CY1117397T1 - Παραγωγα 3-ετεροαρουλαμινο-προπιονικου οξεος και χρηση τους ως φαρμακευτικα - Google Patents
Παραγωγα 3-ετεροαρουλαμινο-προπιονικου οξεος και χρηση τους ως φαρμακευτικαInfo
- Publication number
- CY1117397T1 CY1117397T1 CY20161100093T CY161100093T CY1117397T1 CY 1117397 T1 CY1117397 T1 CY 1117397T1 CY 20161100093 T CY20161100093 T CY 20161100093T CY 161100093 T CY161100093 T CY 161100093T CY 1117397 T1 CY1117397 T1 CY 1117397T1
- Authority
- CY
- Cyprus
- Prior art keywords
- teteroululamine
- pharmaceuticals
- propionic acid
- acid products
- compounds
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
Η παρούσα εφεύρεση σχετίζεται με ενώσεις του τύπου I, όπου Ht, G, R10, R30, R40, R50 και R60 έχουν τις έννοιες που υποδεικνύονται στις αξιώσεις, οι οποίες είναι πολύτιμες φαρμακευτικές δραστικές ενώσεις. Είναι αναστολείς της πρωτεάσης καθεψίνης Α, και είναι χρήσιμες για τη θεραπεία νόσων όπως αθηροσκλήρωση, καρδιακή ανεπάρκεια, νεφρικές νόσοι, ηπατικές νόσοι ή φλεγμονώδεις νόσοι, για παράδειγμα. Η εφεύρεση επιπλέον σχετίζεται με διαδικασίες για την παρασκευή των ενώσεων του τύπου I, την χρήση τους και φαρμακευτικές συνθέσεις που τις περιέχουν.
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EP11305971 | 2011-07-26 | ||
EP12738473.3A EP2736888B1 (en) | 2011-07-26 | 2012-07-25 | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
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CY1117397T1 true CY1117397T1 (el) | 2017-04-26 |
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US (2) | US9353068B2 (el) |
EP (2) | EP3037417B1 (el) |
JP (2) | JP6021910B2 (el) |
KR (1) | KR20140049019A (el) |
CN (2) | CN103827097B (el) |
AU (2) | AU2012288842A1 (el) |
BR (1) | BR112014001518A2 (el) |
CA (1) | CA2841905A1 (el) |
CY (1) | CY1117397T1 (el) |
DK (1) | DK2736888T3 (el) |
ES (1) | ES2560381T3 (el) |
HK (2) | HK1192559A1 (el) |
HR (1) | HRP20160047T1 (el) |
HU (1) | HUE028418T2 (el) |
IL (2) | IL230126A (el) |
MX (1) | MX337173B (el) |
MY (1) | MY169319A (el) |
PL (1) | PL2736888T3 (el) |
PT (1) | PT2736888E (el) |
RU (1) | RU2014107000A (el) |
SI (1) | SI2736888T1 (el) |
WO (1) | WO2013014204A2 (el) |
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AU2012288843B2 (en) * | 2011-07-26 | 2016-08-04 | Sanofi | Substituted 3 - (thiazole - 4 - carbonyl) - or 3 - (thiazole - 2 - carbonyl) aminopropionic acid derivatives and their use as pharmaceuticals |
CN104603118B (zh) | 2012-05-31 | 2017-10-03 | 菲尼克斯药品股份公司 | 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物 |
JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
WO2014053533A1 (en) | 2012-10-05 | 2014-04-10 | Sanofi | Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation |
MX2015013799A (es) | 2013-03-28 | 2016-02-16 | Sanofi Sa | Derivados de acido-biaril-propionico y su uso como productos farmaceuticos. |
AU2014243069B2 (en) | 2013-03-28 | 2017-12-21 | Sanofi | Biaryl-propionic acid derivatives and their use as pharmaceuticals |
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JP2019501899A (ja) | 2015-12-09 | 2019-01-24 | リサーチ トライアングル インスティテュート | 改良アペリンレセプター(apj)アゴニストおよびその使用 |
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2012
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- 2012-07-25 DK DK12738473.3T patent/DK2736888T3/da active
- 2012-07-25 PT PT127384733T patent/PT2736888E/pt unknown
- 2012-07-25 EP EP15190731.8A patent/EP3037417B1/en not_active Not-in-force
- 2012-07-25 AU AU2012288842A patent/AU2012288842A1/en not_active Abandoned
- 2012-07-25 WO PCT/EP2012/064628 patent/WO2013014204A2/en active Application Filing
- 2012-07-25 RU RU2014107000/04A patent/RU2014107000A/ru not_active Application Discontinuation
- 2012-07-25 KR KR1020147004756A patent/KR20140049019A/ko not_active Application Discontinuation
- 2012-07-25 ES ES12738473.3T patent/ES2560381T3/es active Active
- 2012-07-25 SI SI201230439T patent/SI2736888T1/sl unknown
- 2012-07-25 PL PL12738473T patent/PL2736888T3/pl unknown
- 2012-07-25 MY MYPI2013004643A patent/MY169319A/en unknown
- 2012-07-25 BR BR112014001518A patent/BR112014001518A2/pt not_active IP Right Cessation
- 2012-07-25 MX MX2014000598A patent/MX337173B/es active IP Right Grant
- 2012-07-25 EP EP12738473.3A patent/EP2736888B1/en not_active Not-in-force
- 2012-07-25 CN CN201511021647.3A patent/CN105646362B/zh not_active Expired - Fee Related
- 2012-07-25 JP JP2014522086A patent/JP6021910B2/ja not_active Expired - Fee Related
- 2012-07-25 CA CA2841905A patent/CA2841905A1/en not_active Abandoned
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2013
- 2013-12-23 IL IL230126A patent/IL230126A/en not_active IP Right Cessation
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2014
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2016
- 2016-01-15 HR HRP20160047TT patent/HRP20160047T1/hr unknown
- 2016-02-03 CY CY20161100093T patent/CY1117397T1/el unknown
- 2016-04-27 US US15/140,350 patent/US9751858B2/en not_active Expired - Fee Related
- 2016-09-30 JP JP2016192793A patent/JP6360534B2/ja not_active Expired - Fee Related
- 2016-12-06 HK HK16113874A patent/HK1225714A1/zh unknown
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2017
- 2017-01-31 IL IL250370A patent/IL250370A0/en unknown
- 2017-06-02 AU AU2017203739A patent/AU2017203739A1/en not_active Abandoned
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