MX2015013800A - Derivados de acido-biaril-propionico y su uso como productos farmaceuticos. - Google Patents
Derivados de acido-biaril-propionico y su uso como productos farmaceuticos.Info
- Publication number
- MX2015013800A MX2015013800A MX2015013800A MX2015013800A MX2015013800A MX 2015013800 A MX2015013800 A MX 2015013800A MX 2015013800 A MX2015013800 A MX 2015013800A MX 2015013800 A MX2015013800 A MX 2015013800A MX 2015013800 A MX2015013800 A MX 2015013800A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- biaryl
- pharmaceuticals
- propionic acid
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención se refiere a compuestos de la fórmula I, en donde X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 y G4 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Ellos son inhibidores de la proteasa catepsina A, y son útiles para el tratamiento de enfermedades tales como ateroesclerosis, insuficiencia cardíaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias, por ejemplo. La invención se refiere además a procedimientos para la preparación de los compuestos de la fórmula I, a su uso y a las composiciones farmacéuticas que los contienen. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13305401 | 2013-03-28 | ||
PCT/EP2014/056014 WO2014154726A1 (en) | 2013-03-28 | 2014-03-26 | Biaryl-propionic acid derivatives and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015013800A true MX2015013800A (es) | 2016-06-02 |
Family
ID=48050627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015013800A MX2015013800A (es) | 2013-03-28 | 2014-03-26 | Derivados de acido-biaril-propionico y su uso como productos farmaceuticos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US9150526B2 (es) |
EP (1) | EP2978754B1 (es) |
JP (1) | JP6359634B2 (es) |
KR (1) | KR20150136507A (es) |
CN (1) | CN105051038B (es) |
AR (1) | AR095764A1 (es) |
AU (1) | AU2014243069B2 (es) |
CA (1) | CA2907903A1 (es) |
IL (1) | IL240422B (es) |
MX (1) | MX2015013800A (es) |
SG (1) | SG11201506190QA (es) |
TW (1) | TW201514158A (es) |
UY (1) | UY35515A (es) |
WO (1) | WO2014154726A1 (es) |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5051518A (en) * | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
US20040072802A1 (en) | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
WO2004056815A1 (en) | 2002-12-23 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS |
JP2005145839A (ja) | 2003-11-12 | 2005-06-09 | Japan Science & Technology Agency | 新規なカテプシンa阻害剤 |
JP5123668B2 (ja) | 2005-01-10 | 2013-01-23 | エグゼリクシス, インコーポレイテッド | 医薬品としての複素環カルボキサミド化合物 |
WO2009080226A2 (en) | 2007-12-26 | 2009-07-02 | Sanofis-Aventis | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
JP5560202B2 (ja) | 2007-12-26 | 2014-07-23 | サノフイ | P2y12拮抗薬としてのピラゾール−カルボキサミド誘導体 |
AR079967A1 (es) * | 2010-01-26 | 2012-02-29 | Sanofi Aventis | Derivados de acido 3-heteroaroilamino-propionico sustituidos con oxigeno y su uso como productos farmaceuticos |
TWI523844B (zh) | 2011-01-26 | 2016-03-01 | 賽諾菲公司 | 經胺基取代之3-雜芳醯基胺基-丙酸衍生物及其作為藥物之用途 |
UY33874A (es) | 2011-01-26 | 2012-08-31 | Sanofi Aventis | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas |
MY162786A (en) | 2011-07-26 | 2017-07-14 | Sanofi Sa | Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals |
ES2560381T3 (es) | 2011-07-26 | 2016-02-18 | Sanofi | Derivados de ácido 3-heteroaroilamino-propiónico y su uso como productos farmacéuticos |
US20130123276A1 (en) | 2011-11-14 | 2013-05-16 | Sven Ruf | Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
WO2013072327A1 (en) | 2011-11-14 | 2013-05-23 | Sanofi | Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
-
2014
- 2014-03-26 CN CN201480018444.6A patent/CN105051038B/zh not_active Expired - Fee Related
- 2014-03-26 MX MX2015013800A patent/MX2015013800A/es unknown
- 2014-03-26 AU AU2014243069A patent/AU2014243069B2/en not_active Ceased
- 2014-03-26 WO PCT/EP2014/056014 patent/WO2014154726A1/en active Application Filing
- 2014-03-26 SG SG11201506190QA patent/SG11201506190QA/en unknown
- 2014-03-26 EP EP14712667.6A patent/EP2978754B1/en not_active Not-in-force
- 2014-03-26 JP JP2016504648A patent/JP6359634B2/ja not_active Expired - Fee Related
- 2014-03-26 CA CA2907903A patent/CA2907903A1/en not_active Abandoned
- 2014-03-26 AR ARP140101374A patent/AR095764A1/es unknown
- 2014-03-26 TW TW103111163A patent/TW201514158A/zh unknown
- 2014-03-26 KR KR1020157030497A patent/KR20150136507A/ko not_active Application Discontinuation
- 2014-03-27 US US14/227,679 patent/US9150526B2/en not_active Expired - Fee Related
- 2014-03-28 UY UY35515A patent/UY35515A/es not_active Application Discontinuation
-
2015
- 2015-08-06 IL IL240422A patent/IL240422B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP6359634B2 (ja) | 2018-07-18 |
CN105051038B (zh) | 2018-08-03 |
SG11201506190QA (en) | 2015-09-29 |
KR20150136507A (ko) | 2015-12-07 |
US9150526B2 (en) | 2015-10-06 |
JP2016515558A (ja) | 2016-05-30 |
TW201514158A (zh) | 2015-04-16 |
AU2014243069B2 (en) | 2017-12-21 |
IL240422B (en) | 2018-12-31 |
CN105051038A (zh) | 2015-11-11 |
US20140296296A1 (en) | 2014-10-02 |
EP2978754A1 (en) | 2016-02-03 |
CA2907903A1 (en) | 2014-10-02 |
WO2014154726A1 (en) | 2014-10-02 |
IL240422A0 (en) | 2015-09-24 |
EP2978754B1 (en) | 2017-05-10 |
AU2014243069A1 (en) | 2015-09-24 |
AR095764A1 (es) | 2015-11-11 |
UY35515A (es) | 2014-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY169319A (en) | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | |
MY156569A (en) | Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | |
PH12018502747A1 (en) | Boronic acid derivatives and therapeutic uses thereof | |
PH12017501921A1 (en) | Novel compounds | |
MX347157B (es) | Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. | |
MY165087A (en) | Neprilysin inhibitors | |
MY162786A (en) | Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals | |
MX2013006802A (es) | Inhibidores de neprilisina. | |
MY170935A (en) | Neprilysin inhibitors | |
MY163394A (en) | Substituted aminobutyric derivates as neprilysin inhibitors | |
MX2013007987A (es) | Derivados de acido 3-heteroaroilamino-propionico amino-sustituidos y su uso como productos farmaceuticos. | |
MX2017014035A (es) | Formas solidas novedosas. | |
PH12016501462A1 (en) | Neprilysin inhibitors | |
EA201291217A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 1-(β-D-ГЛЮКОПИРАНОЗИЛ)-2-ТИЕНИЛМЕТИЛБЕНЗОЛА КАК ИНГИБИТОРЫ НЗПГ | |
MX2015015393A (es) | Derivado de acido cicloalquilo, metodo de preparacion del mismo, y aplicacion farmaceutica del mismo. | |
PH12017501397A1 (en) | (2s, 4r)-5-(5`-chloro-2`-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor | |
MX2015001834A (es) | Nuevos compuestos antibacterianos. | |
WO2011047055A8 (en) | Novel mek inhibitors, useful in the treatment of diseases | |
MX2015013799A (es) | Derivados de acido-biaril-propionico y su uso como productos farmaceuticos. | |
UA116877C2 (uk) | Сполука з антибактеріальною і/абопротивірусною активністю | |
MX2015013800A (es) | Derivados de acido-biaril-propionico y su uso como productos farmaceuticos. |