art keywords
lateral sclerosis
amyotrophic lateral
new compositions
treating amyotrophic
treatment
Prior art date
Application number
MX2014010481A
Other languages
English (en)
Other versions
MX373763B (es
Inventor
Daniel Cohen
Ilya Chumakov
Serguei Nabirochkin
Rodolphe Hajj
Original Assignee
Pharnext
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/053570 external-priority patent/WO2012117076A2/en
Application filed by Pharnext filed Critical Pharnext
Publication of MX2014010481A publication Critical patent/MX2014010481A/es
Publication of MX373763B publication Critical patent/MX373763B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a composiciones y métodos para el tratamiento de la esclerosis lateral amiotrófica. Más específicamente, la presente invención se refiere a nuevas terapias de combinación para el tratamiento de la esclerosis lateral amiotrófica o un trastorno relacionado.
MX2014010481A 2011-03-01 2013-02-28 Uso de una composición de combinación de acamprosato y baclofeno de liberación sostenida, para el tratamiento de esclerosis lateral amiotrófica. MX373763B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11305217 2011-03-01
PCT/EP2012/053570 WO2012117076A2 (en) 2011-03-01 2012-03-01 Baclofen and acamprosate based therapy of neurogical disorders
PCT/EP2012/053565 WO2012117073A2 (en) 2011-03-01 2012-03-01 New compositions for treating neurological disorders
PCT/EP2013/054024 WO2013127917A1 (en) 2011-03-01 2013-02-28 New compositions for treating amyotrophic lateral sclerosis

Publications (2)

Publication Number Publication Date
MX2014010481A true MX2014010481A (es) 2015-03-20
MX373763B MX373763B (es) 2020-03-24

Family

ID=44124101

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2013010044A MX360871B (es) 2011-03-01 2012-03-01 Nuevas composiciones para tratar trastornos neurológicos.
MX2014010481A MX373763B (es) 2011-03-01 2013-02-28 Uso de una composición de combinación de acamprosato y baclofeno de liberación sostenida, para el tratamiento de esclerosis lateral amiotrófica.
MX2019011905A MX2019011905A (es) 2011-03-01 2014-09-02 Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2013010044A MX360871B (es) 2011-03-01 2012-03-01 Nuevas composiciones para tratar trastornos neurológicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011905A MX2019011905A (es) 2011-03-01 2014-09-02 Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica.

Country Status (17)

Country Link
EP (1) EP2680836B1 (es)
JP (1) JP6328428B2 (es)
KR (2) KR101918669B1 (es)
CN (2) CN103608007A (es)
AU (1) AU2012222348B2 (es)
BR (1) BR112013022102A2 (es)
CA (1) CA2828763C (es)
DK (1) DK2819664T3 (es)
EA (1) EA032881B1 (es)
ES (2) ES2690490T3 (es)
HK (2) HK1245650A1 (es)
IL (2) IL228176A (es)
MX (3) MX360871B (es)
SG (2) SG192970A1 (es)
UA (2) UA115968C2 (es)
WO (2) WO2012117073A2 (es)
ZA (2) ZA201306038B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2646045B1 (en) * 2010-12-02 2017-07-05 Massachusetts Institute of Technology Suppressors of neurotoxicity in huntington's disease
RS57426B1 (sr) 2011-03-01 2018-09-28 Pharnext Terapija neuroloških poremećaja kombinacijom baklofena i akamprosata
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
UA115968C2 (uk) * 2011-03-01 2018-01-25 Фарнекст Нові композиції для лікування неврологічних захворювань
EP2705842A1 (en) 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating parkinson's disease
US9867837B2 (en) * 2011-03-01 2018-01-16 Pharnext Compositions for treating neurological disorders
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US9931326B2 (en) 2011-03-29 2018-04-03 Pharnext Composition comprising torasemide and baclofen for treating neurological disorders
AU2013224959B2 (en) * 2012-03-01 2017-12-07 Pharnext New compositions for treating amyotrophic lateral sclerosis
PT2819664T (pt) * 2012-03-01 2017-08-24 Pharnext Novas composições para tratar esclerose lateral amiotrófica
EP2705843A1 (en) * 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis
EP2705841A1 (en) * 2012-09-05 2014-03-12 Pharnext Combinations of nootropic agents for treating cognitive dysfunctions
EP2727587A1 (en) * 2012-10-30 2014-05-07 Pharnext Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
US20160038521A1 (en) * 2013-03-15 2016-02-11 University Of Iowa Research Foundation Therapeutic methods
BR112015031835B1 (pt) 2013-06-19 2022-12-13 Som Innovation Biotech, S.L Usos de agentes terapêuticos, de uma combinação dos referidos agentes com um agente terapêutico adicional, e de uma composição farmacêutica para fabricação de medicamento para a profilaxia e/ou tratamento de distúrbios do movimento hipercinético
AU2014352920A1 (en) * 2013-11-22 2016-06-23 Genzyme Corporation Novel methods for treating neurodegenerative diseases
EP3104850A1 (en) 2014-02-11 2016-12-21 Pharnext Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders
JP6688295B2 (ja) * 2014-10-15 2020-04-28 オリオン コーポレーション 運動ニューロン病（例えばａｌｓ）の治療における使用のためのレボシメンダン
LT3220891T (lt) 2014-11-21 2019-11-11 Biohaven Therapeutics Ltd Poliežuvinė riluzolio kompozicija
WO2017115873A1 (ja) * 2015-12-29 2017-07-06 国立大学法人京都大学 アルツハイマー病の予防及び／又は治療剤
CN109069450A (zh) * 2016-02-05 2018-12-21 法奈克斯公司 神经障碍的新的组合疗法
WO2019004321A1 (ja) 2017-06-28 2019-01-03 国立大学法人京都大学 アルツハイマー病の予防及び／又は治療剤
US10322114B2 (en) * 2017-07-31 2019-06-18 Above And Beyond Nb, Llc Formulation of a riluzole solution with beta-cyclodextrins
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
AU2018310882C1 (en) 2017-07-31 2021-12-09 Novartis Ag Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use
CA3088715A1 (en) * 2018-01-29 2019-08-01 Pharnext Baclofen and acamprosate based therapy of alzheimer's disease in patients having lost responsiveness to acetylcholinesterase inhibitor therapy
KR20200121495A (ko) 2019-04-16 2020-10-26 동아대학교 산학협력단 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
CN114555066A (zh) * 2019-07-12 2022-05-27 南佛罗里达大学 用于治疗阿尔茨海默病的组合物和方法
JPWO2022054927A1 (es) * 2020-09-11 2022-03-17
JP2023155212A (ja) * 2022-04-07 2023-10-20 ミトス セラピューティクス インコーポレーティッド スルホンアミド系化合物を含む筋肉疾患改善、治療または予防用組成物
KR102866848B1 (ko) * 2022-04-07 2025-10-02 주식회사 미토스테라퓨틱스 설폰아미드계 화합물을 포함하는 근육질환 개선, 치료 또는 예방용 조성물
CN117323305B (zh) * 2023-11-07 2024-06-07 杭州沐源生物医药科技有限公司 溴隐亭片剂及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742054A (en) * 1982-11-23 1988-05-03 Naftchi Nosrat E Treatment of mammals suffering from damage to the central nervous system
CA2044853C (en) * 1990-07-19 2004-11-09 Susan A. Greenfield Method for treating parkinson's disease employing an atp-sensitive potassium channel blocker
DE4113820A1 (de) * 1991-04-27 1992-10-29 Boehringer Mannheim Gmbh Verwendung von torasemid zur behandlung von hirnoedemen
US5486530A (en) * 1991-04-27 1996-01-23 Boehringer Mannheim Gmbh Use of torasemide for the treatment of brain oedemas
FR2722989B1 (fr) * 1994-07-29 1997-05-30 Synthelabo Utilisation de l'ifenprodil et de ses enantiomeres pour la preparation de medicaments utiles dans le traitement des neuropathies peripheriques et des maladies neurodegeneratives centrales
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
US8980952B2 (en) * 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
KR101140559B1 (ko) 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
CA2551859C (en) 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
CN101365451A (zh) * 2005-11-21 2009-02-11 阿拉巴马大学董事会 使用小分子化合物用于神经保护的方法
US20100056444A1 (en) * 2006-10-12 2010-03-04 Sven Martin Jacobson Treatment of Alzheimer's Disease Using Compounds that Reduce the Activity of Non Selective Ca Activated ATP- Sensitive Cation Channels Regulated by SUR1 Receptors
WO2008086492A1 (en) 2007-01-11 2008-07-17 Xenoport, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
US20100178293A1 (en) * 2007-06-22 2010-07-15 Olaf Weber Use of antibodies against the cd52 antigen for the treatment of neurological disorders, particularly transmissible spongiform encephalopathy and alzheimer's disease
US20090069419A1 (en) 2007-09-07 2009-03-12 Bernd Jandeleit Masked carboxylate neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US20090082464A1 (en) 2007-09-07 2009-03-26 Bernd Jandeleit Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
WO2009052191A1 (en) 2007-10-15 2009-04-23 Xenoport, Inc. Internally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
TW200936123A (en) 2007-11-06 2009-09-01 Xenoport Inc Use of prodrugs of GABAb agonists for treating neuropathic and musculoskeletal pain
EP2065038A1 (en) 2007-11-30 2009-06-03 Pharnext New therapeutic approaches for treating Charcot-Marie-Tooth disease
WO2009096985A1 (en) 2008-02-01 2009-08-06 Xenoport, Inc. Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment
US20100137442A2 (en) 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
WO2009133128A1 (en) * 2008-04-29 2009-11-05 Pharnext Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate
EP2282779B1 (en) * 2008-04-29 2013-03-13 Pharnext New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response
JP5721230B2 (ja) * 2008-04-29 2015-05-20 ファーネクストＰｈａｒｎｅｘｔ 血管新生の調節を通したアルツハイマー病および関連障害の処置のための新たな治療アプローチ
EP2135607A1 (en) 2008-06-18 2009-12-23 Pharnext Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders
CN102341380A (zh) * 2009-01-22 2012-02-01 神经病治疗药物股份有限公司 布美他尼、呋塞米、吡咯他尼、佐塞米和托拉塞米类似物、组合物和使用方法
CA2753057C (en) 2009-03-03 2018-09-11 Xenoport, Inc. Sustained release oral dosage forms of an r-baclofen prodrug
WO2010120370A2 (en) 2009-04-17 2010-10-21 Xenoport, Inc. Gamma-amino-butyric acid derivatives as gabab receptor ligands
EP2593104A4 (en) * 2009-07-24 2014-02-05 Mueller Prof Dr Wolfgang PROCESS FOR TREATING AND PREVENTING / REDUCING THE PROBABILITY OF MESIAL TEMPORARY PEPPER (TLE)
CN101632665B (zh) * 2009-09-01 2011-08-17 严洁 一种托拉塞米口服药物组合物
EP2322163A1 (en) 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
RS57426B1 (sr) * 2011-03-01 2018-09-28 Pharnext Terapija neuroloških poremećaja kombinacijom baklofena i akamprosata
UA115968C2 (uk) * 2011-03-01 2018-01-25 Фарнекст Нові композиції для лікування неврологічних захворювань

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