CY1118848T1 - Ενωσεις 1,3-οξαζολιδινης ή 1,3-οξαζινανης ως ανταγωνιστες υποδοχεα ορεξινης - Google Patents

Ενωσεις 1,3-οξαζολιδινης ή 1,3-οξαζινανης ως ανταγωνιστες υποδοχεα ορεξινης

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Publication number
CY1118848T1
CY1118848T1 CY20171100300T CY171100300T CY1118848T1 CY 1118848 T1 CY1118848 T1 CY 1118848T1 CY 20171100300 T CY20171100300 T CY 20171100300T CY 171100300 T CY171100300 T CY 171100300T CY 1118848 T1 CY1118848 T1 CY 1118848T1
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CY
Cyprus
Prior art keywords
components
disorders
oxazolinin
oxazinine
orexin
Prior art date
Application number
CY20171100300T
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English (en)
Inventor
Aya Futamura
Yuko Araki
Masahiko Abe
Hiroshi Ohta
Ryo Suzuki
Dai Nozawa
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Taisho Pharmaceutical Co., Ltd.
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Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Publication of CY1118848T1 publication Critical patent/CY1118848T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355Non-condensed oxazines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
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    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P37/02Immunomodulators
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Παράγωγο ετεροαρωματικής μεθυλοκυκλικής αμίνης που αντιπροσωπεύεται από τον τύπο (ΙΑ) ή ένα φαρμακευτικώς αποδεκτό άλας αυτού είναι χρήσιμο για θεραπεία ή πρόληψη ασθενειών όπως διαταραχές ύπνου, κατάθλιψη, άγχος, πανικός, σχιζοφρένεια, εξάρτηση από φαρμακευτικές/ναρκωτικές ουσίες, νόσος Alzheimer, νόσος Parkinson, νόσος Huntington, διατροφικές διαταραχές, κεφαλαλγία, ημικρανία, πόνος, γαστρεντερικές παθήσεις, επιληψία, φλεγμονή, ανοσολογικές παθήσεις, ενδοκρινικές ασθένειες ή υπέρταση, με βάση την ανταγωνιστική του δράση έναντι υποδοχέων ορεξίνης (ΟΧ).
CY20171100300T 2012-06-15 2017-03-08 Ενωσεις 1,3-οξαζολιδινης ή 1,3-οξαζινανης ως ανταγωνιστες υποδοχεα ορεξινης CY1118848T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012135277 2012-06-15
PCT/JP2013/066322 WO2013187467A1 (ja) 2012-06-15 2013-06-13 ヘテロ芳香環メチル環状アミン誘導体

Publications (1)

Publication Number Publication Date
CY1118848T1 true CY1118848T1 (el) 2018-01-10

Family

ID=49758285

Family Applications (1)

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CY20171100300T CY1118848T1 (el) 2012-06-15 2017-03-08 Ενωσεις 1,3-οξαζολιδινης ή 1,3-οξαζινανης ως ανταγωνιστες υποδοχεα ορεξινης

Country Status (31)

Country Link
US (1) US9266870B2 (el)
EP (1) EP2862860B1 (el)
JP (1) JP5896319B2 (el)
KR (1) KR102098977B1 (el)
CN (1) CN104350053B (el)
AU (1) AU2013275210B2 (el)
BR (1) BR112014031360B1 (el)
CA (1) CA2876253C (el)
CY (1) CY1118848T1 (el)
DK (1) DK2862860T3 (el)
ES (1) ES2613663T3 (el)
HK (1) HK1202540A1 (el)
HR (1) HRP20161797T1 (el)
HU (1) HUE031538T2 (el)
IL (1) IL236140A (el)
IN (1) IN2014DN10490A (el)
LT (1) LT2862860T (el)
ME (1) ME02606B (el)
MX (1) MX355660B (el)
MY (1) MY171464A (el)
NZ (1) NZ702647A (el)
PH (1) PH12014502750A1 (el)
PL (1) PL2862860T3 (el)
PT (1) PT2862860T (el)
RS (1) RS55675B1 (el)
RU (1) RU2639869C2 (el)
SG (1) SG11201408327XA (el)
SI (1) SI2862860T1 (el)
TW (1) TWI583683B (el)
WO (1) WO2013187467A1 (el)
ZA (1) ZA201409168B (el)

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DK2491038T3 (da) 2009-10-23 2016-07-18 Janssen Pharmaceutica Nv Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer
JP5907310B2 (ja) * 2013-12-13 2016-04-26 大正製薬株式会社 オキサジナン化合物の結晶形及びその製造方法
JP2017024990A (ja) * 2013-12-13 2017-02-02 大正製薬株式会社 オキサゾリジン及びオキサジナン誘導体
CN104370755B (zh) * 2014-08-18 2017-04-12 江西隆莱生物制药有限公司 一种光学活性的3‑氨基丁醇和3‑氨基丁酸的制备方法
JP2018188364A (ja) * 2015-10-02 2018-11-29 大正製薬株式会社 複素芳香環誘導体
CA3016706A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
CN108129426B (zh) * 2016-12-01 2021-06-29 中国科学院大连化学物理研究所 一种2,5-二氰基呋喃催化加氢合成2,5-二甲胺基呋喃的方法
JOP20190156B1 (ar) * 2016-12-23 2023-09-17 Bayer Pharma AG أميدات عطرية لحمض الكربوكسيليك بصفتها مضادات لمستقبلة البراديكينين b1
JP7178002B2 (ja) * 2017-07-13 2022-11-25 大正製薬株式会社 (2s)-2-[(1h-ピラゾール-1-イル)メチル]-1,3-オキサジナン誘導体の製造方法
CN110967321A (zh) * 2018-09-29 2020-04-07 泰州医药城国科化物生物医药科技有限公司 一种用于均一体系细胞荧光检测钙流方法
JP2023526528A (ja) 2020-05-22 2023-06-21 ノイウェイ ファルマ ゲーエムベーハー 白質ジストロフィーの処置のためのvlp
CN113336655A (zh) * 2020-12-30 2021-09-03 江西迪赛诺制药有限公司 一种(r)-3-氨基丁醇的制备方法

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GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
US7169744B2 (en) * 2002-06-06 2007-01-30 Procter & Gamble Company Organic catalyst with enhanced solubility
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CA2739917A1 (en) 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. 2,5-disubstituted morpholine orexin receptor antagonists
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US20140081025A1 (en) 2011-05-10 2014-03-20 Taisho Pharmaceutical Co., Ltd. Heteroaromatic ring derivative

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Publication number Publication date
RS55675B1 (sr) 2017-06-30
HK1202540A1 (en) 2015-10-02
EP2862860B1 (en) 2016-12-21
US20150183768A1 (en) 2015-07-02
SI2862860T1 (sl) 2017-01-31
US9266870B2 (en) 2016-02-23
ZA201409168B (en) 2016-08-31
IL236140A (en) 2016-12-29
CA2876253C (en) 2020-07-07
HUE031538T2 (en) 2017-07-28
MY171464A (en) 2019-10-15
WO2013187467A1 (ja) 2013-12-19
PL2862860T3 (pl) 2017-06-30
CN104350053B (zh) 2017-03-08
SG11201408327XA (en) 2015-02-27
MX355660B (es) 2018-04-25
JP5896319B2 (ja) 2016-03-30
LT2862860T (lt) 2017-03-10
KR20150023391A (ko) 2015-03-05
DK2862860T3 (en) 2017-01-30
BR112014031360B1 (pt) 2022-04-12
BR112014031360A2 (pt) 2017-06-27
AU2013275210B2 (en) 2017-08-24
MX2014015077A (es) 2015-03-09
PT2862860T (pt) 2017-03-13
HRP20161797T1 (hr) 2017-02-24
KR102098977B1 (ko) 2020-04-08
AU2013275210A1 (en) 2015-01-22
TW201410674A (zh) 2014-03-16
ME02606B (me) 2017-06-20
RU2639869C2 (ru) 2017-12-25
JPWO2013187467A1 (ja) 2016-02-08
EP2862860A1 (en) 2015-04-22
RU2015101102A (ru) 2016-08-10
IN2014DN10490A (el) 2015-08-21
EP2862860A4 (en) 2015-11-04
NZ702647A (en) 2016-11-25
ES2613663T3 (es) 2017-05-25
CA2876253A1 (en) 2013-12-19
PH12014502750B1 (en) 2015-02-09
PH12014502750A1 (en) 2015-02-09
IL236140A0 (en) 2015-02-01
CN104350053A (zh) 2015-02-11
TWI583683B (zh) 2017-05-21

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