PE20151788A1 - Inhibidores de bromodominios tetraciclicos - Google Patents

Inhibidores de bromodominios tetraciclicos

Info

Publication number
PE20151788A1
PE20151788A1 PE2015001915A PE2015001915A PE20151788A1 PE 20151788 A1 PE20151788 A1 PE 20151788A1 PE 2015001915 A PE2015001915 A PE 2015001915A PE 2015001915 A PE2015001915 A PE 2015001915A PE 20151788 A1 PE20151788 A1 PE 20151788A1
Authority
PE
Peru
Prior art keywords
tetracyclic
bromodomines
inhibitors
formula
compounds
Prior art date
Application number
PE2015001915A
Other languages
English (en)
Inventor
Steven D Fidanze
Dachun Liu
Robert A Mantei
Keith F Mcdaniel
John PRATT
George S Sheppard
Le Wang
Andrew Bogdan
James H Holms
Justin D Dietrich
Jasmina Marjanovic
Lisa A Hasvold
Yujia Dai
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20151788A1 publication Critical patent/PE20151788A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invencion provee compuestos tetraciclicos de formula (I), donde R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, y A4 tienen cualquiera de los valores definidos en la memoria descriptiva y sales farmaceuticamente aceptables de los mismos, que son utiles como agentes en el tratamiento de enfermedades y estados clinicos, incluyendo enfermedades inflamatorias, cancer y SIDA. Tambien se proveen composiciones farmaceuticas que comprenden uno o mas compuestos de formula (I)
PE2015001915A 2013-03-12 2014-03-12 Inhibidores de bromodominios tetraciclicos PE20151788A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777797P 2013-03-12 2013-03-12
US201461928779P 2014-01-17 2014-01-17

Publications (1)

Publication Number Publication Date
PE20151788A1 true PE20151788A1 (es) 2015-12-20

Family

ID=51535867

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015001915A PE20151788A1 (es) 2013-03-12 2014-03-12 Inhibidores de bromodominios tetraciclicos

Country Status (22)

Country Link
US (5) US10035800B2 (es)
EP (2) EP2970330B1 (es)
JP (2) JP6419735B2 (es)
KR (1) KR102224992B1 (es)
CN (2) CN108440528A (es)
AR (1) AR095266A1 (es)
AU (2) AU2014231563A1 (es)
BR (1) BR112015022391B1 (es)
CA (1) CA2903910C (es)
CR (1) CR20150474A (es)
DO (1) DOP2015000216A (es)
HK (1) HK1217102A1 (es)
IL (1) IL241010B (es)
MX (1) MX363913B (es)
PE (1) PE20151788A1 (es)
PH (1) PH12015502004A1 (es)
RU (1) RU2015143192A (es)
SG (1) SG11201507402WA (es)
TW (1) TWI635087B (es)
UY (1) UY35395A (es)
WO (1) WO2014139324A1 (es)
ZA (1) ZA201506477B (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2872213A1 (en) 2012-06-13 2013-12-19 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
UA116547C2 (uk) 2012-09-25 2018-04-10 Ф. Хоффманн-Ля Рош Аг Біциклічні похідні
US10035800B2 (en) * 2013-03-12 2018-07-31 Abbvie Inc. Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
TWI719464B (zh) 2013-03-15 2021-02-21 美商英塞特控股公司 作為bet蛋白抑制劑之三環雜環
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
MX2016001037A (es) 2013-07-25 2016-11-10 Dana Farber Cancer Inst Inc Inhibidores de factores de transcripción y usos.
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
CN105764905B (zh) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 新的八氢-环丁二烯并[1，2-c；3，4-c’]二吡咯-2基
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
WO2015117053A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
CA2935612A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
DK3674302T3 (da) 2014-04-23 2023-04-03 Incyte Holdings Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-oner og pyrazolo[3,4-c]pyridin-7(6h)-oner som inhibitorer af bet-proteiner
EP3177147A4 (en) 2014-08-08 2018-01-24 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
MA40940A (fr) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
MA40943A (fr) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
CN107108613B (zh) 2014-11-10 2020-02-25 基因泰克公司 布罗莫结构域抑制剂及其用途
JP6709792B2 (ja) 2015-01-29 2020-06-17 ジェネンテック， インコーポレイテッド 治療用化合物およびその使用
GB201504694D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Covalent conjugates
PT3277683T (pt) 2015-03-30 2022-06-28 Jubilant Biosys Ltd Derivados tricíclicos fundidos de 1-(ciclo)alquil piridina-2-ona úteis para o tratamento do cancro
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CR20180058A (es) 2015-09-04 2018-02-26 Hoffmann La Roche Nuevos derivados de fenoximetilo
RU2734959C2 (ru) 2015-09-09 2020-10-26 Джубилант Байосис Лимитед Трициклические конденсированные производные пиридин-2-она и их применение в качестве ингибиторов brd4
SG10202007099TA (en) 2015-09-11 2020-08-28 Dana Farber Cancer Inst Inc Acetamide thienotriazoldiazepines and uses thereof
AU2016319116B2 (en) 2015-09-11 2020-10-01 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
JP6846414B2 (ja) 2015-09-24 2021-03-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
CA2991615A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
EP3353178B1 (en) 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
CN107614505B (zh) 2015-09-24 2021-05-07 豪夫迈·罗氏有限公司 作为双重atx/ca抑制剂的新型二环化合物
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
KR20180081809A (ko) 2015-11-25 2018-07-17 다나-파버 캔서 인스티튜트 인크. 2가 브로모도메인 억제제 및 그의 용도
TWI764237B (zh) 2016-04-15 2022-05-11 美商艾伯維有限公司 溴域抑制劑
KR102643344B1 (ko) 2016-06-20 2024-03-07 인사이트 코포레이션 Bet 저해제의 결정질 고체 형태
EP3539960A4 (en) 2016-11-10 2020-03-18 Luoxin Pharmaceutical (Shanghai) Co., Ltd. NITROGEN MACROCYCLIC COMPOUND, ITS PREPARATION METHOD, ITS PHARMACEUTICAL COMPOSITION AND ITS APPLICATION
TW201825490A (zh) * 2017-01-11 2018-07-16 大陸商江蘇豪森藥業集團有限公司 吡咯並［２，３－ｃ］吡啶類衍生物、其製備方法及其在醫藥上的應用
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
US20210130346A1 (en) * 2017-04-14 2021-05-06 Abbvie Inc. Bromodomain Inhibitors
CN110305123B (zh) * 2018-03-27 2021-12-10 海创药业股份有限公司 一种含有金刚烷的化合物及其在治疗癌症中的用途
CN110865130B (zh) * 2018-08-27 2023-08-22 北京海晶生物医药科技有限公司 一种盐酸奥洛他定及其有关物质的检测方法
CA3115110A1 (en) 2018-10-24 2020-04-30 F. Hoffmann-La Roche Ag Conjugated chemical inducers of degradation and methods of use
WO2020092638A1 (en) 2018-10-30 2020-05-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
CN109394768B (zh) * 2018-12-10 2019-08-23 牡丹江医学院 一种治疗湿疹的药物及其制备方法
CN111377934B (zh) * 2018-12-29 2023-01-24 中国科学院上海药物研究所 一类杂环化合物，其制备及用途
CN111704610B (zh) * 2019-03-17 2022-03-22 上海凌达生物医药有限公司 一类吡咯酰胺并吡啶酮类化合物、制备方法和用途
KR20220028072A (ko) 2019-07-02 2022-03-08 누베이션 바이오 인크. Bet 억제제로서의 헤테로시클릭 화합물
WO2021121276A1 (zh) * 2019-12-17 2021-06-24 江苏恒瑞医药股份有限公司 稠合四环类衍生物、其制备方法及其在医药上的应用
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
AU2022254741A1 (en) * 2021-04-09 2023-11-16 Celgene Corporation Treatment of cancer with kdm4 inhibitors
GB2621505A (en) * 2021-06-29 2024-02-14 Tay Therapeutics Ltd Pyrrolopyridone derivatives useful in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI447120B (zh) 2005-05-30 2014-08-01 Mitsubishi Tanabe Pharma Corp 噻吩并三唑并苯二氮呯化合物、其醫藥上之用途
KR20090082453A (ko) * 2006-11-01 2009-07-30 버텍스 파마슈티칼스 인코포레이티드 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물
KR20120097508A (ko) * 2009-11-05 2012-09-04 글락소스미스클라인 엘엘씨 벤조디아제핀 브로모도메인 억제제
GB0919426D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
JP5844358B2 (ja) * 2010-06-22 2016-01-13 グラクソスミスクライン エルエルシー ベンゾトリアゾロジアゼピン化合物を含むブロモドメイン阻害剤
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US10035800B2 (en) * 2013-03-12 2018-07-31 Abbvie Inc. Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors

Also Published As

Publication number Publication date
EP2970330A1 (en) 2016-01-20
TWI635087B (zh) 2018-09-11
EP2970330A4 (en) 2016-10-19
JP2016510772A (ja) 2016-04-11
DOP2015000216A (es) 2015-11-30
US20180298003A1 (en) 2018-10-18
KR102224992B1 (ko) 2021-03-10
US20210070756A1 (en) 2021-03-11
ZA201506477B (en) 2020-02-26
SG11201507402WA (en) 2015-10-29
KR20150126050A (ko) 2015-11-10
WO2014139324A1 (en) 2014-09-18
BR112015022391A2 (pt) 2017-07-18
JP6419735B2 (ja) 2018-11-07
IL241010A0 (en) 2015-11-30
CA2903910A1 (en) 2014-09-18
CA2903910C (en) 2023-08-15
US10035800B2 (en) 2018-07-31
AU2014231563A1 (en) 2015-09-17
TW201512200A (zh) 2015-04-01
AR095266A1 (es) 2015-09-30
BR112015022391B1 (pt) 2021-12-21
US20160039821A1 (en) 2016-02-11
CN108440528A (zh) 2018-08-24
MX363913B (es) 2019-04-08
EP2970330B1 (en) 2019-04-17
CR20150474A (es) 2015-12-14
IL241010B (en) 2019-01-31
CN105026403B (zh) 2018-05-18
US20200291027A1 (en) 2020-09-17
HK1217102A1 (zh) 2016-12-23
BR112015022391A8 (pt) 2019-11-26
EP3539962A1 (en) 2019-09-18
JP2019014748A (ja) 2019-01-31
CN105026403A (zh) 2015-11-04
US20190389861A1 (en) 2019-12-26
MX2015012006A (es) 2015-12-01
AU2018203833A1 (en) 2018-06-21
PH12015502004A1 (en) 2016-01-11
UY35395A (es) 2014-10-31
RU2015143192A (ru) 2017-04-17

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