CY1116518T1 - Παραγωγο 1,2,4-τριαζολονης - Google Patents

Παραγωγο 1,2,4-τριαζολονης

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Publication number
CY1116518T1
CY1116518T1 CY20151100611T CY151100611T CY1116518T1 CY 1116518 T1 CY1116518 T1 CY 1116518T1 CY 20151100611 T CY20151100611 T CY 20151100611T CY 151100611 T CY151100611 T CY 151100611T CY 1116518 T1 CY1116518 T1 CY 1116518T1
Authority
CY
Cyprus
Prior art keywords
disorders
disease
cerebral
triazolone derivative
ilipsias
Prior art date
Application number
CY20151100611T
Other languages
English (en)
Inventor
Takeshi Kuwada
Mitsukane Yoshinaga
Tomoko Ishizaka
Daisuke Wakasugi
Shin-Ichi Shirokawa
Nobutaka Hattori
Youichi Shimazaki
Naoki Miyakoshi
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Publication of CY1116518T1 publication Critical patent/CY1116518T1/el

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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Abstract

Η παρούσα εφεύρεση παρέχει παράγωγο 1,2,4-τριαζολόνης που αντιπροσωπεύεται με τον γενικό τύπο (1Α), που δρα ως ανταγωνιστής υποδοχέα 1b αργινίνης αγγειοπιεσίνης• φαρμακολογικώς αποδεκτό άλας αυτού και φάρμακο που περιέχει αυτό ως δραστικό συστατικό, ιδιαιτέρως θεραπευτικό ή προφυλακτικό παράγοντα που δεικνύει ευνοϊκή in-vivo διάθεση στην περίπτωση διαταραχών ψυχικής διάθεσης, διαταραχών άγχους, σχιζοφρένειας, ασθένειας Alzheimer, ασθένειας Parkinson, ασθένειας Huntington, διατροφικών διαταραχών, υπέρτασης, γαστρεντερικών διαταραχών, εξάρτησης φαρμάκου, επιληψίας, εγκεφαλικής απόφραξης, εγκεφαλικής ισχαιμίας, εγκεφαλικού οιδήματος, τραύματος κεφαλής, φλεγμονής, ανοσολογικών διαταραχών, αλωπεκίας και άλλων ασθενειών.
CY20151100611T 2010-10-01 2015-07-13 Παραγωγο 1,2,4-τριαζολονης CY1116518T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010224233 2010-10-01
JP2011054500 2011-03-11
EP20110829344 EP2623499B1 (en) 2010-10-01 2011-09-30 1,2,4-triazolone derivative

Publications (1)

Publication Number Publication Date
CY1116518T1 true CY1116518T1 (el) 2017-03-15

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EP (1) EP2623499B1 (el)
JP (1) JP5787237B2 (el)
KR (1) KR101820185B1 (el)
CN (1) CN103119028B (el)
AU (1) AU2011308403B2 (el)
BR (1) BR112013007389B1 (el)
CA (1) CA2811192C (el)
CY (1) CY1116518T1 (el)
DK (1) DK2623499T3 (el)
ES (1) ES2536084T3 (el)
HK (1) HK1182109A1 (el)
HR (1) HRP20150462T1 (el)
HU (1) HUE025729T2 (el)
IL (1) IL225091A (el)
ME (1) ME02169B (el)
MX (1) MX2013003633A (el)
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JP5929812B2 (ja) * 2012-03-30 2016-06-08 大正製薬株式会社 １，２，４−トリアゾロン誘導体を含有する医薬
TWI568722B (zh) * 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
US9730447B2 (en) 2013-04-15 2017-08-15 E I Du Pont De Nemours And Company Fungicidal amides
JP6387669B2 (ja) * 2013-04-26 2018-09-12 大正製薬株式会社 アゾール誘導体を含有する医薬
US10800746B2 (en) * 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof

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