MX340370B - Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. - Google Patents

Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas.

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Publication number
MX340370B
MX340370B MX2014010972A MX2014010972A MX340370B MX 340370 B MX340370 B MX 340370B MX 2014010972 A MX2014010972 A MX 2014010972A MX 2014010972 A MX2014010972 A MX 2014010972A MX 340370 B MX340370 B MX 340370B
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MX
Mexico
Prior art keywords
heteroaroylamino
pharmaceuticals
substituted
diseases
propionic acid
Prior art date
Application number
MX2014010972A
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English (en)
Inventor
Ruf Sven
Sadowski Thorsten
Buning Christian
Wirth Klaus
Herman Schreuder
Original Assignee
Sanofi Sa
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Publication date
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Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX340370B publication Critical patent/MX340370B/es

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Abstract

La presente invención se refiere a compuestos de fórmula I, (ver fórmula) en la que A, D, E, L, G, R10, R30, R40, R50 y R60 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Son inhibidores de la proteasa catepsina A, y son útiles, por ejemplo, para el tratamiento de enfermedades tales como aterosclerosis, insuficiencia cardiaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
MX2014010972A 2011-01-26 2012-01-26 Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. MX340370B (es)

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DK2667870T3 (en) 2016-12-12
PT2667870T (pt) 2016-11-16
IL249826A0 (en) 2017-02-28
AR085013A1 (es) 2013-08-07
HK1187253A1 (zh) 2014-04-04
HUE029781T2 (en) 2017-04-28
IL227025A (en) 2017-05-29
RU2632897C2 (ru) 2017-10-11
AU2012210513A1 (en) 2013-08-15
MX347157B (es) 2017-04-18
BR112013016508A2 (pt) 2016-09-27
CN103442712A (zh) 2013-12-11
EP2667870A1 (en) 2013-12-04
US20120252809A1 (en) 2012-10-04
PL2667870T3 (pl) 2017-02-28
NZ613672A (en) 2015-04-24
LT2667870T (lt) 2016-12-12
CA2822120A1 (en) 2012-08-02
CN103442712B (zh) 2016-01-20
WO2012101197A1 (en) 2012-08-02
UY33874A (es) 2012-08-31
ES2604556T3 (es) 2017-03-07
HRP20161545T1 (hr) 2016-12-30
IL249825A0 (en) 2017-02-28
US8669370B2 (en) 2014-03-11
SI2667870T1 (sl) 2016-12-30
AU2012210513B2 (en) 2016-09-22
US9029559B2 (en) 2015-05-12
US20140194445A1 (en) 2014-07-10
US9120783B2 (en) 2015-09-01
US20140135328A1 (en) 2014-05-15
EP2667870B1 (en) 2016-08-24
SG191826A1 (en) 2013-08-30
JP5957467B2 (ja) 2016-07-27
MA34917B1 (fr) 2014-02-01
RU2013139349A (ru) 2015-03-10
CO6761373A2 (es) 2013-09-30
MX2013007608A (es) 2013-09-06
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