AR102177A1 - Compuestos de heteroarilo como inhibidores de btk y usos de los mismos - Google Patents
Compuestos de heteroarilo como inhibidores de btk y usos de los mismosInfo
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- AR102177A1 AR102177A1 ARP150103209A ARP150103209A AR102177A1 AR 102177 A1 AR102177 A1 AR 102177A1 AR P150103209 A ARP150103209 A AR P150103209A AR P150103209 A ARP150103209 A AR P150103209A AR 102177 A1 AR102177 A1 AR 102177A1
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- ring
- sulfur
- nitrogen
- oxygen
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract
Compuestos de imidazo piridina, y composiciones farmacéuticamente aceptables de los mismos, útiles como inhibidores de BTK. Reivindicación 1: Un compuesto de fórmula (1), o un tautómero, o una sal farmacéuticamente aceptable del mismo, donde: el Anillo A es un arilo o heteroarilo de 5 a 6 miembros; R¹ es H, halo, (C(R⁵)(R⁵))ₘNR², N(R⁴)C(O)R, N(R⁴)C(O)NR₂, N(R⁴)CO₂R, N(R⁴)S(O)₂R, N(R⁴)S(O)R, N(R⁴)(R⁴), anillo heterocíclico opcionalmente sustituido de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, o anillo heteroarilo monocíclico opcionalmente sustituido de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; o R¹ está ausente; R² es H, (C(R⁵)(R⁵))ₘOR⁴, (C(R⁵)(R⁵))ₘN(R⁴)COR, (C(R⁵)(R⁵))ₘN(R⁴)C(O)C(O)NR₂, (C(R⁵)(R⁵))ₘN(R⁴)(R⁴), anillo heterocíclico opcionalmente sustituido de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, o anillo heteroarilo monocíclico opcionalmente sustituido de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; o R² está ausente; o R¹ y R² junto con los átomos a los que están conectados, forman un anillo condensado de 3 a 7 miembros que está opcionalmente sustituido; donde R¹ y R² no son ninguno H; y donde R¹ y R² no está ninguno ausente; cada R³ es independientemente halógeno, alifático C₁₋₆, arilo C₅₋₁₀, un anillo carbocíclico saturado o parcialmente insaturado de 3 a 8 miembros, un anillo heterocíclico de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, o un anillo heteroarilo monocíclico de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; cada uno de los cuales está opcionalmente sustituido; cada R⁴ es independientemente -R, -SO₂R, -SOR, -C(O)R, -CO₂R o -C(O)N(R)₂; cada R⁵ es independientemente -R, halógeno, -OR, -SR, -CN, -NO₂, -SO₂R, -SOR, -C(O)R, -CO₂R, -C(O)N(R)₂, -NRC(O)R, -NRC(O)N(R)₂, -NRSO₂R o -N(R)₂; cada R es independientemente hidrógeno, alifático C₁₋₆, arilo C₅₋₁₀, un anillo carbocíclico saturado o parcialmente insaturado de 3 a 8 miembros, un anillo heterocíclico de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, o un anillo heteroarilo monocíclico de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; cada uno de los cuales está opcionalmente sustituido; o dos grupos R en el mismo átomo se toman junto con el átomo al que están unidos para formar un arilo C₅₋₁₀, un anillo carbocíclico saturado o parcialmente insaturado de 3 a 8 miembros, un anillo heterocíclico de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, un anillo heteroarilo monocíclico de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; un anillo arilo condensado de 10 a 15 miembros; un anillo carbocíclico condensado saturado o parcialmente insaturado de 6 a 15 miembros; un anillo heteroarilo condensado de 10 a 15 miembros; o un anillo heterocíclico condensado saturado o parcialmente insaturado de 6 a 15 miembros; cada uno de los cuales está opcionalmente sustituido; el Anillo Z es arilo C₅₋₁₀, un anillo carbocíclico saturado o parcialmente insaturado de 3 a 8 miembros, un anillo heterocíclico de 3 a 7 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre, o un anillo heteroarilo monocíclico de 5 a 6 miembros que tiene 1 - 4 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno o azufre; cada uno de los cuales está opcionalmente sustituido; o el Anillo Z está ausente; cada Rᵃ es independientemente -R, halógeno, -OR, -SR, -CN, -NO₂, -SO₂R, -SOR, -C(O)R, -CO₂R, -C(O)N(R)₂, -NRC(O)R, -NRC(O)N(R)₂, -NRSO₂R o -N(R)₂; m es 1, 2 ó 3; n es 0, 1 ó 2; y p es 0, 1, 2 ó 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201462060249P | 2014-10-06 | 2014-10-06 |
Publications (1)
Publication Number | Publication Date |
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AR102177A1 true AR102177A1 (es) | 2017-02-08 |
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Application Number | Title | Priority Date | Filing Date |
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ARP150103209A AR102177A1 (es) | 2014-10-06 | 2015-10-06 | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos |
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US (2) | US10253023B2 (es) |
EP (1) | EP3204382B1 (es) |
JP (1) | JP6856526B2 (es) |
KR (1) | KR102523111B1 (es) |
CN (1) | CN107001362A (es) |
AR (1) | AR102177A1 (es) |
AU (1) | AU2015328285B2 (es) |
BR (1) | BR112017006305B1 (es) |
CA (1) | CA2960401C (es) |
CL (1) | CL2017000786A1 (es) |
ES (1) | ES2907622T3 (es) |
IL (1) | IL251441B (es) |
MX (1) | MX2017004200A (es) |
NZ (1) | NZ729603A (es) |
PH (1) | PH12017500408A1 (es) |
RU (1) | RU2742122C2 (es) |
SG (1) | SG11201701573QA (es) |
WO (1) | WO2016057500A1 (es) |
ZA (1) | ZA201701501B (es) |
Families Citing this family (58)
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SI3080103T1 (sl) * | 2013-12-11 | 2018-11-30 | Biogen Ma Inc. | Biarilne spojine, ki so uporabne za zdravljenje človeških bolezni na področju onkologije, nevrologije in imunologije |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
AU2016358100B2 (en) | 2015-11-19 | 2021-05-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
DK3394033T3 (da) | 2015-12-22 | 2021-01-04 | Incyte Corp | Heterocykliske forbindelser som immunmodulatorer |
MA44860A (fr) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
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AU2015328285A1 (en) | 2017-03-23 |
ES2907622T3 (es) | 2022-04-25 |
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PH12017500408A1 (en) | 2017-07-17 |
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