PE20090282A1 - Azetidinas como agentes antagonistas de ep2 - Google Patents
Azetidinas como agentes antagonistas de ep2Info
- Publication number
- PE20090282A1 PE20090282A1 PE2008000813A PE2008000813A PE20090282A1 PE 20090282 A1 PE20090282 A1 PE 20090282A1 PE 2008000813 A PE2008000813 A PE 2008000813A PE 2008000813 A PE2008000813 A PE 2008000813A PE 20090282 A1 PE20090282 A1 PE 20090282A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxyl
- methyl
- azetidin
- oxy
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE AZETIDINA DE FORMULA (I), DONDE R1 ES UN GRUPO TETRAHIDROPIRANILO O UN FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, F, PERFLUOROALQUILO C1-C6, ENTRE OTROS; X ES UN ENLACE DIRECTO O NH; Z ES -C(=O)-O-R2, -C(=O)-NH-SO2R3 O CN; R2 Y R3 SON H O ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON FLUOR; Ar ES UN GRUPO AROMATICO CONSTITUIDO POR 1 A 3 ANILLOS AROMATICOS SELECCIONADOS DE FENILO Y UN ANILLO HETEROAROMATICO DE 5 O 6 MIEMBROS QUE CONTIENE DE 1 A 3 HETEROATOMOS TALES COMO N, O Y S. SON COMPUESTOS PREFERIDOS: ACIDO 1-(4-FLUOROBENZOIL)-3-{[(66-METOXI-2-NAFTIL)OXI]METIL}AZETIDIN-3-CARBOXILICO, ACIDO 3-{[(2'-CLOROBIFENIL-4-IL)OXI]METIL}-1-(4-FLUOROBENZOIL)AZETIDIN-3-CARBOXILICO, ACIDO 1-BENZOIL-3-{[(5-FENILPIRAZIN-2-IL)OXI]METIL}AZETIDIN-3-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR 2 DE PROSTAGLANDINAS E2 (PGE2) O EP2 Y SON UTILES EN EL TRATAMIENTO DE ENDOMETRIOSIS, MIOMAS UTERINOS, ADENOMIOSIS, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91708107P | 2007-05-10 | 2007-05-10 | |
US1303007P | 2007-12-12 | 2007-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090282A1 true PE20090282A1 (es) | 2009-03-27 |
Family
ID=39739736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000813A PE20090282A1 (es) | 2007-05-10 | 2008-05-08 | Azetidinas como agentes antagonistas de ep2 |
Country Status (27)
Country | Link |
---|---|
US (1) | US20080280877A1 (es) |
EP (1) | EP2155666A1 (es) |
JP (1) | JP2010526801A (es) |
KR (1) | KR20100009582A (es) |
CN (1) | CN101679235A (es) |
AP (1) | AP2009005047A0 (es) |
AR (1) | AR066524A1 (es) |
AU (1) | AU2008249744A1 (es) |
BR (1) | BRPI0811444A2 (es) |
CA (1) | CA2686517A1 (es) |
CL (1) | CL2008001305A1 (es) |
CO (1) | CO6260066A2 (es) |
CR (1) | CR11101A (es) |
DO (1) | DOP2009000256A (es) |
EA (1) | EA200901381A1 (es) |
EC (1) | ECSP099727A (es) |
GT (1) | GT200900293A (es) |
IL (1) | IL201874A0 (es) |
MA (1) | MA31366B1 (es) |
MX (1) | MX2009011998A (es) |
PA (1) | PA8779601A1 (es) |
PE (1) | PE20090282A1 (es) |
SV (1) | SV2009003407A (es) |
TN (1) | TN2009000470A1 (es) |
TW (1) | TW200904409A (es) |
UY (1) | UY31070A1 (es) |
WO (1) | WO2008139287A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2222665A1 (en) * | 2007-11-15 | 2010-09-01 | Pfizer Limited | Azetidines as ep2 antagonists |
AP2011005728A0 (en) * | 2008-11-10 | 2011-06-30 | Pfizer Ltd | Pyrrolidines. |
KR20120028867A (ko) * | 2009-04-02 | 2012-03-23 | 알러간, 인코포레이티드 | 프로스타글란딘 e 수용체 길항제 |
DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
WO2013010679A1 (en) * | 2011-07-15 | 2013-01-24 | Novartis Ag | Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors |
TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
JP2017538769A (ja) | 2014-12-22 | 2017-12-28 | ファイザー・インク | プロスタグランジンep3受容体の拮抗薬 |
CN110041269A (zh) * | 2019-05-16 | 2019-07-23 | 海门瑞一医药科技有限公司 | 一种2-氯-5-羟基嘧啶的制备方法 |
EP4359399A1 (en) * | 2021-06-24 | 2024-05-01 | Reservoir Neuroscience, Inc. | Ep2 antagonist compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8300860D0 (en) * | 1983-01-13 | 1983-02-16 | Shell Int Research | Azetidine compounds |
GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
GB8509746D0 (en) * | 1985-04-16 | 1985-05-22 | Shell Int Research | Preparing azetidine derivatives |
TW200300757A (en) | 2001-11-16 | 2003-06-16 | Schering Corp | Azetidinyl diamines useful as ligands of the nociceptin receptor orl-1 |
CA3052368A1 (en) * | 2005-10-07 | 2007-04-19 | Exelixis, Inc. | Azetidines as mek inhibitors |
US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
-
2008
- 2008-04-28 KR KR1020097025684A patent/KR20100009582A/ko not_active Application Discontinuation
- 2008-04-28 JP JP2010507013A patent/JP2010526801A/ja not_active Withdrawn
- 2008-04-28 CN CN200880019555A patent/CN101679235A/zh active Pending
- 2008-04-28 MX MX2009011998A patent/MX2009011998A/es not_active Application Discontinuation
- 2008-04-28 AU AU2008249744A patent/AU2008249744A1/en not_active Abandoned
- 2008-04-28 EP EP08737574A patent/EP2155666A1/en not_active Withdrawn
- 2008-04-28 BR BRPI0811444-7A2A patent/BRPI0811444A2/pt not_active IP Right Cessation
- 2008-04-28 WO PCT/IB2008/001070 patent/WO2008139287A1/en active Application Filing
- 2008-04-28 EA EA200901381A patent/EA200901381A1/ru unknown
- 2008-04-28 AP AP2009005047A patent/AP2009005047A0/en unknown
- 2008-04-28 CA CA002686517A patent/CA2686517A1/en not_active Abandoned
- 2008-05-05 US US12/115,070 patent/US20080280877A1/en not_active Abandoned
- 2008-05-06 CL CL200801305A patent/CL2008001305A1/es unknown
- 2008-05-08 PA PA20088779601A patent/PA8779601A1/es unknown
- 2008-05-08 PE PE2008000813A patent/PE20090282A1/es not_active Application Discontinuation
- 2008-05-08 UY UY31070A patent/UY31070A1/es not_active Application Discontinuation
- 2008-05-09 AR ARP080101988A patent/AR066524A1/es unknown
- 2008-05-09 TW TW097117225A patent/TW200904409A/zh unknown
-
2009
- 2009-11-01 IL IL201874A patent/IL201874A0/en unknown
- 2009-11-05 DO DO2009000256A patent/DOP2009000256A/es unknown
- 2009-11-06 TN TNP2009000470A patent/TN2009000470A1/fr unknown
- 2009-11-06 SV SV2009003407A patent/SV2009003407A/es not_active Application Discontinuation
- 2009-11-09 CR CR11101A patent/CR11101A/es not_active Application Discontinuation
- 2009-11-09 CO CO09126880A patent/CO6260066A2/es not_active Application Discontinuation
- 2009-11-10 EC EC2009009727A patent/ECSP099727A/es unknown
- 2009-11-10 MA MA32331A patent/MA31366B1/fr unknown
- 2009-11-10 GT GT200900293A patent/GT200900293A/es unknown
Also Published As
Publication number | Publication date |
---|---|
DOP2009000256A (es) | 2009-11-30 |
TN2009000470A1 (fr) | 2011-03-31 |
ECSP099727A (es) | 2009-12-28 |
CN101679235A (zh) | 2010-03-24 |
CO6260066A2 (es) | 2011-03-22 |
BRPI0811444A2 (pt) | 2014-10-29 |
MX2009011998A (es) | 2009-11-19 |
IL201874A0 (en) | 2010-06-16 |
CA2686517A1 (en) | 2008-11-20 |
SV2009003407A (es) | 2010-01-12 |
UY31070A1 (es) | 2009-01-05 |
PA8779601A1 (es) | 2009-01-23 |
CL2008001305A1 (es) | 2008-07-18 |
EP2155666A1 (en) | 2010-02-24 |
JP2010526801A (ja) | 2010-08-05 |
MA31366B1 (fr) | 2010-05-03 |
US20080280877A1 (en) | 2008-11-13 |
AU2008249744A1 (en) | 2008-11-20 |
CR11101A (es) | 2009-12-04 |
EA200901381A1 (ru) | 2010-06-30 |
WO2008139287A1 (en) | 2008-11-20 |
AR066524A1 (es) | 2009-08-26 |
AP2009005047A0 (en) | 2009-12-31 |
TW200904409A (en) | 2009-02-01 |
KR20100009582A (ko) | 2010-01-27 |
GT200900293A (es) | 2010-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |