MX356865B - Nuevas soluciones terapéuticas para tratar la enfermedad de parkinson. - Google Patents

Nuevas soluciones terapéuticas para tratar la enfermedad de parkinson.

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Publication number
MX356865B
MX356865B MX2014010214A MX2014010214A MX356865B MX 356865 B MX356865 B MX 356865B MX 2014010214 A MX2014010214 A MX 2014010214A MX 2014010214 A MX2014010214 A MX 2014010214A MX 356865 B MX356865 B MX 356865B
Authority
MX
Mexico
Prior art keywords
disease
relates
treating parkinson
parkinson
methods
Prior art date
Application number
MX2014010214A
Other languages
English (en)
Other versions
MX2014010214A (es
Inventor
Cohen Daniel
Chumakov Ilya
Nabirochkin Serguei
Hajj Rodolphe
Original Assignee
Pharnext
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/053565 external-priority patent/WO2012117073A2/en
Priority claimed from PCT/EP2012/053568 external-priority patent/WO2012117075A2/en
Application filed by Pharnext filed Critical Pharnext
Publication of MX2014010214A publication Critical patent/MX2014010214A/es
Publication of MX356865B publication Critical patent/MX356865B/es

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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

La presente invención se refiere a composiciones y métodos para el tratamiento de la enfermedad de Parkinson y los trastornos relacionados. Más específicamente, La presente invención se refiere a novedosos tratamientos combinados de la enfermedad de Parkinson y los trastornos relacionados que se dirigen a la red de agregación de la alfa-sinucleína. En particular, la invención se refiere a compuestos que, solos o en combinación(es), pueden proteger eficazmente las células neuronales de los agregados de alfa-sinucleína. La invención se refiere también a los métodos de producir un fármaco o una combinación de fármacos para tratar la enfermedad de Parkinson y a los métodos para tratar la enfermedad de Parkinson o un trastorno relacionado.
MX2014010214A 2012-03-01 2013-02-28 Nuevas soluciones terapéuticas para tratar la enfermedad de parkinson. MX356865B (es)

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PCT/EP2012/053565 WO2012117073A2 (en) 2011-03-01 2012-03-01 New compositions for treating neurological disorders
PCT/EP2012/053568 WO2012117075A2 (en) 2011-03-01 2012-03-01 Treatment of cerebral ischemia
PCT/EP2012/053570 WO2012117076A2 (en) 2011-03-01 2012-03-01 Baclofen and acamprosate based therapy of neurogical disorders
US201261696992P 2012-09-05 2012-09-05
EP12306063.4A EP2705842A1 (en) 2012-09-05 2012-09-05 Therapeutic approaches for treating parkinson's disease
PCT/EP2013/054026 WO2013127918A1 (en) 2012-03-01 2013-02-28 New therapeutic approaches for treating parkinson's disease

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