CO6260066A2 - Derivados de azetidina y su uso como antagonistas de prostaglandina e2 - Google Patents
Derivados de azetidina y su uso como antagonistas de prostaglandina e2Info
- Publication number
- CO6260066A2 CO6260066A2 CO09126880A CO09126880A CO6260066A2 CO 6260066 A2 CO6260066 A2 CO 6260066A2 CO 09126880 A CO09126880 A CO 09126880A CO 09126880 A CO09126880 A CO 09126880A CO 6260066 A2 CO6260066 A2 CO 6260066A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- optionally substituted
- independently selected
- aromatic rings
- perfluoroalkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de fórmula (I):en la que R1 es un grupo fenilo (opcionalmente sustituido con uno o dos sustituyentes independientemente seleccionados de F, CI, Br, CN, alquilo C1-4, alquiltio C1-4 y alcoxi C1-4, perfluoroalquilo C1-6 y perfluoroalcoxi C1-6, o un grupo tetrahidropiranilo; X representa un enlace directo o NH; Z se selecciona de R2 y R3, R4 y R5 son H o alquilo C1-6 (opcionalmente sustituido con de 1 a 3 átomos de flúor); Ar es un grupo aromático que está constituido por 1, 2 ó 3 anillos aromáticos, anillos aromáticos que se seleccionan independientemente de fenilo y un anillo heteroaromático de 5 ó 6 miembros que contiene 1, 2 ó 3 heteroátomos independientemente seleccionados de N, O y S; y cuyos anillos aromáticos, si hay 2 o más, pueden condensarse o ligarse mediante uno o más enlaces covalentes, y cuyos anillos aromáticos están opcionalmente sustituidos con 1, 2 ó 3 sustituyentes independientemente seleccionados de F, CI, CN, OH, alquilo C1-6, alquiltio C1-6, perfluoroalquilo C1-6, perfluoroalquiltio C1-6, perfluoroalcoxi C1-6, alcoxi C1-6, SO2R4, NR5R6, NHSO2R7, SO2NR8R9, C0NR10R11 y NHCOR12; R4, R5, R6, R7, R8, R9, R10, R11 y R12 son H o alquilo C1-6 (opcionalmente sustituido con de 1 a 3 átomos de flúor); o una sal, solvato o profármaco farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91708107P | 2007-05-10 | 2007-05-10 | |
| US1303007P | 2007-12-12 | 2007-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6260066A2 true CO6260066A2 (es) | 2011-03-22 |
Family
ID=39739736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09126880A CO6260066A2 (es) | 2007-05-10 | 2009-11-09 | Derivados de azetidina y su uso como antagonistas de prostaglandina e2 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20080280877A1 (es) |
| EP (1) | EP2155666A1 (es) |
| JP (1) | JP2010526801A (es) |
| KR (1) | KR20100009582A (es) |
| CN (1) | CN101679235A (es) |
| AP (1) | AP2009005047A0 (es) |
| AR (1) | AR066524A1 (es) |
| AU (1) | AU2008249744A1 (es) |
| BR (1) | BRPI0811444A2 (es) |
| CA (1) | CA2686517A1 (es) |
| CL (1) | CL2008001305A1 (es) |
| CO (1) | CO6260066A2 (es) |
| CR (1) | CR11101A (es) |
| DO (1) | DOP2009000256A (es) |
| EA (1) | EA200901381A1 (es) |
| EC (1) | ECSP099727A (es) |
| GT (1) | GT200900293A (es) |
| IL (1) | IL201874A0 (es) |
| MA (1) | MA31366B1 (es) |
| MX (1) | MX2009011998A (es) |
| PA (1) | PA8779601A1 (es) |
| PE (1) | PE20090282A1 (es) |
| SV (1) | SV2009003407A (es) |
| TN (1) | TN2009000470A1 (es) |
| TW (1) | TW200904409A (es) |
| UY (1) | UY31070A1 (es) |
| WO (1) | WO2008139287A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2222665A1 (en) * | 2007-11-15 | 2010-09-01 | Pfizer Limited | Azetidines as ep2 antagonists |
| CN102209710A (zh) | 2008-11-10 | 2011-10-05 | 辉瑞股份有限公司 | 吡咯烷类化合物 |
| US20100256385A1 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| JP6263469B2 (ja) | 2011-07-15 | 2018-01-17 | ノバルティス アーゲー | アザ二環式ジ−アリールエーテルの塩およびその製造方法またはその前駆体の製造方法 |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| EP3237401B1 (en) | 2014-12-22 | 2019-03-06 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
| CN110041269A (zh) * | 2019-05-16 | 2019-07-23 | 海门瑞一医药科技有限公司 | 一种2-氯-5-羟基嘧啶的制备方法 |
| WO2022272062A1 (en) * | 2021-06-24 | 2022-12-29 | Reservoir Neuroscience, Inc. | Ep2 antagonist compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8300860D0 (en) * | 1983-01-13 | 1983-02-16 | Shell Int Research | Azetidine compounds |
| GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
| GB8509746D0 (en) * | 1985-04-16 | 1985-05-22 | Shell Int Research | Preparing azetidine derivatives |
| AR037364A1 (es) | 2001-11-16 | 2004-11-03 | Schering Corp | Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1 |
| BRPI0617165B1 (pt) * | 2005-10-07 | 2023-10-03 | Exelixis Inc | Compostos inibidores mek, composições farmacêuticas que os contem e métodos de uso dos mesmos |
| US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
-
2008
- 2008-04-28 WO PCT/IB2008/001070 patent/WO2008139287A1/en active Application Filing
- 2008-04-28 JP JP2010507013A patent/JP2010526801A/ja not_active Withdrawn
- 2008-04-28 CA CA002686517A patent/CA2686517A1/en not_active Abandoned
- 2008-04-28 KR KR1020097025684A patent/KR20100009582A/ko not_active Application Discontinuation
- 2008-04-28 MX MX2009011998A patent/MX2009011998A/es not_active Application Discontinuation
- 2008-04-28 CN CN200880019555A patent/CN101679235A/zh active Pending
- 2008-04-28 AP AP2009005047A patent/AP2009005047A0/en unknown
- 2008-04-28 AU AU2008249744A patent/AU2008249744A1/en not_active Abandoned
- 2008-04-28 EA EA200901381A patent/EA200901381A1/ru unknown
- 2008-04-28 BR BRPI0811444-7A2A patent/BRPI0811444A2/pt not_active IP Right Cessation
- 2008-04-28 EP EP08737574A patent/EP2155666A1/en not_active Withdrawn
- 2008-05-05 US US12/115,070 patent/US20080280877A1/en not_active Abandoned
- 2008-05-06 CL CL200801305A patent/CL2008001305A1/es unknown
- 2008-05-08 PA PA20088779601A patent/PA8779601A1/es unknown
- 2008-05-08 UY UY31070A patent/UY31070A1/es not_active Application Discontinuation
- 2008-05-08 PE PE2008000813A patent/PE20090282A1/es not_active Application Discontinuation
- 2008-05-09 TW TW097117225A patent/TW200904409A/zh unknown
- 2008-05-09 AR ARP080101988A patent/AR066524A1/es unknown
-
2009
- 2009-11-01 IL IL201874A patent/IL201874A0/en unknown
- 2009-11-05 DO DO2009000256A patent/DOP2009000256A/es unknown
- 2009-11-06 SV SV2009003407A patent/SV2009003407A/es not_active Application Discontinuation
- 2009-11-06 TN TNP2009000470A patent/TN2009000470A1/fr unknown
- 2009-11-09 CO CO09126880A patent/CO6260066A2/es not_active Application Discontinuation
- 2009-11-09 CR CR11101A patent/CR11101A/es not_active Application Discontinuation
- 2009-11-10 GT GT200900293A patent/GT200900293A/es unknown
- 2009-11-10 MA MA32331A patent/MA31366B1/fr unknown
- 2009-11-10 EC EC2009009727A patent/ECSP099727A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0811444A2 (pt) | 2014-10-29 |
| MX2009011998A (es) | 2009-11-19 |
| EA200901381A1 (ru) | 2010-06-30 |
| IL201874A0 (en) | 2010-06-16 |
| SV2009003407A (es) | 2010-01-12 |
| EP2155666A1 (en) | 2010-02-24 |
| UY31070A1 (es) | 2009-01-05 |
| AR066524A1 (es) | 2009-08-26 |
| CR11101A (es) | 2009-12-04 |
| PA8779601A1 (es) | 2009-01-23 |
| AU2008249744A1 (en) | 2008-11-20 |
| ECSP099727A (es) | 2009-12-28 |
| GT200900293A (es) | 2010-05-17 |
| WO2008139287A1 (en) | 2008-11-20 |
| DOP2009000256A (es) | 2009-11-30 |
| MA31366B1 (fr) | 2010-05-03 |
| CL2008001305A1 (es) | 2008-07-18 |
| AP2009005047A0 (en) | 2009-12-31 |
| CA2686517A1 (en) | 2008-11-20 |
| TW200904409A (en) | 2009-02-01 |
| US20080280877A1 (en) | 2008-11-13 |
| CN101679235A (zh) | 2010-03-24 |
| KR20100009582A (ko) | 2010-01-27 |
| TN2009000470A1 (fr) | 2011-03-31 |
| PE20090282A1 (es) | 2009-03-27 |
| JP2010526801A (ja) | 2010-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |