MX360871B - Nuevas composiciones para tratar trastornos neurológicos. - Google Patents
Nuevas composiciones para tratar trastornos neurológicos.Info
- Publication number
- MX360871B MX360871B MX2013010044A MX2013010044A MX360871B MX 360871 B MX360871 B MX 360871B MX 2013010044 A MX2013010044 A MX 2013010044A MX 2013010044 A MX2013010044 A MX 2013010044A MX 360871 B MX360871 B MX 360871B
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- neurological disorders
- alzheimer
- new compositions
- treating neurological
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 abstract 1
- UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 abstract 1
- 208000003130 Alcoholic Neuropathy Diseases 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 230000006974 Aβ toxicity Effects 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 abstract 1
- UHWVSEOVJBQKBE-UHFFFAOYSA-N Trimetazidine Chemical compound COC1=C(OC)C(OC)=CC=C1CN1CCNCC1 UHWVSEOVJBQKBE-UHFFFAOYSA-N 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
- 208000020701 alcoholic polyneuropathy Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 abstract 1
- 229960002802 bromocriptine Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000003492 excitotoxic effect Effects 0.000 abstract 1
- 231100000063 excitotoxicity Toxicity 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 229960003998 ifenprodil Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960003404 mexiletine Drugs 0.000 abstract 1
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 abstract 1
- 229960003702 moxifloxacin Drugs 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960005461 torasemide Drugs 0.000 abstract 1
- 229960001177 trimetazidine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a composiciones y procedimientos para el tratamiento de trastornos neurológicos relacionados con la excitotoxicidad por glutamato y la toxicidad por 3 amiloides. Más específicamente, la presente invención se refiere a nuevas terapias de combinación de esclerosis múltiple, enfermedad de Alzheimer, trastornos relacionados con la enfermedad de Alzheimer, esclerosis lateral amiotrófica, enfermedad de parkinson, enfermedad de Huntington, dolor neuropático, neuropatía alcohólica, alcoholismo o síndrome de abstinencia por alcohol, o lesión de la médula espinal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11305217 | 2011-03-01 | ||
US201161468658P | 2011-03-29 | 2011-03-29 | |
PCT/EP2012/053565 WO2012117073A2 (en) | 2011-03-01 | 2012-03-01 | New compositions for treating neurological disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013010044A MX2013010044A (es) | 2014-02-17 |
MX360871B true MX360871B (es) | 2018-11-16 |
Family
ID=44124101
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010044A MX360871B (es) | 2011-03-01 | 2012-03-01 | Nuevas composiciones para tratar trastornos neurológicos. |
MX2019011905A MX2019011905A (es) | 2011-03-01 | 2014-09-02 | Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019011905A MX2019011905A (es) | 2011-03-01 | 2014-09-02 | Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2680836B1 (es) |
JP (1) | JP6328428B2 (es) |
KR (2) | KR101918669B1 (es) |
CN (2) | CN108420819A (es) |
AU (1) | AU2012222348B2 (es) |
BR (1) | BR112013022102A2 (es) |
CA (1) | CA2828763C (es) |
DK (1) | DK2819664T3 (es) |
EA (1) | EA032881B1 (es) |
ES (2) | ES2690490T3 (es) |
HK (2) | HK1245650A1 (es) |
IL (2) | IL228176A (es) |
MX (2) | MX360871B (es) |
SG (2) | SG192970A1 (es) |
UA (2) | UA113165C2 (es) |
WO (2) | WO2012117073A2 (es) |
ZA (2) | ZA201306038B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011336346B2 (en) * | 2010-12-02 | 2015-06-18 | Massachusetts Institute Of Technology | Chemical and RNAi suppressors of neurotoxicity in Huntington's Disease |
EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
UA113165C2 (xx) * | 2011-03-01 | 2016-12-26 | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
US9867837B2 (en) * | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
CN103596562B (zh) | 2011-03-01 | 2016-06-01 | 法耐斯特公司 | 基于巴氯芬和阿坎酸的神经性障碍疗法 |
US9931326B2 (en) | 2011-03-29 | 2018-04-03 | Pharnext | Composition comprising torasemide and baclofen for treating neurological disorders |
PT2819664T (pt) * | 2012-03-01 | 2017-08-24 | Pharnext | Novas composições para tratar esclerose lateral amiotrófica |
MX2014010481A (es) * | 2012-03-01 | 2015-03-20 | Pharnext | Nuevas composiciones para el tratamiento de la esclerosis lateral amiotrofica. |
EP2705843A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
EP2705841A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
EP2727587A1 (en) * | 2012-10-30 | 2014-05-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
EP2996684A4 (en) * | 2013-03-15 | 2016-11-30 | Univ Iowa Res Found | THERAPEUTIC PROCEDURES |
CA2915811C (en) | 2013-06-19 | 2021-08-31 | Som Innovation Biotech, S.L. | Therapeutic agents for use in the prophylaxis and/or treatment of hyperkinetic movement disorders |
JP2016537360A (ja) * | 2013-11-22 | 2016-12-01 | ジェンザイム・コーポレーション | 神経変性疾患を治療するための新規な方法 |
WO2015121218A1 (en) | 2014-02-11 | 2015-08-20 | Pharnext | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
US10357492B2 (en) | 2014-10-15 | 2019-07-23 | Orion Corporation | Levosimendan for use in the treatment of motor neuron diseases (E.G. ALS) |
ES2882783T3 (es) * | 2014-11-21 | 2021-12-02 | Biohaven Pharm Holding Co Ltd | Formulación sublingual de riluzol |
JP6879560B2 (ja) * | 2015-12-29 | 2021-06-02 | 国立大学法人京都大学 | アルツハイマー病の予防及び/又は治療剤 |
CA3012900A1 (en) * | 2016-02-05 | 2017-08-10 | Pharnext | Novel combinatorial therapies of neurological disorders |
CA3068575A1 (en) * | 2017-06-28 | 2019-01-03 | Kyoto University | Agent for preventing and/or treating alzheimer's disease |
US11878001B2 (en) | 2017-07-31 | 2024-01-23 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
US10322114B2 (en) * | 2017-07-31 | 2019-06-18 | Above And Beyond Nb, Llc | Formulation of a riluzole solution with beta-cyclodextrins |
JP2021512174A (ja) * | 2018-01-29 | 2021-05-13 | ファーネクストPharnext | アセチルコリンエステラーゼ阻害剤療法に対する反応性を失った患者におけるアルツハイマー病のバクロフェン及びアカンプロセートを用いた療法 |
KR20200121495A (ko) | 2019-04-16 | 2020-10-26 | 동아대학교 산학협력단 | 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 |
CN114555066A (zh) * | 2019-07-12 | 2022-05-27 | 南佛罗里达大学 | 用于治疗阿尔茨海默病的组合物和方法 |
WO2022054927A1 (ja) * | 2020-09-11 | 2022-03-17 | 国立大学法人大阪大学 | オートファジーを活性化するための組成物 |
EP4257139A3 (en) * | 2022-04-07 | 2023-12-13 | Mitos Therapeutics Inc. | Composition for improving, preventing or treating muscular disorders comprising sulfonamide-based compounds |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4742054A (en) * | 1982-11-23 | 1988-05-03 | Naftchi Nosrat E | Treatment of mammals suffering from damage to the central nervous system |
CA2044853C (en) * | 1990-07-19 | 2004-11-09 | Susan A. Greenfield | Method for treating parkinson's disease employing an atp-sensitive potassium channel blocker |
US5486530A (en) * | 1991-04-27 | 1996-01-23 | Boehringer Mannheim Gmbh | Use of torasemide for the treatment of brain oedemas |
DE4113820A1 (de) * | 1991-04-27 | 1992-10-29 | Boehringer Mannheim Gmbh | Verwendung von torasemid zur behandlung von hirnoedemen |
FR2722989B1 (fr) * | 1994-07-29 | 1997-05-30 | Synthelabo | Utilisation de l'ifenprodil et de ses enantiomeres pour la preparation de medicaments utiles dans le traitement des neuropathies peripheriques et des maladies neurodegeneratives centrales |
EP1485082A4 (en) | 2002-02-19 | 2009-12-30 | Xenoport Inc | PROCESS FOR THE SYNTHESIS OF PROMEDICAMENTS FROM 1-ACYL-ALKYL DERIVATIVES AND CORRESPONDING COMPOSITIONS |
US8980952B2 (en) * | 2002-03-20 | 2015-03-17 | University Of Maryland, Baltimore | Methods for treating brain swelling with a compound that blocks a non-selective cation channel |
BRPI0413756A (pt) | 2003-08-20 | 2006-10-31 | Xenoport Inc | composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica |
CN102702065A (zh) | 2003-12-30 | 2012-10-03 | 什诺波特有限公司 | 酰氧基烃基氨基甲酸酯前药及其中间体的合成 |
CN101365451A (zh) * | 2005-11-21 | 2009-02-11 | 阿拉巴马大学董事会 | 使用小分子化合物用于神经保护的方法 |
WO2008046014A1 (en) * | 2006-10-12 | 2008-04-17 | Remedy Pharmaceuticals, Inc. | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors |
EP2117517B1 (en) | 2007-01-11 | 2011-06-01 | XenoPort, Inc. | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
US20100178293A1 (en) * | 2007-06-22 | 2010-07-15 | Olaf Weber | Use of antibodies against the cd52 antigen for the treatment of neurological disorders, particularly transmissible spongiform encephalopathy and alzheimer's disease |
US20090069419A1 (en) | 2007-09-07 | 2009-03-12 | Bernd Jandeleit | Masked carboxylate neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
US20090082464A1 (en) | 2007-09-07 | 2009-03-26 | Bernd Jandeleit | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
TW200932734A (en) | 2007-10-15 | 2009-08-01 | Xenoport Inc | Internally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
TW200936123A (en) | 2007-11-06 | 2009-09-01 | Xenoport Inc | Use of prodrugs of GABAb agonists for treating neuropathic and musculoskeletal pain |
EP2065038A1 (en) | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
US20100137442A2 (en) | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
WO2009096985A1 (en) | 2008-02-01 | 2009-08-06 | Xenoport, Inc. | Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment |
CA2722453C (en) * | 2008-04-29 | 2018-03-20 | Pharnext | New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of angiogenesis |
EA019571B1 (ru) * | 2008-04-29 | 2014-04-30 | Фарнекст | Применение сульфизоксазола для лечения болезни альцгеймера |
EP3560496A1 (en) * | 2008-04-29 | 2019-10-30 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
MX2011007759A (es) * | 2009-01-22 | 2011-10-11 | Neurotherapeutics Pharma Inc | Analogos de bumetanida, furosemida, piretanida, azosemida y torsemida, composiciones y metodos de uso. |
WO2010102071A1 (en) | 2009-03-03 | 2010-09-10 | Xenoport, Inc. | Sustained release oral dosage forms of an r-baclofen prodrug |
WO2010120370A2 (en) | 2009-04-17 | 2010-10-21 | Xenoport, Inc. | Gamma-amino-butyric acid derivatives as gabab receptor ligands |
US10238622B2 (en) * | 2009-07-24 | 2019-03-26 | Wolfgang S. Mueller | Methods of treating and preventing/reducing the likelihood of Mesial temporal lobe epilepsy (TLE) |
CN101632665B (zh) * | 2009-09-01 | 2011-08-17 | 严洁 | 一种托拉塞米口服药物组合物 |
EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
UA113165C2 (xx) * | 2011-03-01 | 2016-12-26 | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
CN103596562B (zh) * | 2011-03-01 | 2016-06-01 | 法耐斯特公司 | 基于巴氯芬和阿坎酸的神经性障碍疗法 |
-
2012
- 2012-01-03 UA UAA201311478A patent/UA113165C2/uk unknown
- 2012-01-03 UA UAA201311479A patent/UA115968C2/uk unknown
- 2012-03-01 MX MX2013010044A patent/MX360871B/es active IP Right Grant
- 2012-03-01 WO PCT/EP2012/053565 patent/WO2012117073A2/en active Application Filing
- 2012-03-01 ES ES12707741.0T patent/ES2690490T3/es active Active
- 2012-03-01 EA EA201300975A patent/EA032881B1/ru not_active IP Right Cessation
- 2012-03-01 AU AU2012222348A patent/AU2012222348B2/en not_active Ceased
- 2012-03-01 BR BR112013022102A patent/BR112013022102A2/pt not_active Application Discontinuation
- 2012-03-01 EP EP12707741.0A patent/EP2680836B1/en not_active Not-in-force
- 2012-03-01 JP JP2013555880A patent/JP6328428B2/ja not_active Expired - Fee Related
- 2012-03-01 KR KR1020137026005A patent/KR101918669B1/ko active IP Right Grant
- 2012-03-01 SG SG2013064852A patent/SG192970A1/en unknown
- 2012-03-01 CN CN201810211981.2A patent/CN108420819A/zh active Pending
- 2012-03-01 CA CA2828763A patent/CA2828763C/en not_active Expired - Fee Related
- 2012-03-01 CN CN201280017652.5A patent/CN103608007A/zh active Pending
-
2013
- 2013-02-28 WO PCT/EP2013/054024 patent/WO2013127917A1/en active Application Filing
- 2013-02-28 ES ES13706548.8T patent/ES2635872T3/es active Active
- 2013-02-28 SG SG11201405336VA patent/SG11201405336VA/en unknown
- 2013-02-28 KR KR1020147027807A patent/KR102014883B1/ko active IP Right Grant
- 2013-02-28 DK DK13706548.8T patent/DK2819664T3/en active
- 2013-08-12 ZA ZA2013/06038A patent/ZA201306038B/en unknown
- 2013-08-29 IL IL228176A patent/IL228176A/en active IP Right Grant
-
2014
- 2014-08-07 IL IL234023A patent/IL234023B/en active IP Right Grant
- 2014-09-02 MX MX2019011905A patent/MX2019011905A/es unknown
- 2014-09-22 ZA ZA2014/06913A patent/ZA201406913B/en unknown
-
2015
- 2015-04-29 HK HK18105132.8A patent/HK1245650A1/zh unknown
- 2015-04-29 HK HK19100582.3A patent/HK1258223A1/zh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX360871B (es) | Nuevas composiciones para tratar trastornos neurológicos. | |
MX2016002644A (es) | Composicion que comprende torasemida y baclofeno para tratar trastornos neurologicos. | |
MX340568B (es) | Terapia para transtornos neurologicos a base de baclofeno y acampros ato. | |
HK1258231A1 (zh) | 治療阿爾茨海默氏症、亨廷頓氏症、孤獨症和其他障礙的方法 | |
PH12018502101A1 (en) | Heterocyclic compound | |
PH12018500087A1 (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors | |
NZ700374A (en) | New therapeutic approaches for treating parkinson’s disease | |
IN2014DN05772A (es) | ||
CY1120148T1 (el) | Ενωσεις ουριας και η χρηση τους ως ενζυμικοι αναστολεις | |
MX2013011589A (es) | Metodos y composiciones para tratar enfermedad de parkinson. | |
WO2015011284A3 (en) | Inhibitors of fapp2 and uses thereof | |
TN2014000058A1 (en) | A Novel 1,2,3,4-Tetrahydroquinoline Derivative Useful for the Treatment of Diabetes | |
GB201103103D0 (en) | Organic compounds | |
MX2016008842A (es) | Derivados de n-fenil-lactama capaces de estimular la neurogenesis y su uso en el tratamiento de trastornos neurologicos. | |
MX2015015052A (es) | Derivados de isoquinolina que estimulan la neurogenesis. | |
MX362532B (es) | Derivados de 1,7-naftiridina. | |
EP2542085A4 (en) | COMPOUNDS FOR THE TREATMENT OF NEURODEEGENERATIVE DISORDER | |
WO2010083241A3 (en) | 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders | |
PH12014502780A1 (en) | Azetidine and piperidine compounds useful as pde10 inhibitors | |
AU2019268209A1 (en) | Compounds for the treatment of seizures and other central nervous system disorders and conditions | |
WO2011021832A3 (ko) | 척수 손상 예방 또는 치료용 조성물 | |
IL232627A0 (en) | A method for the creation of methoxypropanamides converted at nitrogen in 2(acetylamino)-n-benzyl-3 | |
WO2014006528A3 (en) | Compositions and methods for the treatment of neurological degenerative disorders | |
WO2012121862A3 (en) | Valproic acid derivative compounds | |
WO2014073994A3 (en) | New alkanolamide derivatives of cinnamic acid and use of alkanolamide derivatives of cinnamic acid for preparation of drugs |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |