ME02169B - Derivat 1,2,4-triazolona - Google Patents

Derivat 1,2,4-triazolona

Info

Publication number
ME02169B
ME02169B MEP-2015-99A MEP9915A ME02169B ME 02169 B ME02169 B ME 02169B ME P9915 A MEP9915 A ME P9915A ME 02169 B ME02169 B ME 02169B
Authority
ME
Montenegro
Prior art keywords
cerebral
disease
compound
diseases
triazolone
Prior art date
Application number
MEP-2015-99A
Other languages
English (en)
Inventor
Takeshi Kuwada
Mitsukane Yoshinaga
Tomoko Ishizaka
Daisuke Wakasugi
Shin-Ichi Shirokawa
Nobutaka Hattori
Youichi Shimazaki
Naoki Miyakoshi
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of ME02169B publication Critical patent/ME02169B/me

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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

Predmetni pronalazak se odnosi najedinjenje koje ima 1,2,4-triazolonski skelet, a koje pokazuje antagonističkodejstvo na arginin-vazopresinski receptor (AVP)V1b, kao i na farmaceutskipreparat koji sadrži navedeno jedinjenje kao aktivni sastojak, konkretnije, naterapeutsko ili preventivno sredstvo za bolesti kao što su poremećajiraspoloženja, anksiozni poremećaj, šizofrenija, Alchajmerova bolest,Parkinsonova bolest, Hantingtonova horeja, poremećaji u ishrani, hipertenzija,gastrointestinalne bolesti, zavisnost od lekova, epilepsija, cerebralniinfarkt, cerebralna ishemija, cerebralni edem, povrede glave, zapaljenje,bolesti koje se dovode u vezu sa imunim sistemom i alopecija. 
MEP-2015-99A 2010-10-01 2011-09-30 Derivat 1,2,4-triazolona ME02169B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010224233 2010-10-01
JP2011054500 2011-03-11
EP20110829344 EP2623499B1 (en) 2010-10-01 2011-09-30 1,2,4-triazolone derivative
PCT/JP2011/072556 WO2012043791A1 (ja) 2010-10-01 2011-09-30 １，２，４-トリアゾロン誘導体

Publications (1)

Publication Number Publication Date
ME02169B true ME02169B (me) 2015-10-20

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US (1) US9193695B2 (me)
EP (1) EP2623499B1 (me)
JP (1) JP5787237B2 (me)
KR (1) KR101820185B1 (me)
CN (1) CN103119028B (me)
AU (1) AU2011308403B2 (me)
BR (1) BR112013007389B1 (me)
CA (1) CA2811192C (me)
CY (1) CY1116518T1 (me)
DK (1) DK2623499T3 (me)
ES (1) ES2536084T3 (me)
HK (1) HK1182109A1 (me)
HR (1) HRP20150462T1 (me)
HU (1) HUE025729T2 (me)
IL (1) IL225091A (me)
ME (1) ME02169B (me)
MX (1) MX2013003633A (me)
MY (1) MY165626A (me)
NZ (1) NZ608729A (me)
PL (1) PL2623499T3 (me)
PT (1) PT2623499E (me)
RS (1) RS54112B1 (me)
RU (1) RU2566754C2 (me)
SG (1) SG189156A1 (me)
SI (1) SI2623499T1 (me)
SM (1) SMT201500166B (me)
TW (1) TWI518075B (me)
WO (1) WO2012043791A1 (me)
ZA (1) ZA201302651B (me)

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TWI568722B (zh) * 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
AU2014254261B2 (en) 2013-04-15 2017-11-09 Fmc Corporation Fungicidal amides
JP6387669B2 (ja) * 2013-04-26 2018-09-12 大正製薬株式会社 アゾール誘導体を含有する医薬
CA3022755A1 (en) * 2016-05-03 2017-11-09 Carsten Schmeck Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof

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