MX2023003183A - Compuestos heterociclicos de heteroarilo y usos de los mismos. - Google Patents

Compuestos heterociclicos de heteroarilo y usos de los mismos.

Info

Publication number
MX2023003183A
MX2023003183A MX2023003183A MX2023003183A MX2023003183A MX 2023003183 A MX2023003183 A MX 2023003183A MX 2023003183 A MX2023003183 A MX 2023003183A MX 2023003183 A MX2023003183 A MX 2023003183A MX 2023003183 A MX2023003183 A MX 2023003183A
Authority
MX
Mexico
Prior art keywords
heterocyclic compounds
heteroaryl heterocyclic
heteroaryl
compounds
same
Prior art date
Application number
MX2023003183A
Other languages
English (en)
Inventor
Guangxiu Dai
Kun Xiao
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of MX2023003183A publication Critical patent/MX2023003183A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

La presente invención se relaciona con compuestos heterocíclicos de heteroarilo de la fórmula (I), composiciones farmacéuticas que los comprenden, métodos para prepararlos y usos de estos, en donde las variables son como se define en la descripción. (ver Fórmula).
MX2023003183A 2020-09-21 2021-09-17 Compuestos heterociclicos de heteroarilo y usos de los mismos. MX2023003183A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN202010993583 2020-09-21
CN202110175357 2021-02-07
CN202111077860 2021-09-15
PCT/CN2021/119056 WO2022057894A1 (en) 2020-09-21 2021-09-17 Heteroaryl heterocyclic compounds and uses thereof

Publications (1)

Publication Number Publication Date
MX2023003183A true MX2023003183A (es) 2023-04-12

Family

ID=80775929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023003183A MX2023003183A (es) 2020-09-21 2021-09-17 Compuestos heterociclicos de heteroarilo y usos de los mismos.

Country Status (13)

Country Link
US (2) US11655254B2 (es)
EP (1) EP4214206A1 (es)
JP (1) JP2023542040A (es)
KR (1) KR20230104125A (es)
CN (1) CN116568687A (es)
AU (1) AU2021343591A1 (es)
CA (1) CA3195525A1 (es)
CL (1) CL2023000772A1 (es)
IL (1) IL301275A (es)
MX (1) MX2023003183A (es)
PE (1) PE20232044A1 (es)
TW (1) TW202220998A (es)
WO (1) WO2022057894A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL301275A (en) * 2020-09-21 2023-05-01 Hutchison Medipharma Ltd Heterocyclic heteroaryl compounds and their uses
WO2023143491A1 (zh) * 2022-01-28 2023-08-03 和记黄埔医药（上海）有限公司 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5318952B2 (ja) 2008-07-15 2013-10-16 エフ．ホフマン−ラ ロシュ アーゲー 新規なフェニル−イミダゾピリジン類及びピリダジン類
CA3034600C (en) 2010-05-07 2020-11-10 Genentech, Inc. Pyridone and aza-pyridone compounds and methods of use
US8669251B2 (en) 2011-11-03 2014-03-11 Genentech, Inc. 8-fluorophthalazin-1(2H)-one compounds
JP5808869B2 (ja) * 2011-11-03 2015-11-10 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 二環式ピペラジン化合物
JP5976828B2 (ja) 2011-11-03 2016-08-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｂｔｋ活性阻害剤としてのアルキル化ピペラジン化合物
UA111756C2 (uk) * 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
JP5832664B2 (ja) 2011-12-09 2015-12-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトン型チロシンキナーゼの阻害剤
KR101815360B1 (ko) * 2013-07-03 2018-01-04 에프. 호프만-라 로슈 아게 헤테로아릴 피리돈 및 아자-피리돈 아마이드 화합물
EP3077384B1 (en) 2013-12-05 2017-09-06 F. Hoffmann-La Roche AG Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
CN106922146B (zh) 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
CN107001362A (zh) * 2014-10-06 2017-08-01 默克专利有限公司 用作btk抑制剂的杂芳基化合物及其用途
CA3034239A1 (en) 2016-08-16 2018-02-22 Merck Patent Gmbh 2-oxo-imidazopyridines as reversible btk inhibitors and uses thereof
TWI766176B (zh) 2016-12-15 2022-06-01 瑞士商赫孚孟拉羅股份公司 製備btk抑制劑之方法
UY37559A (es) 2017-01-06 2018-05-31 Pharmacyclics Llc Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton
US11100492B2 (en) 2018-02-19 2021-08-24 Peter Garrett General purpose re-loadable card aggregation implementation
CN110256446B (zh) * 2018-08-01 2021-12-14 上海海雁医药科技有限公司 苯并杂环取代的环戊二烯并[4,5]吡咯并吡嗪-1-酮衍生物及其应用
EP4107154A4 (en) * 2020-02-20 2024-02-28 Hutchison Medipharma Ltd HETEROARYL HETEROCYCLIC COMPOUNDS AND THEIR USES
IL301275A (en) * 2020-09-21 2023-05-01 Hutchison Medipharma Ltd Heterocyclic heteroaryl compounds and their uses

Also Published As

Publication number Publication date
CA3195525A1 (en) 2022-03-24
CL2023000772A1 (es) 2023-09-01
US11655254B2 (en) 2023-05-23
US20230382916A1 (en) 2023-11-30
JP2023542040A (ja) 2023-10-04
WO2022057894A1 (en) 2022-03-24
CN116568687A (zh) 2023-08-08
AU2021343591A1 (en) 2023-05-04
EP4214206A1 (en) 2023-07-26
US20220332719A1 (en) 2022-10-20
IL301275A (en) 2023-05-01
KR20230104125A (ko) 2023-07-07
PE20232044A1 (es) 2023-12-27
TW202220998A (zh) 2022-06-01

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