AR095764A1 - Derivados de ácido biaril-propiónico y su uso como productos farmacéuticos - Google Patents
Derivados de ácido biaril-propiónico y su uso como productos farmacéuticosInfo
- Publication number
- AR095764A1 AR095764A1 ARP140101374A ARP140101374A AR095764A1 AR 095764 A1 AR095764 A1 AR 095764A1 AR P140101374 A ARP140101374 A AR P140101374A AR P140101374 A ARP140101374 A AR P140101374A AR 095764 A1 AR095764 A1 AR 095764A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ocf3
- cycloalkyl
- ch2oh
- diseases
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ellos son inhibidores de la proteasa catepsina A, y son útiles para el tratamiento de enfermedades tales como ateroesclerosis, insuficiencia cardíaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias, por ejemplo, se refiere además a procedimientos para la preparación de los compuestos de la fórmula (1), a su uso y a las composiciones farmacéuticas que los contienen. Reivindicación 1: Un compuesto de la fórmula (1), en cualquiera de sus formas estereoisómeras o una mezcla de formas estereoisómeras en cualquier proporción, o una de sus sales fisiológicamente aceptables, o un solvato fisiológicamente aceptable de cualquiera de ellas, en donde los significados son: X es S ó O; D es N o -C(R3)=; R es H, alquilo C₁₋₆, cicloalquilo C₃₋₈; R¹ es H, alquilo C₁₋₆, cicloalquilo C₃₋₈, alquilen C₁₋₆-cicloalquilo C₃₋₈; en donde alquilo está opcionalmente sustituido con uno o más átomos de F; R³ es H, metilo o etilo; R² es hidrógeno o alquilo C₁₋₆; E¹ es N o -C(R⁴)=; E² es N o -C(R⁵)=; E³ es N o -C(R⁶)=; E⁴ es N o -C(R⁷)=; en donde ninguno o uno de E¹, E², E³ o E⁴ es N; R⁴ es H o O-alquilo C₁₋₆; R⁵ es H, F, Cl, CF₃, alquilo C₁₋₆, cicloalquilo C₁₋₆; R⁶ es H o -O-CH₂-fenilo; R⁷ es H; G¹ es N o -C(R⁸)=; G² es N o -C(R⁹)=; G³ es N o -C(R¹⁰)=; G⁴ es N o -C(R¹¹)=; en donde ninguno o uno de G¹, G², G³ o G⁴ es N; o G³ y G⁴ son -C(R¹⁰)= y -C(R¹¹)=, en donde R¹⁰ y R¹¹ forman un carbociclo o heterociclo saturado de 4 a 7 miembros con uno o dos átomos de oxígeno; que está opcionalmente monosustituido o disustituido con alquilo C₁₋₃; R⁸ es H, F, Cl, alquilo C₁₋₆, O-alquilo C₁₋₆, CF₃ o OCF₃; R⁹ es H, F, Cl, OH, O-alquilo C₁₋₆, CH₂OH, CO-NH₂, alquilo C₁₋₆, O-alquilo C₁₋₆, CF₃ o OCF₃; R¹⁰ es H, F, Cl, OH, alquilo C₁₋₆, CH₂OH, CO-O-alquilo C₁₋₆, SO₂-alquilo C₁₋₆, CN, O-alquilo C₁₋₆, CF₃, CH₂-CN, (C(CH₃)₂)-CN, alquil C₁₋₆-OH, -O-alquil C₁₋₆-OH, -O-CH₂-CO-alquilo C₁₋₆ o OCF₃; R¹¹ es H, F, Cl, OH, O-alquilo C₁₋₆, CH₂OH, CO-C₁₋₆-metilo, CO-N(R²⁰R²¹), CO-O-alquilo C₁₋₆, CN, alquilo C₁₋₆, O-alquilo C₁₋₆ o OCF₃; en donde R²⁰ y R²¹ son independientemente uno de otro, H o alquilo C₁₋₃ o forman junto con el nitrógeno al que están unidos un anillo saturado de 5 ó 6 miembros.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13305401 | 2013-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR095764A1 true AR095764A1 (es) | 2015-11-11 |
Family
ID=48050627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101374A AR095764A1 (es) | 2013-03-28 | 2014-03-26 | Derivados de ácido biaril-propiónico y su uso como productos farmacéuticos |
Country Status (14)
Country | Link |
---|---|
US (1) | US9150526B2 (es) |
EP (1) | EP2978754B1 (es) |
JP (1) | JP6359634B2 (es) |
KR (1) | KR20150136507A (es) |
CN (1) | CN105051038B (es) |
AR (1) | AR095764A1 (es) |
AU (1) | AU2014243069B2 (es) |
CA (1) | CA2907903A1 (es) |
IL (1) | IL240422B (es) |
MX (1) | MX2015013800A (es) |
SG (1) | SG11201506190QA (es) |
TW (1) | TW201514158A (es) |
UY (1) | UY35515A (es) |
WO (1) | WO2014154726A1 (es) |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5051518A (en) * | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
US20040072802A1 (en) | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
MXPA05006200A (es) | 2002-12-23 | 2005-08-19 | Aventis Pharma Gmbh | Derivados de pirazol como inhibidores del factor xa. |
JP2005145839A (ja) | 2003-11-12 | 2005-06-09 | Japan Science & Technology Agency | 新規なカテプシンa阻害剤 |
WO2006076202A1 (en) | 2005-01-10 | 2006-07-20 | Exelixis, Inc. | Heterocyclic carboxamide compounds as steroid nuclear receptors ligands |
WO2009080226A2 (en) | 2007-12-26 | 2009-07-02 | Sanofis-Aventis | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
EP2238127B1 (en) | 2007-12-26 | 2012-08-15 | Sanofi | Pyrazole-carboxamide derivatives as p2y12 antagonists |
TWI532725B (zh) * | 2010-01-26 | 2016-05-11 | 賽諾菲阿凡提斯公司 | 經氧取代之3-雜芳醯基胺基-丙酸衍生物及其作為藥物之用途 |
AR085013A1 (es) | 2011-01-26 | 2013-08-07 | Sanofi Aventis | Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas |
TWI523844B (zh) * | 2011-01-26 | 2016-03-01 | 賽諾菲公司 | 經胺基取代之3-雜芳醯基胺基-丙酸衍生物及其作為藥物之用途 |
CA2841905A1 (en) * | 2011-07-26 | 2013-01-31 | Sanofi | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
RU2617843C2 (ru) * | 2011-07-26 | 2017-04-28 | Санофи | Замещенные производные 3-тиазолоаминопропионовой кислоты и их применение в качестве фармацевтических препаратов |
US20130123276A1 (en) | 2011-11-14 | 2013-05-16 | Sven Ruf | Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
US20130123325A1 (en) | 2011-11-14 | 2013-05-16 | Sven Ruf | Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
-
2014
- 2014-03-26 CA CA2907903A patent/CA2907903A1/en not_active Abandoned
- 2014-03-26 EP EP14712667.6A patent/EP2978754B1/en not_active Not-in-force
- 2014-03-26 CN CN201480018444.6A patent/CN105051038B/zh not_active Expired - Fee Related
- 2014-03-26 WO PCT/EP2014/056014 patent/WO2014154726A1/en active Application Filing
- 2014-03-26 JP JP2016504648A patent/JP6359634B2/ja not_active Expired - Fee Related
- 2014-03-26 SG SG11201506190QA patent/SG11201506190QA/en unknown
- 2014-03-26 AR ARP140101374A patent/AR095764A1/es unknown
- 2014-03-26 KR KR1020157030497A patent/KR20150136507A/ko not_active Application Discontinuation
- 2014-03-26 MX MX2015013800A patent/MX2015013800A/es unknown
- 2014-03-26 AU AU2014243069A patent/AU2014243069B2/en not_active Ceased
- 2014-03-26 TW TW103111163A patent/TW201514158A/zh unknown
- 2014-03-27 US US14/227,679 patent/US9150526B2/en not_active Expired - Fee Related
- 2014-03-28 UY UY35515A patent/UY35515A/es not_active Application Discontinuation
-
2015
- 2015-08-06 IL IL240422A patent/IL240422B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2978754A1 (en) | 2016-02-03 |
KR20150136507A (ko) | 2015-12-07 |
AU2014243069A1 (en) | 2015-09-24 |
IL240422B (en) | 2018-12-31 |
AU2014243069B2 (en) | 2017-12-21 |
TW201514158A (zh) | 2015-04-16 |
US9150526B2 (en) | 2015-10-06 |
IL240422A0 (en) | 2015-09-24 |
MX2015013800A (es) | 2016-06-02 |
JP6359634B2 (ja) | 2018-07-18 |
JP2016515558A (ja) | 2016-05-30 |
CN105051038B (zh) | 2018-08-03 |
EP2978754B1 (en) | 2017-05-10 |
UY35515A (es) | 2014-10-31 |
CA2907903A1 (en) | 2014-10-02 |
WO2014154726A1 (en) | 2014-10-02 |
SG11201506190QA (en) | 2015-09-29 |
US20140296296A1 (en) | 2014-10-02 |
CN105051038A (zh) | 2015-11-11 |
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