EA201690501A1 - Новые композиции для лечения неврологических расстройств - Google Patents

Новые композиции для лечения неврологических расстройств

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Publication number
EA201690501A1
EA201690501A1 EA201690501A EA201690501A EA201690501A1 EA 201690501 A1 EA201690501 A1 EA 201690501A1 EA 201690501 A EA201690501 A EA 201690501A EA 201690501 A EA201690501 A EA 201690501A EA 201690501 A1 EA201690501 A1 EA 201690501A1
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EA
Eurasian Patent Office
Prior art keywords
disease
treatment
neurological disorders
new compositions
alzheimer
Prior art date
Application number
EA201690501A
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English (en)
Other versions
EA034075B1 (ru
Inventor
Даниель Коэн
Илья Чумаков
Сергей Набирочкин
Микаэль Гуэдж
Эмманюэль Вьяль
Original Assignee
Фарнексt
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Publication date
Application filed by Фарнексt filed Critical Фарнексt
Publication of EA201690501A1 publication Critical patent/EA201690501A1/ru
Publication of EA034075B1 publication Critical patent/EA034075B1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к композиции и способам для лечения неврологических расстройств, связанных с эксайтотоксичностью глутамата и токсичностью амилоида β. Более конкретно, настоящее изобретение относится к новым комбинированных терапиям рассеянного склероза, болезни Альцгеймера, расстройств, связанных с болезнями Альцгеймера, бокового амиотрофического склероза, болезни Паркинсона, болезни Хантингтона, невропатической боли, алкогольной невропатии, алкоголизма или алкогольной абстиненции или поражения спинного мозга.
EA201690501A 2013-08-30 2014-09-01 Применение комбинации, содержащей торасемид и баклофен, для регенерации нервов или нейронов и способ, ее использующий EA034075B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/014,650 US9867837B2 (en) 2011-03-01 2013-08-30 Compositions for treating neurological disorders
PCT/EP2014/068494 WO2015028659A1 (en) 2013-08-30 2014-09-01 Composition comprising torasemide and baclofen for treating neurological disorders

Publications (2)

Publication Number Publication Date
EA201690501A1 true EA201690501A1 (ru) 2016-08-31
EA034075B1 EA034075B1 (ru) 2019-12-25

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EA201690501A EA034075B1 (ru) 2013-08-30 2014-09-01 Применение комбинации, содержащей торасемид и баклофен, для регенерации нервов или нейронов и способ, ее использующий

Country Status (17)

Country Link
US (3) US9867837B2 (ru)
EP (1) EP3038614B1 (ru)
JP (1) JP6395838B2 (ru)
KR (1) KR20160067103A (ru)
CN (1) CN105744932B (ru)
AU (1) AU2014314055B2 (ru)
BR (1) BR112016004505A2 (ru)
CA (1) CA2922066A1 (ru)
EA (1) EA034075B1 (ru)
ES (1) ES2733954T3 (ru)
HK (1) HK1224182A1 (ru)
IL (1) IL244170A0 (ru)
MX (1) MX367023B (ru)
SG (1) SG11201601312WA (ru)
UA (1) UA119445C2 (ru)
WO (1) WO2015028659A1 (ru)
ZA (1) ZA201601634B (ru)

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CA2922066A1 (en) 2015-03-05
US9867837B2 (en) 2018-01-16
KR20160067103A (ko) 2016-06-13
WO2015028659A1 (en) 2015-03-05
CN105744932A (zh) 2016-07-06
EP3038614A1 (en) 2016-07-06
UA119445C2 (uk) 2019-06-25
HK1224182A1 (zh) 2017-08-18
US20180125867A1 (en) 2018-05-10
ZA201601634B (en) 2017-08-30
US20180338988A1 (en) 2018-11-29
AU2014314055A1 (en) 2016-03-10
EA034075B1 (ru) 2019-12-25
EP3038614B1 (en) 2019-04-03
ES2733954T3 (es) 2019-12-03
JP6395838B2 (ja) 2018-09-26
SG11201601312WA (en) 2016-03-30
US20140038927A1 (en) 2014-02-06
MX2016002644A (es) 2016-10-04
IL244170A0 (en) 2016-04-21
US10434109B2 (en) 2019-10-08
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AU2014314055B2 (en) 2019-11-21
MX367023B (es) 2019-08-01

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