CO6761373A2 - Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas - Google Patents

Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas

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Publication number
CO6761373A2
CO6761373A2 CO13200355A CO13200355A CO6761373A2 CO 6761373 A2 CO6761373 A2 CO 6761373A2 CO 13200355 A CO13200355 A CO 13200355A CO 13200355 A CO13200355 A CO 13200355A CO 6761373 A2 CO6761373 A2 CO 6761373A2
Authority
CO
Colombia
Prior art keywords
heteroaroylamino
substituted
propionic acid
acid derivatives
pharmaceutical substances
Prior art date
Application number
CO13200355A
Other languages
English (en)
Inventor
Sven Ruf
Thorsten Sadowski
Klaus Wirth
Herman Schreuder
Christian Buning
Original Assignee
Sanofi Sa
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44041622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6761373(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO6761373A2 publication Critical patent/CO6761373A2/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Abstract

La presente invención se refiere a compuestos de fórmula I,en la que A, D, E, L, G, R, R, R, Ry Rtienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Son inhibidores de la proteasa catepsina A, y son útiles, por ejemplo, para el tratamiento de enfermedades tales como aterosclerosis, insuficiencia cardiaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
CO13200355A 2011-01-26 2013-08-23 Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas CO6761373A2 (es)

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