MA32368B1 - Derives d'acide cyclopentanecarboxylique condensé acylamino-substitues et leur utilisation en tant qu'agents pharmaceutiques - Google Patents

Derives d'acide cyclopentanecarboxylique condensé acylamino-substitues et leur utilisation en tant qu'agents pharmaceutiques

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Publication number
MA32368B1
MA32368B1 MA33383A MA33383A MA32368B1 MA 32368 B1 MA32368 B1 MA 32368B1 MA 33383 A MA33383 A MA 33383A MA 33383 A MA33383 A MA 33383A MA 32368 B1 MA32368 B1 MA 32368B1
Authority
MA
Morocco
Prior art keywords
intensive
drugs
substituted acyl
acyl amino
compounds
Prior art date
Application number
MA33383A
Other languages
Arabic (ar)
English (en)
Inventor
Matthias Schaefer
Josef Pernerstorfer
Dieter Kadereit
Hartmut Strobel
Werngard Czechtizky
L Charlie Chen
Alena Safarova
Aleksandra Weichsel
Marcel Patek
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39870123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32368(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA32368B1 publication Critical patent/MA32368B1/fr

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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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Abstract

La présente invention concerne des composés qui sont représentés par la formule (i) dans laquelle a, y, z, r3 à r6, r20 à r22 et r50 ont les significations données dans les revendications et qui constituent des composés pharmaceutiques actifs intéressants. En l'occurrence, ce sont des inhibiteurs du récepteur 2 du gène de différentiation endothéliale (edg-2, edg2) qui est activé par l'acide lysophosphatidique (lpa) et que l'on appelle également lpa1. Ces composés conviennent au traitement d'affections telles que l'athérosclérose, l'infarctus du myocarde et l'insuffisance cardiaque. L'invention concerne en outre des procédés destinés à l'élaboration des composés représentés par la formule (i), leur utilisation, et des compositions pharmaceutique les comprenant.
MA33383A 2008-05-05 2010-12-01 Derives d'acide cyclopentanecarboxylique condensé acylamino-substitues et leur utilisation en tant qu'agents pharmaceutiques MA32368B1 (fr)

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US11733608P 2008-11-24 2008-11-24
PCT/EP2009/002917 WO2009135590A1 (fr) 2008-05-05 2009-04-22 Dérivés fusionnés d'acide cyclopentane-carboxylique à substitution acylamino, et leur utilisation comme produits pharmaceutiques

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