PE20091828A1 - Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino como inhibidores de edg-2 - Google Patents

Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino como inhibidores de edg-2

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Publication number
PE20091828A1
PE20091828A1 PE2009000599A PE2009000599A PE20091828A1 PE 20091828 A1 PE20091828 A1 PE 20091828A1 PE 2009000599 A PE2009000599 A PE 2009000599A PE 2009000599 A PE2009000599 A PE 2009000599A PE 20091828 A1 PE20091828 A1 PE 20091828A1
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PE
Peru
Prior art keywords
edg
inhibitors
acid
indano
benzoylamine
Prior art date
Application number
PE2009000599A
Other languages
English (en)
Inventor
Werngard Czechtizky
Dieter Kadereit
Josef Pernerstorfer
Matthias Schaefer
Hartmut Strobel
Charlie Chen
Marcel Patek
Alena Safarova
Aleksandra Weichsel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39870123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091828(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20091828A1 publication Critical patent/PE20091828A1/es

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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

REFERIDA A UN DERIVADO DE ACIDO CICLOPENTANOCARBOXILICO DE FORMULA (I), DONDE A ES UN ANILLO CICLOALCANO DE 3 A 7 MIEMBROS, UN ANILLO BENCENO O UN ANILLO HETERICICLICO AROMATICO MONOCICLICO DE 5 O 6 MIEMBROS, ENTRE OTROS; Y ES S, O, C(R12)=C(R13), ENTRE OTROS; Z ES N O C(R16); R12, R13 Y R16 SON H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; R3 Y R5 SON H, ALQUILO C1-C4, FENILO, ENTRE OTROS; R21 Y R22 SON H, OH, NH2, ENTRE OTROS; R50 ES -O-R51 O R52-N(R53)-; R4, R6, R20, R51, R52 Y R53 SON H O ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: ACIDO 2-[4-METILSULFANIL-3-(2-m-TOLIL-ETOXI)-BENZOILAMINO]-INDANO-2-CARBOXILICO, ACIDO 2-[4-ACETIL-3-(2-m-TOLIL-ETOXI)-BENZOILAMINO]-INDANO-2-CARBOXILICO, ACIDO 2-[4-ETIL-3-(2-m-TOLIL-ETOXI)-BENZOILAMINO]-INDANO-2-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DEL GEN DE DIFERENCIACION ENDOTELIAL 2 (Edg-2, EDG-2) QUE ES ACTIVADO POR ACIDO LISOFOSFATIDICO (LPA1) Y SON UTILES EN EL TRATAMIENTO DE INFARTO DE MIOCARDIO, ATEROSCLEROSIS, ENTRE OTROS
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