MX347157B - Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. - Google Patents

Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas.

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Publication number
MX347157B
MX347157B MX2014010974A MX2014010974A MX347157B MX 347157 B MX347157 B MX 347157B MX 2014010974 A MX2014010974 A MX 2014010974A MX 2014010974 A MX2014010974 A MX 2014010974A MX 347157 B MX347157 B MX 347157B
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MX
Mexico
Prior art keywords
sup
heteroaroylamino
pharmaceuticals
substituted
diseases
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Application number
MX2014010974A
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English (en)
Inventor
Ruf Sven
Sadowski Thorsten
Schreuder Herman
Buning Christian
Wirth Klaus
Original Assignee
Sanofi Sa
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Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX347157B publication Critical patent/MX347157B/es

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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Abstract

La presente invención se refiere a compuestos de fórmula I, (ver Fórmula) en la que A, D, E, L, G, R10, R30, R40, R50 y R60 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Son inhibidores de la proteasa catepsina A, y son útiles, por ejemplo, para el tratamiento de enfermedades tales como aterosclerosis, insuficiencia cardiaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
MX2014010974A 2011-01-26 2012-01-26 Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. MX347157B (es)

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EP2667870A1 (en) 2013-12-04
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CL2013002129A1 (es) 2013-12-20
US20140194445A1 (en) 2014-07-10
BR112013016508A2 (pt) 2016-09-27
KR20140007399A (ko) 2014-01-17
RU2013139349A (ru) 2015-03-10
ZA201304463B (en) 2014-02-26
SI2667870T1 (sl) 2016-12-30
US8669370B2 (en) 2014-03-11
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PH12013501300A1 (en) 2013-08-28
MX340370B (es) 2016-07-07
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IL227025A (en) 2017-05-29
US20120252809A1 (en) 2012-10-04
JP2014505063A (ja) 2014-02-27
PT2667870T (pt) 2016-11-16
US9120783B2 (en) 2015-09-01
EP2667870B1 (en) 2016-08-24
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JP5957467B2 (ja) 2016-07-27
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CA2822120C (en) 2019-02-26
US20140135328A1 (en) 2014-05-15
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US9029559B2 (en) 2015-05-12
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