CY1120148T1 - Ενωσεις ουριας και η χρηση τους ως ενζυμικοι αναστολεις - Google Patents

Ενωσεις ουριας και η χρηση τους ως ενζυμικοι αναστολεις

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Publication number
CY1120148T1
CY1120148T1 CY20181100426T CY181100426T CY1120148T1 CY 1120148 T1 CY1120148 T1 CY 1120148T1 CY 20181100426 T CY20181100426 T CY 20181100426T CY 181100426 T CY181100426 T CY 181100426T CY 1120148 T1 CY1120148 T1 CY 1120148T1
Authority
CY
Cyprus
Prior art keywords
neurotoxicity
insomnia
disease
alcohol
compound
Prior art date
Application number
CY20181100426T
Other languages
English (en)
Inventor
Carla Patrícia da Costa Pereira ROSA
Rita GUSMÃO DE NORONHA
Laszlo Erno Kiss
Patrício Manuel Vieira Araújo SOARES DA SILVA
Domenico Russo
Jorge Bruno Reis Wahnon
William MATON
Original Assignee
Bial-Portela & Ca, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial-Portela & Ca, S.A. filed Critical Bial-Portela & Ca, S.A.
Publication of CY1120148T1 publication Critical patent/CY1120148T1/el

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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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Abstract

Μια ένωση με την παρακάτω δομή, ή ένα φαρμακευτικώς αποδεκτό άλας ή παράγωγο αυτής. Η ένωση μπορεί να χρησιμοποιηθεί για τη θεραπεία ή πρόληψη μιας διαταραχής που επιλέγεται από ρύθμιση της όρεξης, παχυσαρκία, μεταβολικές διαταραχές, καχεξία, ανορεξία, πόνο, φλεγμονή, νευροτοξικότητα, νευροτραυματισμό, εγκεφαλικό επεισόδιο, πολλαπλή σκλήρυνση, τραυματισμό της σπονδυλικής στήλης, ασθένεια Parkinson, δυσκινησία που προκαλείται από λεβοντόπα, ασθένεια Huntington, σύνδρομο Gilles de la Tourette, όψιμη δυσκινησία, δυστονία, αμυοτροφική πλευρική σκλήρυνση, ασθένεια Alzheimer, επιληψία, σχιζοφρένεια, άγχος, κατάθλιψη, αϋπνία, ναυτία, εμετό, διαταραχές οινοπνεύματος, εξαρτήσεις από φάρμακα όπως οπιοειδή, νικοτίνη, κοκαΐνη, οινόπνευμα και ψυχοδιεγερτικά, υπέρταση, κυκλοφορικό σοκ, μυοκαρδιακή βλάβη από επαναιμάτωση, αθηροσκλήρυνση, άσθμα, γλαύκωμα, αμφιβληστροειδοπάθεια, καρκίνο, φλεγμονώδη εντεροπάθεια, οξεία και χρόνια ηπατοπάθεια όπως ηπατίτιδα και ηπατική κίρρωση, αρθρίτιδα και οστεοπόρωση.
CY20181100426T 2012-07-24 2018-04-23 Ενωσεις ουριας και η χρηση τους ως ενζυμικοι αναστολεις CY1120148T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261674970P 2012-07-24 2012-07-24
PCT/PT2013/000048 WO2014017936A2 (en) 2012-07-24 2013-07-24 Urea compounds and their use as enzyme inhibitors

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CY1120148T1 true CY1120148T1 (el) 2018-12-12

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